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MICB encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Additionally we are shipping MICB Antibodies (65) and MICB Kits (10) and many more products for this protein.
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Human MICB Protein expressed in Human Cells - ABIN2003355
Bauer, Groh, Wu, Steinle, Phillips, Lanier, Spies: Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. in Science (New York, N.Y.) 1999
Show all 3 references for ABIN2003355
Findings shown here are important from an anthropologic perspective and will inform future studies of the potential role of MICA (show MICA Proteins) and MICB genes in allogeneic organ transplantation and HLA-linked disease association in populations of related ancestry.
IMP3 (show IGF2BP3 Proteins) directly interacts with ULBP2 (show ULBP2 Proteins) mRNA, leading to ULBP2 (show ULBP2 Proteins) transcript destabilization and reduced ULBP2 (show ULBP2 Proteins) surface expression and indirectly downregulates MICB with a mechanism functionally distinct from that of ULBP2 (show ULBP2 Proteins).
Reversal of epigenetic silencing of MICA (show MICA Proteins) and MICB improves immune recognition and killing of Merkel cell carcinoma cells.
We have now found a total of 15 individual MICB promoter sequences, varying by combination of 18 polymorphic positions within the MICB minimal promoter sequence.
Our results suggest that locally sustained expression of MICA (show MICA Proteins) and MICB in the tumor may contribute to the malignant progression of Gastric cancer(GC) and that expression of these ligands predicts an unfavorable prognosis in GC patients presenting large tumors.
Estrogen upregulates MICA (show MICA Proteins)/B expression in human non-small cell lung cancer through the regulation of ADAM17 (show ADAM17 Proteins).
Aligned with MICB*005:02, MICB*030 has a nonsynonymous adenine substitution at nucleotide position 50 in exon 3, leading to amino acid change from serine to arginine at codon 102 of the mature MICB molecule.
This study suggests that NKG2D (show KLRK1 Proteins) ligands shedding of MICA (show MICA Proteins), MICB and ULBP-2 (show ULBP2 Proteins) is a novel pathway in endometriosis complex pathogenesis that impairs Natural Killer Cells cell function.
six RNA-binding proteins that bind and regulate the expression of MICB.
The sMICB serum levels were significantly increased in hepatitis B patients compared to healthy controls. The sMICB serum levels were decreased in a treated hepatocellular carcinoma (HCC (show FAM126A Proteins)) patient group compared to a not-treated HCC (show FAM126A Proteins) patient group.
This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules\; however, it does not associate with beta-2-microglobulin or bind peptides.
MHC class I chain-related protein B
, MHC class I mic-B antigen
, MHC class I-like molecule PERB11.2-IMX
, stress inducible class I homolog