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Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Additionally we are shipping MYST Histone Acetyltransferase 2 Proteins (12) and MYST Histone Acetyltransferase 2 Kits (3) and many more products for this protein.
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Human Polyclonal MYST2 Primary Antibody for WB - ABIN1882086
Wu, Liu: Role for Plk1 phosphorylation of Hbo1 in regulation of replication licensing. in Proceedings of the National Academy of Sciences of the United States of America 2008
Show all 2 references for ABIN1882086
Human Polyclonal MYST2 Primary Antibody for EIA, IHC (p) - ABIN4620487
Iizuka, Sarmento, Sekiya, Scrable, Allis, Smith: Hbo1 Links p53-dependent stress signaling to DNA replication licensing. in Molecular and cellular biology 2007
Show all 2 references for ABIN4620487
Human Polyclonal MYST2 Primary Antibody for IF, ELISA - ABIN1533558
Olsen, Blagoev, Gnad, Macek, Kumar, Mortensen, Mann: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. in Cell 2006
the possible binding sites and biological functions of HBO1, were identified.
Data show that HTLV-1 basic leucine zipper (bZIP) factor (HBZ (show HBZ Antibodies)) represses p53 (show TP53 Antibodies) activity by direct inhibition of the histone acetyltransferase (HAT (show HAT Antibodies)) activity of p300/CBP (show CREBBP Antibodies) and the HAT (show MGEA5 Antibodies) activity of HBO1: [HBZ (show HBZ Antibodies)]
This study demonstrates that CRL4(DDB2 (show DDB2 Antibodies)) is a novel ubiquitin ligase of HBO1.
Taken together, MYST2 is a repressed growth suppressor in AML (show RUNX1 Antibodies) mediating reduced acetylation of histone 4 at residue 5 and is associated with inferior AML patient survival.
Myst2-mediated histone acetylation may be required for recruitment of Oct4 to the Nanog promoter
Increase in the number of cells with cytoplasmic JADE1S correlated with activation of tubular cell proliferation and inversely correlated with the number of cells with nuclear JADE1S, supporting role of HBO1-JADE1 (show PHF17 Antibodies) shuttling during organ regeneration.
Hbo1 modulated transcription by estrogen receptor-alpha (show ESR1 Antibodies). Hbo1 contributes to degradation of ER-alpha (show ESR1 Antibodies) by ubiquitination through lysine 48.
HBO1, but not SRC-2 (show NCOA2 Antibodies), expression was reduced in testes of patients with androgen insensitivity syndromes compared to normal testes.
Phosphorylated Hbo1 expression is associated with breast cancer.
alternate choice of subunits associated with HBO1 can switch its specificity between H4 and H3 tails
MYST2 gene was cloned; results demonstrated that 2872G > A substitution was significantly associated with the litter size of all parities in Large White sows and Landrace sows
These results indicate that BRPF3 (show BRPF3 Antibodies) forms a functional tetrameric complex with HBO1 but is not required for mouse development and survival
Taken together, MYST2 is a repressed growth suppressor in AML (show RUNX1 Antibodies) mediating reduced acetylation of histone 4 at residue 5
Brd1 (show BRD1 Antibodies)-mediated Hbo1 activity is crucial for efficient activation of CD8 (show CD8A Antibodies) expression via acetylation at H3K14, which serves as an epigenetic mark that promotes the recruitment of transcription machinery to the CD8 (show CD8A Antibodies) enhancers.
Modulation of Fbxw15 levels was able to differentially regulate histone H3K14 acetylation and cellular proliferation by altering HBO1 levels.
The Hbo1-Brd1 (show BRD1 Antibodies) complex is the major H3K14 HAT (show HAT Antibodies) required for transcriptional activation of erythroid developmental regulator (show GIPC1 Antibodies) genes.
the primary role of HBO1 in development is that of a transcriptional activator, which is indispensable for H3K14 acetylation and for the normal expression of essential genes regulating embryonic development
reveal a direct regulatory connection between p53 (show TP53 Antibodies)-responsive stress signaling and Hbo1-dependent chromatin pathways
FAD24 (show NOC3L Antibodies) controls DNA replication by recruiting HBO1 to origins of DNA replication and is required for MCE during adipocyte differentiation.
Component of the HBO1 complex which has a histone H4- specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may regulate DNA replication and act as a coactivator of TP53-dependent transcription. Specifically represses AR-mediated transcription (By similarity).
MOZ, YBF2/SAS3, SAS2 and TIP60 protein 2
, MYST histone acetyltransferase 2
, MYST protein 2
, histone acetyltransferase KAT7
, histone acetyltransferase MYST2
, histone acetyltransferase binding to ORC1
, lysine acetyltransferase 7