anti-Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) Antibodies

The protein encoded by LDLRAP1 is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. Additionally we are shipping LDLRAP1 Proteins (8) and LDLRAP1 Kits (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LDLRAP1 26119 Q5SW96
LDLRAP1 100017 Q8C142
LDLRAP1 500564  
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Top anti-LDLRAP1 Antibodies at antibodies-online.com

Showing 10 out of 129 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-LDLRAP1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated ELISA, WB ABIN185037 staining (3µg/ml) of Human Liver lysate (RIPA buffer, 30µg total protein per lane). Primary incubated for 1 hour. Detected by western blot using chemiluminescence. 100 μg Log in to see 6 to 7 Days
$326.89
Details
Cow Rabbit Un-conjugated WB Host: Rabbit Target Name: Ldlrap1 Sample Type: Mouse Testis lysates Antibody Dilution: 1.0ug/ml 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA, IHC (p) 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Goat Un-conjugated ELISA, WB 100 μg Log in to see 7 to 9 Days
$610.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of LDLRAP1 Antibody (N-term) (ABIN392553) in K562 cell line lysates (35 µg/lane). LDLRAP1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human colon carcinoma tissue reacted with LDLRAP1 antibody (N-term) (ABIN392553), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Goat Un-conjugated WB   0.1 mg Log in to see 12 to 15 Days
$375.38
Details
Human Rabbit Un-conjugated WB LDLRAP1 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 2 to 3 Days
$473.93
Details
Dog Mouse Un-conjugated WB 100 μL Log in to see 7 to 9 Days
$493.17
Details

LDLRAP1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Mouse (Murine) ,
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Rat (Rattus) ,
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Top referenced anti-LDLRAP1 Antibodies

  1. Human Polyclonal LDLRAP1 Primary Antibody for ELISA, WB - ABIN249957 : He, Gupta, Yi, Michaely, Hobbs, Cohen: ARH is a modular adaptor protein that interacts with the LDL receptor, clathrin, and AP-2. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal LDLRAP1 Primary Antibody for IF, IHC (p) - ABIN565226 : Quagliarini, Vallvé, Campagna, Alvaro, Fuentes-Jimenez, Sirinian, Meloni, Masana, Arca: Autosomal recessive hypercholesterolemia in Spanish kindred due to a large deletion in the ARH gene. in Molecular genetics and metabolism 2007 (PubMed)
    Show all 2 Pubmed References

  3. Human Polyclonal LDLRAP1 Primary Antibody for WB - ABIN631410 : Holla, Strøm, Cameron, Berge, Leren: A chimeric LDL receptor containing the cytoplasmic domain of the transferrin receptor is degraded by PCSK9. in Molecular genetics and metabolism 2010 (PubMed)

More Antibodies against LDLRAP1 Interaction Partners

Human Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) interaction partners

  1. LDLRAP1 associated with Familial Hypercholesterolemia and Polygenic Hypercholesterolemia in patients with Acute Coronary Syndrome , age /=160 mg/dl.

  2. Numb (show NUMB Antibodies) specifically regulates NPC1L1 (show NPC1L1 Antibodies)-mediated cholesterol absorption both in human intestine and liver, distinct from ARH and Dab2 (show DAB2 Antibodies), which selectively participate in LDLR (show LDLR Antibodies)-mediated LDL uptake.

  3. Identification of ARH gene and characterization of its mutations in Autosomal Recessive Hypercholesterolemia patients [Review]

  4. cells that depend upon ARH for LDL uptake can control which lipoproteins are internalized by their LDLRs through changes in nitric oxide.

  5. This work identified a combined LDL receptor (show LDLR Antibodies) and LDLRAP1 mutation as the cause for severe familial hypercholesterolemia in a family of Turkish descent.

  6. The report provides evidence that endocytosis of the ROMK potassium channel is controlled by LDLRAP1 (ARH). ROMK binds directly to the LDLRAP1, and this interaction is mediated by a novel variant of the canonical "NPXY" endocytotic signal, YxNPxFV. LDLRAP1-knockout mice are unable to physiologically regulate ROMK.

  7. report the crystal structure at 1.37-A resolution of the phosphotyrosine-binding (PTB (show PTBP1 Antibodies)) domain of ARH in complex with an LDLR (show LDLR Antibodies) tail peptide containing the FxNPxY(0) internalization signal

  8. LDL receptor (show LDLR Antibodies)/LDLRAP1 double heterozygous mutations may account for severer phenotype in terms of xanthoma and atherosclerotic cardiovascular disease in familial hypercholesterolemia patients.

  9. ARH protein is involved in cell cycle progression, possibly by affecting nuclear membrane formation through interaction with lamin B1 (show LMNB1 Antibodies) or other mitotic proteins, and its absence affects cell proliferation and induces premature senescence.

  10. Knockdown of ARH in polarized epithelial cells leads to specific apical missorting of truncated LDLR (show LDLR Antibodies), which encodes only the FxNPxY motif (LDLR (show LDLR Antibodies)-CT27 (show CTCFL Antibodies)).

Mouse (Murine) Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) interaction partners

  1. The combination of Arh and Dab2 (show DAB2 Antibodies) is responsible for the majority of adaptor function in LDLR (show LDLR Antibodies) endocytosis and LDLR (show LDLR Antibodies)-mediated cholesterol homeostasis.

  2. cells that depend upon ARH for LDL uptake can control which lipoproteins are internalized by their LDLRs through changes in nitric oxide.

  3. results are consistent with LDL receptor adaptor protein(ARH) playing a critical and specific role in low density lipoprotein receptor (show LDLR Antibodies) endocytosis in the liver

  4. Hepatocytes do not take-up LDL in vivo without ARH protein, but they normally catabolize LDL in vitro. Thus, the requirement of ARH protein for proper functioning of the LDLR (show LDLR Antibodies) is not cell-specific, but rather may depend on the cellular environment.

  5. the LDL receptor (show LDLR Antibodies) alone can account for the clearance of apoE (show APOE Antibodies)-containing lipoproteins in mice, and the contribution of other receptors is minimal, and b) defects in either increase the sensitivity to apoE (show APOE Antibodies)-induced hypertriglyceridemia in mice.

  6. Taken together, our data suggest that ARH is a multifunctional protein whose spectrum of function in the brain goes beyond the traditionally known metabolism of lipoproteins, and that ARH may be locally synthesized in the axon.

  7. the endocytic adaptor protein ARH associates with motor and centrosomal proteins and is involved in centrosome assembly and cytokinesis

  8. Loss of gamma-secretase function decreased endocytosis of low-density lipoprotein (LDL) receptor (show LDLR Antibodies)

  9. ARH marks ROMK for clathrin-dependent endocytosis, in concert with the demands of potassium homeostasis

LDLRAP1 Antigen Profile

Protein Summary

The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.

Gene names and symbols associated with LDLRAP1

  • low density lipoprotein receptor adaptor protein 1 (ldlrap1) antibody
  • low density lipoprotein receptor adaptor protein 1 (LDLRAP1) antibody
  • low density lipoprotein receptor adaptor protein 1 (LOC100342213) antibody
  • low density lipoprotein receptor adaptor protein 1 (Ldlrap1) antibody
  • low density lipoprotein receptor adaptor protein 1 (ldlrap1-b) antibody
  • low density lipoprotein receptor adaptor protein 1 (ldlrap1-a) antibody
  • low density lipoprotein receptor adaptor protein 1a (ldlrap1a) antibody
  • AA691260 antibody
  • Arh antibody
  • Arh1 antibody
  • ARH2 antibody
  • FHCB1 antibody
  • FHCB2 antibody
  • ldlrap1 antibody
  • RGD1563417 antibody
  • sb:cb50 antibody
  • xptb antibody
  • zgc:56121 antibody

Protein level used designations for LDLRAP1

low density lipoprotein receptor adaptor protein 1 , low-density lipoprotein adaptor protein , low density lipoprotein receptor adapter protein 1 , LDL receptor adaptor protein , autosomal recessive hypercholesterolemia protein , autosomal recessive hypercholesterolemia protein homolog , ARH beta , autosomal recessive hypercholesterolemia protein homolog beta , low density lipoprotein receptor adapter protein 1-B , xARH beta , ARH alpha , autosomal recessive hypercholesterolemia protein homolog alpha , low density lipoprotein receptor adapter protein 1-A , phosphotyrosine binding protein , phosphotyrosine-binding protein , xARH alpha , xcat4

GENE ID SPECIES
549868 Xenopus (Silurana) tropicalis
739347 Pan troglodytes
100125967 Sus scrofa
100342213 Oryctolagus cuniculus
511199 Bos taurus
26119 Homo sapiens
612219 Canis lupus familiaris
100017 Mus musculus
500564 Rattus norvegicus
414519 Xenopus laevis
419589 Gallus gallus
398568 Xenopus laevis
368278 Danio rerio
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