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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP1 Kits (105) and MMP1 Proteins (49) and many more products for this protein.
Showing 10 out of 334 products:
Mouse (Murine) Polyclonal MMP1 Primary Antibody for IHC, ELISA - ABIN1586066
Bonta, Matlung, Vos, Peters, Pannekoek, Bakker, de Vries: Nuclear receptor Nur77 inhibits vascular outward remodelling and reduces macrophage accumulation and matrix metalloproteinase levels. in Cardiovascular research 2010
Show all 3 references for ABIN1586066
Human Polyclonal MMP1 Primary Antibody for IHC (p), WB - ABIN181338
Birkedal-Hansen, Moore, Taylor, Bhown, Birkedal-Hansen: Monoclonal antibodies to human fibroblast procollagenase. Inhibition of enzymatic activity, affinity purification of the enzyme, and evidence for clustering of epitopes in the NH2-terminal end of the activated enzyme. in Biochemistry 1989
Show all 2 references for ABIN181338
Human Monoclonal MMP1 Primary Antibody for ICC, FACS - ABIN969287
Genevay, Finckh, Mezin, Tessitore, Guerne: Influence of cytokine inhibitors on concentration and activity of MMP-1 and MMP-3 in disc herniation. in Arthritis research & therapy 2010
Show all 2 references for ABIN969287
Human Monoclonal MMP1 Primary Antibody for ELISA, ICC - ABIN449883
Singh, Kindelberger, Nagymanyoki, Ng, Quick, Elias, Yamamoto, Fichorova, Fulop, Berkowitz: Matrix metalloproteinases and their inhibitors and inducer in gestational trophoblastic diseases and normal placenta. in Gynecologic oncology 2011
Human Polyclonal MMP1 Primary Antibody for IF (p), IHC (p) - ABIN668466
Lu, Cao, Liu, Li, Chen, Fu, Zhang, Liu, Luo, Wang, Li, Caterson: The effects of mycotoxins and selenium deficiency on tissue-engineered cartilage. in Cells, tissues, organs 2012
Human Polyclonal MMP1 Primary Antibody for IF, IHC (p) - ABIN655817
Beshir, Ren, Magpusao, Barone, Yeung, Fenteany: Raf kinase inhibitor protein suppresses nuclear factor-κB-dependent cancer cell invasion through negative regulation of matrix metalloproteinase expression. in Cancer letters 2010
Cow (Bovine) Polyclonal MMP1 Primary Antibody for IHC, WB - ABIN2777120
Montero, Orbe, Varo, Beloqui, Monreal, Rodríguez, Díez, Libby, Páramo: C-reactive protein induces matrix metalloproteinase-1 and -10 in human endothelial cells: implications for clinical and subclinical atherosclerosis. in Journal of the American College of Cardiology 2006
Human Monoclonal MMP1 Primary Antibody for FACS - ABIN4896251
Domeij, Modéer, Quezada, Yucel-Lindberg: Cell expression of MMP-1 and TIMP-1 in co-cultures of human gingival fibroblasts and monocytes: the involvement of ICAM-1. in Biochemical and biophysical research communications 2005
These data demonstrate that Mmp1 modulates PDF processing, which leads to daily structural remodeling and circadian behavior.
A primary function of Mmp1, under the control of the JNK (show MAPK8 Antibodies) pathway, is to promote basement membrane repair, which in turn may permit cell migration and the restoration of a continuous tissue.
Drosophila Mmp1 is involved in the regulation of ISC proliferation for maintenance of gut (show GUSB Antibodies) homeostasis
Study identified three genes, regeneration (rgn (show RGN Antibodies)), augmenter of liver regeneration (alr (show GFER Antibodies)) and Matrix metalloproteinase-1 (Mmp1) expressed specifically in blastema cells during disc regeneration.
The status of a carrier of mutated (G insertion) allele with regard to the 1G/2G polymorphism at position -1607 within the MMP1 gene may determine a pathological phenotype associated with a more severe clinical course of chronic rhinosinusitis with nasal polyps
Study investigated the association between MMP-1 -1607 1G/2G and MMP-3 (show MMP3 Antibodies) -1171 5A/6A genetic polymorphisms and etiological subtypes of ischemic stroke (IS) in the Han Chinese population; MMP-1 2G allele was associated with IS due to SAO, whereas patients with IS due to LAA were more likely carriers of the 5A variant in MMP-3 (show MMP3 Antibodies)
this study shows that sICOSL in the serum of healthy donors increases in an age-dependent manner and that the matrix metalloproteinase (show MMP20 Antibodies) inhibitor (MMPI) could suppress sICOSL production
In order to reveal the structural and conformational effects of mutations, a molecular dynamics (MD) study was performed of in silico mutated residues in the X-ray crystallographic structure of MMP-1 complexed with a collagen-model triple-helical peptide (THP (show UMOD Antibodies)). The results indicate an important role of the mutated residues in MMP-1 interactions with the THP (show UMOD Antibodies) and communication between the catalytic and the HPX (show HPX Antibodies) domains.
A significant association has been found between MMP-1 -1607 1G/2G polymorphism and the susceptibility of endometriosis and adenomyosis under recessive model, while no significant association was found for MMP-2 (show MMP2 Antibodies) -735 C/T, MMP-3 (show MMP3 Antibodies) -1171 5A/6A and MMP-9 (show MMP9 Antibodies) -1562 C/T polymorphisms. (Meta-analysis)
infiltrative pulmonary tuberculosis is characterized by impairements in the system MMP/inhibitors: the levels of MMP-1, -9 increased, MMP-3 (show MMP3 Antibodies), -8, TIMP-1 (show TIMP1 Antibodies) remained at the reference values and a 2-macroglobulin was low.
Serum MMP-1 level showed a possibility as a prognostic biomarker in non-small cell lung cancer.
Melatonin decreased CXCL10 (show CXCL10 Antibodies) and MMP-1 production and increased TIMP-1 (show TIMP1 Antibodies) production in IL-1beta (show IL1B Antibodies)-stimulated Human Periodontal Ligament Cells
MMP1 expression is significantly upregulated in human masticatory mucosa during wound healing
Increased expression of TREM-1 (show TREM1 Antibodies) in S compared to AS patients involving TNFa (show TNF Antibodies), MMP-1 and MMP-9 (show MMP9 Antibodies) suggest a potential role of TREM-1 (show TREM1 Antibodies) in plaque destabilization
the identification of MMP1 and MMP10 (show MMP10 Antibodies) genes in swine is reported.
increased interstitial MMP1 activity during ischemia and reperfusion is a result of the endothelin protein kinase c (show PKC Antibodies) pathway and may be due to enhanced phosphorylation of mmp1
Results indicate that leukemia inhibitory factor (LIF (show LIF Antibodies)) and Oncostatin M (show OSM Antibodies) increase the expression of MMP-1, MMP-3 (show MMP3 Antibodies), and TIMP-1 (show TIMP1 Antibodies) several fold, and that their expression is reduced to basal levels in the presence of the LIF (show LIF Antibodies) antagonist MH35-BD.
The expression patterns of MMP1, MMP2 (show MMP2 Antibodies), and MMP8 (show MMP8 Antibodies) were explored during fetal and postnatal development of longissimus dorsi muscle in cattle, and the relationships of MMP1, MMP2 (show MMP2 Antibodies), and MMP8 (show MMP8 Antibodies) expression levels with meat quality traits were analyzed in cattle. The expression of MMP1, MMP2 (show MMP2 Antibodies), and MMP8 (show MMP8 Antibodies) were also tested in four kinds of fat tissues and three kinds of skeletal muscle tissues.
Data suggest that luteolytic factors (such as interferon gamma (show IFNG Antibodies), tumor necrosis factor alpha (show TNF Antibodies), and PGF2a) control expression of MMP1, other matrix metalloproteinases, and tissue inhibitors of metalloproteinase in cultured luteal cells.
The results showed that a decrease in MMP-1 and MMP-2 (show MMP2 Antibodies) gene expression is accompanied with a decrease in NO concentrations in infertile cows affected with ovarian cysts.
Cytoskeletal tension modulates MMP-1 gene expression from tenocytes on micropillar substrates.
MMP-1 promotes VEGFR2 (show KDR Antibodies) expression and proliferation of endothelial cells through stimulation of PAR-1 (show F2R Antibodies) and activation of NF-kappaB (show NFKB1 Antibodies)
These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
the differential expression and localization of membrane-type 1 matrix metalloproteinase (show MMP14 Antibodies) in the corpus luteum suggest that it may have multiple functions throughout the course of the estrous cycle,including activation of pro-MMP-2 (show MMP2 Antibodies)
increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 and MMP-13 (show MMP13 Antibodies) (follicular apex (show APEX1 Antibodies) vs. base) for the preovulatory collagenolysis required for follicle rupture
identification of MT1-MMP (show MMP14 Antibodies) in odontoclasts during deciduous tooth resorption might be relevant to the migration activity that these cells have to gain access to the root surface
MT1-MMP (show MMP14 Antibodies) has a role in signaling events mediating EGFR (show EGFR Antibodies) transactivation
Circulating smoke components, including acrolein, contribute to vascular diseases through enhanced MMP-1 and decreased TIMP-3 (show TIMP3 Antibodies) secretion.
ANXA2 (show ANXA2 Antibodies) and MMP1 might participate in remodeling during wound healing in the horse.
The polymorphism in the promoter of the MMP-1 gene could be a risk factor for early implant failure of total hip arthroplasty.
These results suggest that MMP-1 and IL-8 (show IL8 Antibodies) are both involved in the exercise-induced stress response, and this represents a starting point from which to understand the adaptive responses to this phenomenon.
Our study contributes to the understanding of the role of HIF1alpha (show HIF1A Antibodies) in OA and highlights the HIF1alpha (show HIF1A Antibodies)-beta-catenin (show CTNNB1 Antibodies) interaction, thus providing new insights into the impact of hypoxia in articular cartilage.
Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1/protease-activated receptor-1 (show F2R Antibodies) axis may play a role in neurogenesis following physiological and/or pathological stimuli.
IL-1Ra (show IL1RN Antibodies) is associated with MMP-13 (show MMP13 Antibodies) expression and has a novel function in such regulation without interference of the IL-1 (show IL1A Antibodies) signaling cascade.
We reveal a novel role of AP-2epsilon in the regulation of gene expression in articular chondrocytes, as well as in osteoarthritis development, through modulation of Mmp13 (show MMP13 Antibodies) expression and activity.
B-16 melanoma cells with up-regulated MMP-13 (show MMP13 Antibodies) expression promoted invasion of tumor cells through Matrigel compared with control cells transfected with empty vector. Knocked-down MMP-13 (show MMP13 Antibodies) expression also decreased invading cell numbers.
MMP-12 (show MMP12 Antibodies) and MMP-13 (show MMP13 Antibodies) alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.
Data indicate that tamoxifen decreased collage type II COL2A1 (show COL2A1 Antibodies) by activating matrix metallopeptidases MMP-2 (show MMP2 Antibodies)/13 expression.
This study demonstrates that stromal as well as tumor derived MMP13 (show MMP13 Antibodies) contribute to tumor cell extravasation and establishment of metastases in the liver microenvironment.
Elevated MMP13 (show MMP13 Antibodies) activity may contribute to Pseudomonas aeruginosa keratitis through basement membrane degradation.
Mmp13 (show MMP13 Antibodies) gene is regulated via at least three specific distal enhancers that display independent activities yet are able to integrate response from multiple signaling pathways in a model of activation and suppression.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.
, matrix metalloprotease 1
, matrix metalloproteinase 1
, matrix metalloproteinase-1
, fibroblast collagenase
, interstitial collagenase
, matrix metalloproteinase 1 (type I collagenase)
, matrix metalloproteinase-18
, collagenase 3
, matrix metalloproteinase 13
, matrix metalloproteinase-13