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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Additionally we are shipping MMP8 Kits (89) and MMP8 Proteins (25) and many more products for this protein.
Showing 10 out of 164 products:
Human Polyclonal MMP8 Primary Antibody for EIA, IHC (p) - ABIN358702
Van den Steen, Husson, Proost, Van Damme, Opdenakker: Carboxyterminal cleavage of the chemokines MIG and IP-10 by gelatinase B and neutrophil collagenase. in Biochemical and biophysical research communications 2003
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Human Polyclonal MMP8 Primary Antibody for IF (p), IHC (p) - ABIN736283
Zhang, Li, Zhang, Fu, Cui: Hydrogen sulfide suppresses the expression of MMP-8, MMP-13, and TIMP-1 in left ventricles of rats with cardiac volume overload. in Acta pharmacologica Sinica 2013
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Human Polyclonal MMP8 Primary Antibody for IHC, IHC (p) - ABIN4335077
Ong, Elkington, Brilha, Ugarte-Gil, Tome-Esteban, Tezera, Pabisiak, Moores, Sathyamoorthy, Patel, Gilman, Porter, Friedland: Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis. in PLoS pathogens 2015
Human Monoclonal MMP8 Primary Antibody for FACS, IHC - ABIN4899598
Arechavaleta-Velasco, Marciano, Díaz-Cueto, Parry: Matrix metalloproteinase-8 is expressed in human chorion during labor. in American journal of obstetrics and gynecology 2004
Human Polyclonal MMP8 Primary Antibody for IP, IHC - ABIN223233
Ikonomidis, Jones, Barbour, Stroud, Clark, Kaplan, Zeeshan, Bavaria, Gorman, Spinale, Gorman: Expression of matrix metalloproteinases and endogenous inhibitors within ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valves. in The Journal of thoracic and cardiovascular surgery 2007
Human Polyclonal MMP8 Primary Antibody for IHC (p), WB - ABIN390153
Massova, Kotra, Fridman, Mobashery: Matrix metalloproteinases: structures, evolution, and diversification. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 1998
MMP8 plays an important role in intestinal I/R injury through mechanisms involving increased inflammation and loss of claudin-3 (show CLDN3 Antibodies)
These results suggest that some of the anti-inflammatory effects of Dexamethasone are mediated through increased MMP-8 expression.
These results suggest a novel pathogenetic role of MMP8 and implicate modulation of its activity as a tractable strategy for therapies against cerebral ischemia.
Fusion peptide inhibitors of MMP-8/-9 prevent endotoxic shock if administered within a strict time window.
the loss of MMP-8 likely has pleiotropic effects on innate immunity and angiogenesis that are reflected in changes in the protease web.
A previously unknown role of MMP8 in M2-macrophage polarization by cleaving fibromodulin (show FMOD Antibodies) and therefore increasing the bioavailability of TGF-beta (show TGFB1 Antibodies).
MMP-8-deficient mice had significantly lower serum triglyceride (TG) levels (P = 0.003) and larger HDL (show HSD11B1 Antibodies) particles compared with wild-type (WT) mice. However, no differences were observed in the apoA-I (show APOA1 Antibodies) levels.
These results demonstrate that MMP-8 critically mediates microglial activation by modulating TNF-alpha (show TNF Antibodies) activity, which may explain neuroinflammation in septic mouse brain.
MMP-13 (show MMP13 Antibodies) prevails over MMP-8 in collagen degradation in atheromata.
MMP8 enhances vascular smooth muscle cell proliferation via an ADAM10 (show ADAM10 Antibodies), N-cadherin (show CDH2 Antibodies), and beta-catenin (show CTNNB1 Antibodies)-mediated pathway and plays an important role in neointima formation.
Low MMP-8/TIMP-1 (show TIMP1 Antibodies) reflects left ventricle impairment in takotsubo cardiomyopathy and high TIMP-1 (show TIMP1 Antibodies) may help to differentiate it from acute coronary syndrome
Plasma levels of MMP-1 (show MMP1 Antibodies), MMP-8, and MMP-9 (show MMP9 Antibodies) are associated with COPD (show ARCN1 Antibodies) severity and can be used as a biomarker to better understand the characteristics of COPD (show ARCN1 Antibodies) patients.
there is a negative correlation between blood MMP8 and HDL (show HSD11B1 Antibodies)-cholesterol levels, suggesting a contributory role of MMP8 in metabolic alterations in acne inversa
plasma concentrations of MMP-7 (show MMP7 Antibodies), MMP-8, -9 and TIMP-1 (show TIMP1 Antibodies) within 96 h from the onset of acute pancreatitis symptoms are elevated in acute pancreatitis patients compared with healthy controls
MMP-8 is a vital component of the myoepithelial tumour-suppressor function. It restores MEC (show CCL28 Antibodies) interaction with the matrix, opposes TGF-beta (show TGFB1 Antibodies) signalling and MMP-9 (show MMP9 Antibodies) proteolysis, which contributes to inhibition of tumour cell invasion.
a 7-gene signature was identified which correctly predicted the primary prefibrotic myelofibrosis group with a sensitivity of 100% and a specificity of 89%. The 7 genes included MPO (show MPO Antibodies), CEACAM8, CRISP3 (show CRISP3 Antibodies), MS4A3 (show MS4A3 Antibodies), CEACAM6, HEMGN, and MMP8
Obesity is associated with elevated circulating MMP-8 in young adults. MMP-8 is also increased in smokers.
infiltrative pulmonary tuberculosis is characterized by impairements in the system MMP/inhibitors: the levels of MMP-1 (show MMP1 Antibodies), -9 increased, MMP-3 (show MMP3 Antibodies), -8, TIMP-1 (show TIMP1 Antibodies) remained at the reference values and a 2-macroglobulin was low.
Serum level patterns of MMP-2 (show MMP2 Antibodies) and MMP-8 showed distinctive patterns for patients with spinal cord injury neurological impairment. MMP-8 and MMP-9 (show MMP9 Antibodies) patterns showed significant differences regarding functional recovery. Our binary logistic regression model showed that, according to neurological damage, measuring peripheral serum levels can be used to monitor and predict locomotor recovery after spinal cord injury.
Blood expression of matrix metalloproteinases 8 and 9 and of their inducers S100A8 (show S100A8 Antibodies) and S100A9 (show S100A9 Antibodies) supports diagnosis and prognosis of PDAC-associated diabetes mellitus
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
matrix metallopeptidase 8 (neutrophil collagenase)
, matrix metalloproteinase 8
, collagenase 2
, matrix metalloproteinase-8
, neutrophil collagenase
, neutrophil collagenease
, PMNL collagenase
, matrix metalloproteinase 8 (neutrophil collagenase)