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Lipin 1 Proteins (LPIN1)

LPIN1 encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Additionally we are shipping Lipin 1 Antibodies (129) and Lipin 1 Kits (10) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LPIN1 23175 Q14693
LPIN1 14245 Q91ZP3
Rat LPIN1 LPIN1 313977  
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Top Lipin 1 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

LPIN1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Lipin 1 (LPIN1) Interaction Partners

Human Lipin 1 (LPIN1) interaction partners

  1. lipin-1 has a critical role in the regulation of macrophage inflammatory responses to modified-LDL

  2. Results of our study suggest that rs2716610: C>T polymorphism of LPIN1 gene could have a protective effect against development of metabolic syndrome, while rs11693809: C>T might affect a glucose control in patients with MS.

  3. Lipin-1 controls main cellular processes involved in cancer progression and that its targeting, alone or in combination with other treatments, could open new avenues in anticancer therapy.

  4. Lipin1beta might play a role in the pathogenesis of insulin (show INS Proteins) resistance in gestational diabetes mellitus

  5. LPIN1 plays a functional role in lipid synthesis and storage, a role which is highly conserved from human to yeast.

  6. the lipin-1 N-terminal domain is important for its catalytic activity, nuclear localization, and binding to PP-1cgamma

  7. Lipin-1 deficiency is associated with lipid metabolism alterations resulting in massive rhabdomyolysis.

  8. the SNP in the LPIN1 gene (rs10192566) had no effect on the trough rosiglitazone steady-state concentration.

  9. Phosphorylation of lipin 1 and charge on the phosphatidic acid head group control its phosphatidic acid phosphatase activity and membrane association

  10. Data suggests common single nucleotide polymorphisms within the LPIN1 region were associated with Type 2 diabetes and metabolic traits in the Chinese population.

Mouse (Murine) Lipin 1 (LPIN1) interaction partners

  1. lipin-1 has a critical role in the regulation of macrophage inflammatory responses to modified-LDL

  2. c-fos has a role in increasing the catalytic efficiency of lipin 1 beta

  3. reveals a previously unknown role of lipin1 in skeletal muscle regeneration and expands our understanding of the cellular and molecular mechanisms underlying skeletal muscle regeneration

  4. deficits in hepatic PAP (show ASAP1 Proteins) activity do not impair TG synthesis and accumulation

  5. lipin-1 PAP (show ASAP1 Proteins) activity functions in autophagy to activate the PKD (show PRKD1 Proteins)-Vps34 (show PIK3C3 Proteins) cascade to promote autolysosome maturation.

  6. The findings demonstrate an unanticipated role for lipin-1 as a mediator of macrophage proinflammatory activation and support a critical link between lipid biosynthesis and systemic inflammatory responses.

  7. in addition to their roles during early adipogenesis, lipin1 and lipin2 (show LPIN2 Proteins) also have a role in lipid droplet biogenesis.

  8. hepatic removal of lipin-1 in mice augmented ethanol-induced impairment of hepatic fatty acid oxidation and lipoprotein production, likely by way of deactivation of peroxisome proliferator-activated receptor gamma coactivator-1 alpha.

  9. lipin1 functions as a key regulator of PPARgamma (show PPARG Proteins) activity through its ability to release co-repressors and recruit co-activators via a mechanism other than PPARalpha (show PPARA Proteins) activation

  10. These results suggested that ER stress might be involved inthe pathogenesis of obesity through lipin-1 depletion.

Pig (Porcine) Lipin 1 (LPIN1) interaction partners

  1. The lipin1 gene may have a crucial effect on body lipid accumulation in pigs.

  2. Different genotypes of the Lpin1 gene were associated with percentage of leaf fat and intramuscular fat.

Cow (Bovine) Lipin 1 (LPIN1) interaction partners

  1. The results of this study suggest that suggest that SLC27A6, ACSL1 (show Acsl1 Proteins), FABP3 (show FABP3 Proteins), AGPAT6 (show AGPAT6 Proteins), and LPIN1 coordinately regulate the channeling of fatty acids toward copious milk fat synthesis in bovine mammary.

Lipin 1 (LPIN1) Protein Profile

Protein Summary

This gene encodes a magnesium-ion-dependent phosphatidic acid phosphohydrolase enzyme that catalyzes the penultimate step in triglyceride synthesis including the dephosphorylation of phosphatidic acid to yield diacylglycerol. Expression of this gene is required for adipocyte differentiation and it also functions as a nuclear transcriptional coactivator with some peroxisome proliferator-activated receptors to modulate expression of other genes involved in lipid metabolism. Mutations in this gene are associated with metabolic syndrome, type 2 diabetes, and autosomal recessive acute recurrent myoglobinuria (ARARM). This gene is also a candidate for several human lipodystrophy syndromes. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their full-length structures have not been determined.

Gene names and symbols associated with Lipin 1 Proteins (LPIN1)

  • lipin 1 (LPIN1)
  • lipin 1 (lpin1)
  • lipin 1 (Lpin1)
  • 4631420P06 protein
  • fld protein
  • Kiaa0188 protein
  • lipin1 protein
  • LPIN1 protein
  • mKIAA0188 protein
  • PAP1 protein
  • zgc:194552 protein
  • zgc:194558 protein

Protein level used designations for Lipin 1 Proteins (LPIN1)

lipin 1 , phosphatidate phosphatase LPIN1-like , lipin-1 , phosphatidate phosphatase LPIN1 , fatty liver dystrophy protein

GENE ID SPECIES
459036 Pan troglodytes
779950 Xenopus (Silurana) tropicalis
100231657 Taeniopygia guttata
100400101 Callithrix jacchus
100458857 Pongo abelii
100465923 Ailuropoda melanoleuca
100539289 Meleagris gallopavo
100586976 Nomascus leucogenys
23175 Homo sapiens
475670 Canis lupus familiaris
14245 Mus musculus
313977 Rattus norvegicus
799099 Danio rerio
421945 Gallus gallus
100170845 Sus scrofa
537224 Bos taurus
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