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MSR1 encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of MSR1. Additionally we are shipping Macrophage Scavenger Receptor 1 Antibodies (234) and Macrophage Scavenger Receptor 1 Kits (22) and many more products for this protein.
Showing 10 out of 16 products:
SR-A1 suppresses lung cancer metastasis by downregulating SAA1 (show SAA1 Proteins) production in tumor-associated macrophages (TAM (show CCNA1 Proteins)).
PTX2 (show APCS Proteins) was identified PTX2 (show APCS Proteins) as a novel partner for FX, and both proteins cooperated to prevent their SR-AI-mediated uptake by macrophages.
we found that higher percentages of circulating CD14 (show NDUFA2 Proteins)+CD204+, CD14 (show NDUFA2 Proteins)+CD163 (show CD163 Proteins)+CD204+ M2-like monocytes were significantly associated with TNM (show ODZ1 Proteins) stage, lymph node metastasis, and histological differentiation.
Identifying N-linked glycan moiety and motifs in the cysteine-rich domain critical for N-glycosylation and intracellular trafficking of SR-AI and MARCO (show MARCO Proteins).
The P275A Polymorphism in the Macrophage Scavenger Receptor 1 Gene is not associated with Prostate Cancer Risk.
Cyr61 (show CYR61 Proteins) promotes CD204 expression and the migration of macrophages via MEK (show MAP2K1 Proteins)/ERK (show EPHB2 Proteins) pathway in esophageal squamous cell carcinoma
miR (show MLXIP Proteins)-29a promotes scavenger receptor A expression by targeting QKI (show QKI Proteins) during monocyte-macrophage differentiation.
Heptapeptide XD4 activates the class A scavenger receptor (SR-A) on the glia by increasing the binding of Abeta (show APP Proteins) to SR-A, thereby promoting glial phagocytosis of Abeta (show APP Proteins) oligomer in microglia.
The truncating variant Arg293X in the gene encoding SRA (show SRA1 Proteins)-I/II was associated with reduced lung function and with increased risk of COPD (show ARCN1 Proteins) among men, as well as among alpha1-antitrypsin MZ and superoxide dismutase (show SOD1 Proteins)-3 E1I1 heterozygotes.
monomeric collagen type I via CD204 induces phospho-Akt (show AKT1 Proteins) expression shifting alveolar macrophages to the profibrotic M2 type. Innate immune responses induced by collagen monomers might perpetuate pulmonary fibrosis.
Data (including data from studies conducted in cells from knockout mice) suggest that signaling via Lpar1 (show LPAR1 Proteins), Cd14 (show CD14 Proteins), and Scara1 mediates uptake of oxidized LDL by macrophages leading to foam cell formation; lysophosphatidic acid (LPA) induces expression of Cd14 (show CD14 Proteins) and Scara1 in macrophages. (Lpar1 (show LPAR1 Proteins) = LPA receptor 1 (show LPAR1 Proteins); Cd14 (show CD14 Proteins) = monocyte differentiation antigen CD14 (show CD14 Proteins); Scara1 = scavenger receptor class A type I)
Common damage-associated molecular patterns (DAMPs) were internalized through the class A scavenger receptors MSR1 and MARCO (show MARCO Proteins) in vitro. In ischemic murine brain, DAMP (show AMPH Proteins) internalization was largely mediated by MSR1. Combined deficiency for Msr1 and Marco (show MARCO Proteins) in infiltrating myeloid cells caused impaired clearance of DAMPs, more severe inflammation, and exacerbated neuronal injury in a murine model of ischemic stroke.
PTX2 (show PITX2 Proteins) was identified PTX2 (show PITX2 Proteins) as a novel partner for FX, and both proteins cooperated to prevent their SR-AI-mediated uptake by macrophages.
this study shows that Msr1 functions as co-receptor along with TLRs for HMGB1 (show HMGB1 Proteins) in M1-type inflammatory macrophages
Our findings demonstrated that ClC-3 (show CLCN3 Proteins) deficiency inhibits atherosclerotic lesion development, possibly via suppression of JNK (show MAPK8 Proteins)/p38 MAPK (show MAPK14 Proteins) dependent SR-A expression and foam cell formation
FAP (show FAP Proteins)-cleaved collagen is a substrate for SR-A-dependent macrophage adhesion.
Macrophages regulate FX plasma levels in an SR-AI-dependent manner.
The results of this results reveal that SRA has important clinical implications for TLR-targeted immunotherapeutical strategy in intracerebral hemorrhage.
these findings suggest that SR-A-mediated dsRNA internalization is independent of innate antiviral signaling.
Our findings imply that SR-A may be an important target for improving therapeutic strategies for type 1 diabetes.
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages.
macrophage scavenger receptor 1
, macrophage scavenger receptor types I and II-like
, macrophage acetylated LDL receptor I and II
, macrophage scavenger receptor type III
, macrophage scavenger receptor types I and II
, scavenger receptor class A member 1
, scavenger receptor class A, member 1
, scavenger receptor type A
, macrophage scavenger receptor type I