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Lumican Proteins (LUM)

LUM encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. Additionally we are shipping Lumican Antibodies (68) and Lumican Kits (33) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
LUM 4060 P51884
LUM 17022 P51885
LUM 81682 P51886
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Top Lumican Proteins at antibodies-online.com

Showing 10 out of 18 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_HEK-293 Cells Human His tag 100 μg Log in to see 16 to 41 Days
$286.00
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$728.20
Details
HOST_HEK-293 Human His tag   0.1 mg Log in to see 2 to 3 Days
$515.63
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$528.00
Details
Yeast Rabbit His tag   1 mg Log in to see 56 to 66 Days
$2,460.33
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,858.17
Details

LUM Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Lumican Proteins

  1. Human LUM Protein expressed in Human Cells - ABIN2004465 : Chakravarti, Stallings, SundarRaj, Cornuet, Hassell: Primary structure of human lumican (keratan sulfate proteoglycan) and localization of the gene (LUM) to chromosome 12q21.3-q22. in Genomics 1995 (PubMed)
    Show all 4 references for ABIN2004465

  2. Human LUM Protein expressed in HEK-293 Cells - ABIN2181488 : Onnerfjord, Heathfield, Heinegård: Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry. in The Journal of biological chemistry 2003 (PubMed)
    Show all 2 references for ABIN2181488

  3. Human LUM Protein expressed in Wheat germ - ABIN1309888 : Littlechild, Zhang, Tomich, Conrad: Fibrinogen, riboflavin, and UVA to immobilize a corneal flap--molecular mechanisms. in Investigative ophthalmology & visual science 2012 (PubMed)
    Show all 2 references for ABIN1309888

More Proteins for Lumican (LUM) Interaction Partners

Horse (Equine) Lumican (LUM) interaction partners

  1. temporal expression of LUM mRNA during dermal wound repair in the horse

Zebrafish Lumican (LUM) interaction partners

  1. the role of lumican in the development of axial myopia

Human Lumican (LUM) interaction partners

  1. fibroblasts stimulated with the fibrocyte-secreted inflammatory signal tumor necrosis factor-alpha (show TNF Proteins) secrete the small leucine-rich proteoglycan (show Vcan Proteins) lumican.

  2. This meta-analysis suggests that LUM polymorphisms are associated with the risk of high myopia.

  3. The results suggest that regions within LUM is associated with ACL (show ACLY Proteins) injury susceptibility and that genetic sequence variability within genes encoding proteoglycans may potentially modulate the ligament fibril properties.

  4. meta-analysis, including 1,545 subjects from 5 studies, indicated that Chinese lumican rs3759223 C allele carriers had a decreased risk of high myopia in comparison to T allele carriers

  5. These findings suggest that lumican is a potent differential diagnostic marker that distinguishes hidroacanthoma simplex from clonal-type seborrheic keratosis.

  6. Lumican, decorin (show DCN Proteins) and dermatopontin (show DPT Proteins) are differentially expressed and may serve as biomarkers for metastatic and recurrent Giant cell tumor of bone

  7. Lumican binds ALK5 (show TGFBR1 Proteins) to promote epithelium wound healing

  8. Lack of Lumican expression is associated with recurrence in colon cancer.

  9. These findings suggest that lumican plays an important role in the pathogenesis of Bowen disease and actinic keratosis

  10. lumican may be involved in cell growth and invasion through the regulation of 24 proteins expressed in pancreatic ductal adenocarcinoma.

Mouse (Murine) Lumican (LUM) interaction partners

  1. LUM may coordinate multiple factors of collagen assembly in the murine heart.

  2. Lumican and biglycan (show BGN Proteins) influence corneal keratocyte lamellipodia organization and are critical in the regulation of stromal collagen fibrillogenesis.

  3. Alterations in glycosylated lumican core protein might be implicated in myocardial remodeling and reverse remodeling, with a potential important role for CS/DS GAG chain-synthesizing enzymes.

  4. pro-inflammatory cytokine TNF-alpha (show TNF Proteins) was comparably low 24 hours after infection, but significantly higher in the Lum(-/-) compared to Lum(+/-) infected corneas by 2-5 days after infection

  5. lumican present in the reactive stroma surrounding prostate primary tumors plays a restrictive role on cancer progression

  6. To investigate the functional role of lumican in hepatic fibrosis, lumican null (Null) and wild-type (WT) littermates were administered carbon tetrachloride intra-peritoneally. Hepatic fibrosis was greatly reduced in null animals.

  7. lumican has a major protective role in gram-negative bacterial infections, a novel function for small leucine-rich repeat proteoglycans.

  8. deficiency combined with fibromodulin (show FMOD Proteins) deficiency manifest several clinical features or Ehlers-Danlos syndrome

  9. The results indicate that the cysteine-rich domain of lumican is important in collagen fibrillogenesis and stromal matrix assembly

  10. lumican has a novel regulatory role in keratocan (show KERA Proteins) expression at the transcriptional level

Cow (Bovine) Lumican (LUM) interaction partners

  1. These results suggest that lumican plays a pivotal role in the development of tissue engineered cartilage and that regulation of this protein may be important for the production of high-quality implants.

Rabbit Lumican (LUM) interaction partners

  1. FGF-2 (show FGF2 Proteins)- and TGF-beta1 (show TGFB1 Proteins)-activation of JNK (show MAPK8 Proteins) signaling pathway may be partly responsible for the downregulation of keratocan (show KERA Proteins) and lumican expression in activated corneal keratocytes observed during corneal stromal wound healing.

Lumican (LUM) Protein Profile

Protein Summary

This gene encodes a member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin. In these bifunctional molecules, the protein moiety binds collagen fibrils and the highly charged hydrophilic glycosaminoglycans regulate interfibrillar spacings. Lumican is the major keratan sulfate proteoglycan of the cornea but is also distributed in interstitial collagenous matrices throughout the body. Lumican may regulate collagen fibril organization and circumferential growth, corneal transparency, and epithelial cell migration and tissue repair.

Gene names and symbols associated with Lumican Proteins (LUM)

  • lumican (LUM)
  • lumican (lum)
  • lumican (CpipJ_CPIJ010209)
  • lumican (Lum)
  • DKFZp468L1116 protein
  • Ldc protein
  • MGC64527 protein
  • SLRR2D protein
  • zgc:86661 protein

Protein level used designations for Lumican Proteins (LUM)

lumican , zlum , Keratan sulfate proteoglycan lumican , KSPG lumican , keratan sulfate proteoglycan lumican , lumican proteoglycan , KSPG , corneal keratan sulfate proteoglycan 37B core protein , keratan sulfate proteoglycan

GENE ID SPECIES
100009681 Equus caballus
379493 Xenopus laevis
415149 Danio rerio
452119 Pan troglodytes
482599 Canis lupus familiaris
496415 Xenopus (Silurana) tropicalis
709830 Macaca mulatta
6043170 Culex quinquefasciatus
100126729 Papio anubis
100171487 Pongo abelii
100195033 Salmo salar
100595797 Nomascus leucogenys
4060 Homo sapiens
17022 Mus musculus
81682 Rattus norvegicus
100152607 Sus scrofa
280847 Bos taurus
417891 Gallus gallus
100008665 Oryctolagus cuniculus
100732503 Cavia porcellus
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