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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as art. Additionally we are shipping Matrix Metallopeptidase 13 (Collagenase 3) Kits (117) and Matrix Metallopeptidase 13 (Collagenase 3) Proteins (47) and many more products for this protein.
Showing 10 out of 274 products:
Human Polyclonal MMP13 Primary Antibody for EIA, IHC (p) - ABIN358686
Roy-Beaudry, Martel-Pelletier, Pelletier, MBarek, Christgau, Shipkolye, Moldovan: Endothelin 1 promotes osteoarthritic cartilage degradation via matrix metalloprotease 1 and matrix metalloprotease 13 induction. in Arthritis and rheumatism 2003
Show all 5 references for ABIN358686
Human Polyclonal MMP13 Primary Antibody for IF (p), IHC (p) - ABIN670341
Luo, Zhang, Wang, Hu, Song, Su, Zhang: Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats. in Bone 2013
Show all 3 references for ABIN670341
Human Monoclonal MMP13 Primary Antibody for IHC (p), IP - ABIN180404
Pei, Yi: A high-level mammalian expression system based on the Madin-Darby canine kidney cell line. in Protein expression and purification 1998
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Cow (Bovine) Polyclonal MMP13 Primary Antibody for IP, IHC - ABIN223238
Spinale, Escobar, Mukherjee, Zavadzkas, Saunders, Jeffords, Leone, Beck, Bouges, Stroud: Cardiac-restricted overexpression of membrane type-1 matrix metalloproteinase in mice: effects on myocardial remodeling with aging. in Circulation. Heart failure 2009
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Chicken Polyclonal MMP13 Primary Antibody for WB - ABIN2786656
Borghese, Chiche, Vernerey, Chenot, Mir, Bijaoui, Bonaiti-Pellié, Chapron: Genetic polymorphisms of matrix metalloproteinase 12 and 13 genes are implicated in endometriosis progression. in Human reproduction (Oxford, England) 2008
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Human Polyclonal MMP13 Primary Antibody for IHC (p), WB - ABIN390137
Im, Pacione, Chubinskaya, Van Wijnen, Sun, Loeser: Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes. in The Journal of biological chemistry 2003
Cow (Bovine) Polyclonal MMP13 Primary Antibody for ICC, IF - ABIN4334942
Ma, Liu, Wang, Chen, Liu, Li, Xiang, Wei, Duan, Han: Tamoxifen induces the development of hernia in mice by activating MMP-2 and MMP-13 expression. in Biochimica et biophysica acta 2015
MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 (show MMP9 Antibodies) and Mmp13.
Zebra fish embryogenesis requires MMP-13 and dexamethasone and hydrocortisone modulate the expression of this gene, leading to increased activity and potentially contributing to subsequent dysmorphogenesis.
JNK (show MAPK8 Antibodies)-Mmp13 signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
XCL3 and XCL4 can be differentially induced by prolactin (show PRL Antibodies) and thyroid hormone (show PTH Antibodies)(3)
Our study contributes to the understanding of the role of HIF1alpha (show HIF1A Antibodies) in OA and highlights the HIF1alpha (show HIF1A Antibodies)-beta-catenin (show CTNNB1 Antibodies) interaction, thus providing new insights into the impact of hypoxia in articular cartilage.
Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1 (show MMP1 Antibodies)/protease-activated receptor-1 (show F2R Antibodies) axis may play a role in neurogenesis following physiological and/or pathological stimuli.
IL-1Ra (show IL1RN Antibodies) is associated with MMP-13 expression and has a novel function in such regulation without interference of the IL-1 (show IL1A Antibodies) signaling cascade.
We reveal a novel role of AP-2epsilon in the regulation of gene expression in articular chondrocytes, as well as in osteoarthritis development, through modulation of Mmp13 expression and activity.
B-16 melanoma cells with up-regulated MMP-13 expression promoted invasion of tumor cells through Matrigel compared with control cells transfected with empty vector. Knocked-down MMP-13 expression also decreased invading cell numbers.
MMP-12 (show MMP12 Antibodies) and MMP-13 alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.
Data indicate that tamoxifen decreased collage type II COL2A1 (show COL2A1 Antibodies) by activating matrix metallopeptidases MMP-2 (show MMP2 Antibodies)/13 expression.
This study demonstrates that stromal as well as tumor derived MMP13 contribute to tumor cell extravasation and establishment of metastases in the liver microenvironment.
Elevated MMP13 activity may contribute to Pseudomonas aeruginosa keratitis through basement membrane degradation.
Mmp13 gene is regulated via at least three specific distal enhancers that display independent activities yet are able to integrate response from multiple signaling pathways in a model of activation and suppression.
In osteoarthritis (OA) chondrocytes, hydrostatic pressure (HP) restores the expression levels of some miRNAs, downregulates MMP-13, ADAMTS-5 (show ADAMTS5 Antibodies), and HDAC-4 (show HDAC4 Antibodies), and modulates the Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) pathway activation.
These results suggested that HIF-2alpha (show EPAS1 Antibodies) may cause meniscal matrix degradation by transactivation of MMP-13
TGF-beta1 (show TGFB1 Antibodies) stimulated a sustained and prolonged expression of ATF-3 (show ATF3 Antibodies), and its interaction and regulation of c-Jun protein (show JUN Antibodies) and their assembly as a protein complex at the AP-1 (show FOSB Antibodies) site of the MMP-13 promoter could be responsible for MMP-13 gene activation in MDA-MB231 cells.
Serum MMP13 did not differ significantly between normal weight, overweight, and obese participants.
No significant association was observed in MMP13, TIMP2 (show TIMP2 Antibodies) and TGFB3 (show TGFB3 Antibodies) genes with CP or PI. CP is a risk factor to develop PI, however, there is no association of both diseases with polymorphisms in the MMP13, TIMP2 (show TIMP2 Antibodies) and TGFB3 (show TGFB3 Antibodies) genes
Findings suggest thatSirt1 may regulate the expression of Runx2 (show RUNX2 Antibodies), which is the osteogenic transcription factor, and the production of MMP-13 from chondrocytes in OA.
the mechanisms and roles of MMP-13 secretion in human small airway epithelial cells and functional polymorphisms of the MMP13 gene
as the grade of late-stage osteoarthritis advanced, levels of TNF-alpha (show TNF Antibodies) in the serum became elevated, whereas levels of MMP-13 in the synovial fluid became elevated
As the grade of late stage osteoarthritis advances, increase in synovial MMP-13 and serum TNF-a (show TNF Antibodies) levels become pronounced.
High MMP13 serum levels are associated with Esophageal Squamous Cell Carcinoma.
The DNA microarray analysis for matrix metalloproteinase (show MMP20 Antibodies) (MMP)-related mRNA expression in equine superficial digital flexor tendinitis indicated that mRNA level of MMP-13 was apparently up-regulated in the tendinitis as compared to normal tendon.
p38 (show MAPK14 Antibodies) phosphorylation and MMP13 expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
MMP-13 treatment of fresh articular cartilage results in cleaved fibromodulin (show FMOD Antibodies) fragments
increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 (show MMP1 Antibodies) and MMP-13 (follicular apex (show APEX1 Antibodies) vs. base) for the preovulatory collagenolysis required for follicle rupture
involvement of p38 MAP kinase (show MAPK14 Antibodies) in the hyaluronan oligosaccharide induction of MMP-13
MMP-13 and collagenase have roles in chondrocyte hypertrophy induced by type II collagen (show COL2A1 Antibodies)
At high but naturally occurring concentrations the collagen peptide CB12 (show PABPC4 Antibodies)-II induced an increase in the expressions of MMP-13 and cleavage of type II collagen (show COL2A1 Antibodies) by collagenase in the mid zone and also in the superficial zone.
chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 (show MMP3 Antibodies) and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.
Leptin (show LEP Antibodies) can induce MMP-13 and have a synergistic induction effect on NO with TNF-alpha (show TNF Antibodies) in rabbit articular chondrocytes in vitro.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
matrix metalloproteinase 13
, matrix metallopeptidase 13 (collagenase 3)
, collagenase 3
, gene A
, gene 11
, collagenase 3-like
, interstitial collagenase
, matrix metalloproteinase-13
, matrix metalloproteinase 13 (collagenase 3)