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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping Matrix Metallopeptidase 13 (Collagenase 3) Kits (144) and Matrix Metallopeptidase 13 (Collagenase 3) Proteins (42) and many more products for this protein.
Showing 10 out of 290 products:
Human Polyclonal MMP13 Primary Antibody for IF (p), IHC (p) - ABIN670341
Luo, Zhang, Wang, Hu, Song, Su, Zhang: Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats. in Bone 2013
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Cow (Bovine) Polyclonal MMP13 Primary Antibody for IP, IHC - ABIN223238
Spinale, Escobar, Mukherjee, Zavadzkas, Saunders, Jeffords, Leone, Beck, Bouges, Stroud: Cardiac-restricted overexpression of membrane type-1 matrix metalloproteinase in mice: effects on myocardial remodeling with aging. in Circulation. Heart failure 2009
Show all 2 Pubmed References
Cow (Bovine) Polyclonal MMP13 Primary Antibody for ICC, IF - ABIN4334942
Ma, Liu, Wang, Chen, Liu, Li, Xiang, Wei, Duan, Han: Tamoxifen induces the development of hernia in mice by activating MMP-2 and MMP-13 expression. in Biochimica et biophysica acta 2015
Human Polyclonal MMP13 Primary Antibody for ICC, IF - ABIN4334943
Huang, Ao, Li, Wu, Xu, Deng, Chen, Yin, Cheng: Autophagy Protects Advanced Glycation End Product-Induced Apoptosis and Expression of MMP-3 and MMP-13 in Rat Chondrocytes. in BioMed research international 2017
Cow (Bovine) Polyclonal MMP13 Primary Antibody for WB - ABIN2786656
Borghese, Chiche, Vernerey, Chenot, Mir, Bijaoui, Bonaiti-Pellié, Chapron: Genetic polymorphisms of matrix metalloproteinase 12 and 13 genes are implicated in endometriosis progression. in Human reproduction (Oxford, England) 2008
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Rat (Rattus) Polyclonal MMP13 Primary Antibody for ICC, IHC - ABIN1172288
Chu, Dai, Wang, Tian, Song, Xiao, Shao, Zhang, Zhang: Strontium ranelate causes osteophytes overgrowth in a model of early phase osteoarthritis. in BMC musculoskeletal disorders 2017
TGF-beta1 (show TGFB1 Antibodies) stimulates the phosphorylation of Runx2 (show RUNX2 Antibodies) at three serine amino acids, and this event is required for MMP-13 expression in osteoblastic cells.
IL-6 (show IL6 Antibodies)-stimulated MMP-13 expression was independent of IL-1beta (show IL1B Antibodies) stimulation and was blocked by SAHA, suggesting that SAHA inhibits IL-6 (show IL6 Antibodies) signaling in Osteoarthritis (OA) chondrocytes.
High MMP13 expression is associated with intervertebral disc degeneration.
data demonstrate that MMP-13 is critical for the development of osteolytic lesions in Multiple myeloma and that targeting the MMP-13 protein - rather than its catalytic activity - constitutes a potential approach to mitigating bone disease in affected patients.
Endoplasmic reticulum stress participates in the progress of senescence and apoptosis of osteoarthritic chondrocytes, which manifested in increased expression of ADAMTS5 (show ADAMTS5 Antibodies), MMP13, and decreased COL2A1 (show COL2A1 Antibodies) expression.
Matrix metalloprotease (MMP) regulation was the top pathway involved in gingival aging. MMP3 (show MMP3 Antibodies), MMP9 (show MMP9 Antibodies), MMP12 (show MMP12 Antibodies), and MMP13 were upregulated in old gingival tissues, concomitantly with interleukin-1 beta (IL1B (show IL1B Antibodies)) expression.
these findings support roles for both cFOS (indirect) and ATF3 (show ATF3 Antibodies) (direct) in effecting MMP13 transcription in human chondrocytes.
Oxytocin prevents cartilage matrix destruction via regulating MMP1 (show MMP1 Antibodies) and MMP13.
These studies have uncovered a new, ATP6V1H (show ATP6V1H Antibodies)-mediated pathway that regulates bone formation, and defines a new mechanism of disease that leads to bone loss. We propose that MMP9 (show MMP9 Antibodies)/MMP13 could be therapeutic targets for patients with this rare genetic disease.
To conclude, Pseudomonas aeruginosa infection induced the expression of matrix metalloproteinases, and Pseudomonas aeruginosa type III secretion system appeared to be a key player in MMP-12 (show MMP12 Antibodies) and MMP-13 expression, which is further controlled by NF-kappaB (show NFKB1 Antibodies) signaling.
the phenotype seen in the Hdac4 (show HDAC5 Antibodies)(-/-) mice is partially derived from elevation in MMP-13 and may be due to a bone remodeling disorder caused by overexpression of this enzyme.
MEF2C (show MEF2C Antibodies) is necessary for Mmp13 gene expression at the transcriptional level and participates in PTH (show PTH Antibodies)-stimulated Mmp13 gene expression by increased binding to c-FOS at the AP-1 (show JUN Antibodies) site in the Mmp13 promoter.
data reveal a novel involvement of MMP-13 in regulating dendritic cell (DC) immunobiology through moderating MHC-I surface presentation, endocytosis and cytokine/chemokine (show CCL1 Antibodies) secretion; furthermore, the reduced MHC-I surface presentation by DCs resulted in a poor CD8 (show CD8A Antibodies)(+) T-cell response in vitro; MMP-13 might be a promising target for therapeutic intervention in inflammatory diseases
The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2 (show DDR2 Antibodies)-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 (show DDR2 Antibodies) and matrix metalloproteinase 13.
Postnatal chondrocyte-specific deletion of Hdac3 (show HDAC3 Antibodies) with an inducible Col2a1 (show COL2A1 Antibodies)-Cre caused premature production of pErk1/2 and Mmp13 in the growth plate.
Mmp13 is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (show PTH Antibodies), and Osterix (show SP7 Antibodies) through distal enhancers.
Our study contributes to the understanding of the role of HIF1alpha (show HIF1A Antibodies) in OA and highlights the HIF1alpha (show HIF1A Antibodies)-beta-catenin (show CTNNB1 Antibodies) interaction, thus providing new insights into the impact of hypoxia in articular cartilage.
Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1 (show MMP1 Antibodies)/protease-activated receptor-1 (show F2R Antibodies) axis may play a role in neurogenesis following physiological and/or pathological stimuli.
IL-1Ra (show IL1RN Antibodies) is associated with MMP-13 expression and has a novel function in such regulation without interference of the IL-1 (show IL1A Antibodies) signaling cascade.
We reveal a novel role of AP-2epsilon in the regulation of gene expression in articular chondrocytes, as well as in osteoarthritis development, through modulation of Mmp13 expression and activity.
p38 (show MAPK14 Antibodies) phosphorylation and MMP13 expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
MMP-13 treatment of fresh articular cartilage results in cleaved fibromodulin (show FMOD Antibodies) fragments
increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 (show MMP1 Antibodies) and MMP-13 (follicular apex (show APEX1 Antibodies) vs. base) for the preovulatory collagenolysis required for follicle rupture
involvement of p38 MAP kinase (show MAPK14 Antibodies) in the hyaluronan oligosaccharide induction of MMP-13
MMP-13 and collagenase have roles in chondrocyte hypertrophy induced by type II collagen (show COL2A1 Antibodies)
At high but naturally occurring concentrations the collagen peptide CB12 (show PABPC4 Antibodies)-II induced an increase in the expressions of MMP-13 and cleavage of type II collagen (show COL2A1 Antibodies) by collagenase in the mid zone and also in the superficial zone.
XCL3 and XCL4 can be differentially induced by prolactin (show PRL Antibodies) and thyroid hormone (show PTH Antibodies)(3)
MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 (show MMP9 Antibodies) and Mmp13.
Zebra fish embryogenesis requires MMP-13 and dexamethasone and hydrocortisone modulate the expression of this gene, leading to increased activity and potentially contributing to subsequent dysmorphogenesis.
JNK (show MAPK8 Antibodies)-Mmp13 signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
These results suggest that PEP-1-SIRT2 (show SIRT2 Antibodies) promotes matrix metalloproteinases-induced dedifferentiation via ERK (show MAPK1 Antibodies) signaling in articular chondrocytes.
chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 (show MMP3 Antibodies) and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.
Leptin (show LEP Antibodies) can induce MMP-13 and have a synergistic induction effect on NO with TNF-alpha (show TNF Antibodies) in rabbit articular chondrocytes in vitro.
The DNA microarray analysis for matrix metalloproteinase (MMP)-related mRNA expression in equine superficial digital flexor tendinitis indicated that mRNA level of MMP-13 was apparently up-regulated in the tendinitis as compared to normal tendon.
TNF-alpha (show TNF Antibodies) induced MMP-13 expression by condylar cells might be involved in the degradation of the juvenile condyle.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
, collagenase 3
, matrix metalloproteinase 13 (collagenase 3)
, interstitial collagenase
, matrix metalloproteinase 13
, matrix metalloproteinase-13
, gene 11
, matrix metallopeptidase 13 (collagenase 3)
, gene A
, collagenase 3-like