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MDS1 and EVI1 Complex Locus Proteins (MECOM)

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. Additionally we are shipping MDS1 and EVI1 Complex Locus Antibodies (117) and MDS1 and EVI1 Complex Locus Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MECOM 2122 Q03112,Q13465
MECOM 14013 Q9Z1L8
Rat MECOM MECOM 294924  
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Top MDS1 and EVI1 Complex Locus Proteins at antibodies-online.com

Showing 4 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 49 to 54 Days
$13,567.94
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   20 μg Log in to see 3 to 4 Days
$388.93
Details

MECOM Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,
Mouse (Murine)

More Proteins for MDS1 and EVI1 Complex Locus (MECOM) Interaction Partners

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (show NOTCH1 Proteins) signaling

  2. Prdm3 and prdm16 (show PRDM16 Proteins) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. MECOM deletion is associated with congenital thrombocytopenia.

  2. ETV6 (show ETV6 Proteins)/RUNX1 (show RUNX1 Proteins) transcript is a target of RNA-binding protein (show PTBP1 Proteins) IGF2BP1 (show IGF2BP1 Proteins) in t(12;21)(p13;q22)-positive acute lymphoblastic leukemia.

  3. Runx1 (show RUNX1 Proteins) haploinsufficiency appears to predispose FPD patients to MM by expanding the pool of stem/progenitor cells and blocking myeloid differentiation in response to G-CSF (show CSF3 Proteins).

  4. RUNX1 haploinsufficiency collaborates with genetic alterations conferring clonal advantage such as TET2 mutation or trisomy 21 to establish pre-leukemic state.

  5. involvement of MECOM in patients with acute myeloid leukemia (show BCL11A Proteins) and myelodysplastic syndrome with various 3q abnormalities

  6. The study shows a low representation of ETV6 (show ETV6 Proteins)-RUNX1 (show RUNX1 Proteins) fusion oncogenes among pediatric acute lymphoblastic leukemia patients from King Abdulaziz Medical City, National Guard Health Affairs, Riyadh, Saudi Arabia.

  7. Germline RUNX1 (show RUNX1 Proteins) mutations are associated with leukemic progression of familial platelet disorder with predisposition to acute myeloid leukemia (show BCL11A Proteins).

  8. Two novel translocations leading to the inactivation of RUNX1 (show RUNX1 Proteins) and its partners SIN3A (show SIN3A Proteins) and TCF12 (show TCF12 Proteins) in myeloid leukemia (show BCL11A Proteins).

  9. RUNX1-Evi-1 (show RUNX1 Proteins) may promote proliferation and apoptosis resistance of primitive hematopoietic cell, and inhibit the differentiation of myeloid cells with the synergy of different pathways and factors.

  10. Thus, an NGF (show NGFB Proteins)/TrkA (show NTRK1 Proteins)-MAPK (show MAPK1 Proteins)-CBFbeta (show CBFB Proteins) pathway converges with Islet1 (show ISL1 Proteins)-Runx1 (show RUNX1 Proteins) signaling to promote Runx1 (show RUNX1 Proteins)/CBFbeta (show CBFB Proteins) holocomplex formation and nonpeptidergic nociceptor maturation.

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) interaction partners

  1. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (show CSF2 Proteins), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (show CSF2 Proteins) levels.

  2. Survivin (show BIRC5 Proteins) partially regulates HSC (show FUT1 Proteins) function by modulating the Evi-1 transcription factor and its downstream targets

  3. Thrombopoietin (show THPO Proteins)/MPL (show MPL Proteins) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  4. Prdm16 (show PRDM16 Proteins) and Prdm3 control postnatal BAT (show BAAT Proteins) identity and function.

  5. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  6. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (show MLL Proteins)) fusion protein (MFP) leukemia

  7. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (show CEBPB Proteins), liver inhibitory protein (LIP), induced acute myeloid leukemia (show BCL11A Proteins) with short latencies in a mouse bone marow transplantation model.

  8. Transient Evi1 transfection inhibited TGF-beta (show TGFB1 Proteins)-induced transcriptional activity and reversed the growth inhibitory effect of TGF-beta (show TGFB1 Proteins) in MC-26 (show Glycam1 Proteins) mouse colon cancer cells.

  9. Evi1 is a key regulator of adipogenic competency

  10. Data identify Prdm3 and Prdm16 (show PRDM16 Proteins) as H3K9me1 methyltransferases and expose a functional framework in which anchoring to the nuclear periphery helps maintain the integrity of mammalian heterochromatin.

MDS1 and EVI1 Complex Locus (MECOM) Protein Profile

Protein Summary

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with MECOM

  • MDS1 and EVI1 complex locus (mecom)
  • MDS1 and EVI1 complex locus (MECOM)
  • MDS1 and EVI1 complex locus (LOC100343228)
  • MDS1 and EVI1 complex locus (Mecom)
  • runt-related transcription factor 1 (RUNX1)
  • AML1 protein
  • AML1-EVI-1 protein
  • AMLCR1 protein
  • CBFA2 protein
  • D630039M04Rik protein
  • EVI-1 protein
  • Evi1 protein
  • im:7140716 protein
  • Jbo protein
  • Mds protein
  • Mds1 protein
  • Mds1-Evi1 protein
  • PEBP2aB protein
  • Prdm3 protein
  • Znfpr1b1 protein

Protein level used designations for MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

GENE ID SPECIES
497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
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