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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as art. Additionally we are shipping Matrix Metallopeptidase 13 (Collagenase 3) Kits (111) and Matrix Metallopeptidase 13 (Collagenase 3) Proteins (43) and many more products for this protein.
Showing 10 out of 263 products:
Human Polyclonal MMP13 Primary Antibody for EIA, IHC (p) - ABIN358686
Roy-Beaudry, Martel-Pelletier, Pelletier, MBarek, Christgau, Shipkolye, Moldovan: Endothelin 1 promotes osteoarthritic cartilage degradation via matrix metalloprotease 1 and matrix metalloprotease 13 induction. in Arthritis and rheumatism 2003
Show all 5 references for ABIN358686
Human Polyclonal MMP13 Primary Antibody for IF (p), IHC (p) - ABIN670341
Luo, Zhang, Wang, Hu, Song, Su, Zhang: Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats. in Bone 2013
Show all 3 references for ABIN670341
Human Monoclonal MMP13 Primary Antibody for IHC (p), IP - ABIN180404
Pei, Yi: A high-level mammalian expression system based on the Madin-Darby canine kidney cell line. in Protein expression and purification 1998
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Cow (Bovine) Polyclonal MMP13 Primary Antibody for IP, IHC - ABIN223238
Spinale, Escobar, Mukherjee, Zavadzkas, Saunders, Jeffords, Leone, Beck, Bouges, Stroud: Cardiac-restricted overexpression of membrane type-1 matrix metalloproteinase in mice: effects on myocardial remodeling with aging. in Circulation. Heart failure 2009
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Chicken Polyclonal MMP13 Primary Antibody for WB - ABIN2786656
Borghese, Chiche, Vernerey, Chenot, Mir, Bijaoui, Bonaiti-Pellié, Chapron: Genetic polymorphisms of matrix metalloproteinase 12 and 13 genes are implicated in endometriosis progression. in Human reproduction (Oxford, England) 2008
Show all 2 references for ABIN2786656
Human Polyclonal MMP13 Primary Antibody for IHC (p), WB - ABIN390137
Im, Pacione, Chubinskaya, Van Wijnen, Sun, Loeser: Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes. in The Journal of biological chemistry 2003
MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 (show MMP9 Antibodies) and Mmp13.
Zebra fish embryogenesis requires MMP-13 and dexamethasone and hydrocortisone modulate the expression of this gene, leading to increased activity and potentially contributing to subsequent dysmorphogenesis.
JNK (show MAPK8 Antibodies)-Mmp13 signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
XCL3 and XCL4 can be differentially induced by prolactin (show PRL Antibodies) and thyroid hormone (show PTH Antibodies)(3)
Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1 (show MMP1 Antibodies)/protease-activated receptor-1 (show F2R Antibodies) axis may play a role in neurogenesis following physiological and/or pathological stimuli.
IL-1Ra (show IL1RN Antibodies) is associated with MMP-13 expression and has a novel function in such regulation without interference of the IL-1 (show IL1A Antibodies) signaling cascade.
We reveal a novel role of AP-2epsilon in the regulation of gene expression in articular chondrocytes, as well as in osteoarthritis development, through modulation of Mmp13 expression and activity.
B-16 melanoma cells with up-regulated MMP-13 expression promoted invasion of tumor cells through Matrigel compared with control cells transfected with empty vector. Knocked-down MMP-13 exp (show LAMC2 Antibodies)ression also decreased invading cell numbers.
MMP-12 (show MMP12 Antibodies) and MMP-13 alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.
Data indicate that tamoxifen decreased collage type II COL2A1 (show COL2A1 Antibodies) by activating matrix metallopeptidases MMP-2 (show MMP2 Antibodies)/13 expression.
This study demonstrates that stromal as well as tumor derived MMP13 contribute to tumor cell extravasation and establishment of metastases in the liver microenvironment.
Elevated MMP13 activity may contribute to Pseudomonas aeruginosa keratitis through basement membrane degradation.
Mmp13 gene is regulated via at least three specific distal enhancers that display independent activities yet are able to integrate response from multiple signaling pathways in a model of activation and suppression.
Interferon (show IFNA Antibodies) alpha2b (show ADRA2B Antibodies) may exert anti-fibrotic effect by elevating the level of matrix metalloproteinase-13 and interleukin-10 (show IL10 Antibodies) in Kupffer cells, in a mitogen-activated protein kinase (show MAPK1 Antibodies) signaling pathways-dependent manner.
GP73 (show GOLM1 Antibodies) enhances MMP-13 expression through cAMP responsive element binding protein (CREB (show CREB1 Antibodies))-mediated transcription activation. Levels of GP73 (show GOLM1 Antibodies) and MMP-13 are increased and positively correlated in human HCC (show FAM126A Antibodies) tissues. Augmented MMP-13 potentiates HCC (show FAM126A Antibodies) cell metastasis.
SENP2 (show SUMO1 Antibodies) inhibits MMP13 expression in BC cells through de-SUMOylation of TBL1 (show TBL1X Antibodies)/TBLR1 (show TBL1XR1 Antibodies), which inhibits nuclear translocation of beta-catenin (show CTNNB1 Antibodies).
Hyaluronic acid exhibits a pronounced suppressive effect on MMP-13 expression in osteoarthritis.
Data show that blocking the interleukin-8 (IL-8 (show IL8 Antibodies))/androgen receptor (AR (show AR Antibodies))/matrix metalloproteinases (MMPs) signals partially reversed the infiltrating B cells capacity to increase the bladder cancer (BCa (show BLNK Antibodies)) cell invasion.
Elevated levels of MMP-13 may play a role in the pathogenesis of chronic periodontitis. There is a direct correlation of increased expression of MMP-13 with various clinical and histologic parameters in disease severity
Data show that the expression of transforming growth factor beta 1 (TGFB1 (show TGFB1 Antibodies)) was correlated with the expression of SMA- and MAD-related protein 3 (SMAD3 (show SMAD3 Antibodies)) and matrix metalloproteinase-13 (MMP13) in osteoarthritis (OA)-affected cartilage.
siRNA inhibited the effect of MMP13-containing exosomes on tumor cells metastasis as well as angiogenesis
RKIP (show PEBP1 Antibodies) Inhibits Local Breast Cancer Invasion by Antagonizing the Transcriptional Activation of MMP13
together, these data demonstrate that SERPINE2 (show SERPINE2 Antibodies) might prevent cartilage catabolism by inhibiting the expression of MMP-13, one of the most relevant collagenases, involved in cartilage breakdown in OA.
The DNA microarray analysis for matrix metalloproteinase (show MMP20 Antibodies) (MMP)-related mRNA expression in equine superficial digital flexor tendinitis indicated that mRNA level of MMP-13 was apparently up-regulated in the tendinitis as compared to normal tendon.
p38 (show MAPK14 Antibodies) phosphorylation and MMP13 expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
MMP-13 treatment of fresh articular cartilage results in cleaved fibromodulin (show FMOD Antibodies) fragments
increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 (show MMP1 Antibodies) and MMP-13 (follicular apex (show APEX1 Antibodies) vs. base) for the preovulatory collagenolysis required for follicle rupture
involvement of p38 MAP kinase (show MAPK14 Antibodies) in the hyaluronan oligosaccharide induction of MMP-13
MMP-13 and collagenase have roles in chondrocyte hypertrophy induced by type II collagen (show COL2A1 Antibodies)
At high but naturally occurring concentrations the collagen peptide CB12 (show PABPC4 Antibodies)-II induced an increase in the expressions of MMP-13 and cleavage of type II collagen (show COL2A1 Antibodies) by collagenase in the mid zone and also in the superficial zone.
chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 (show MMP3 Antibodies) and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.
Leptin (show LEP Antibodies) can induce MMP-13 and have a synergistic induction effect on NO with TNF-alpha (show TNF Antibodies) in rabbit articular chondrocytes in vitro.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
matrix metalloproteinase 13
, matrix metallopeptidase 13 (collagenase 3)
, collagenase 3
, gene A
, gene 11
, collagenase 3-like
, interstitial collagenase
, matrix metalloproteinase-13
, matrix metalloproteinase 13 (collagenase 3)