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anti-Megakaryoblastic Leukemia (Translocation) 1 (MKL1) Antibodies

The protein encoded by MKL1 interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MKL1 57591 Q969V6
MKL1 315151  
MKL1 223701 Q8K4J6
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Top anti-MKL1 Antibodies at antibodies-online.com

Showing 10 out of 74 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated WB WB Suggested Anti-MKL1 Antibody Titration: 1.25ug/mlELISA Titer: 1:1562500Positive Control: NIH/3T3 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Mouse Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HuvEc/HeLa cells, using MKL1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Mouse Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse brain labeled with Rabbit Anti Mkl1/MRTF-A Polyclonal Antibody, Unconjugated (ABIN1387286) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse lung labeled with Rabbit Anti Mkl1/MRTF-A Polyclonal Antibody, Unconjugated (ABIN1387286) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Rabbit Un-conjugated WB MKL1 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MKL1 antibody detected the MKL1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Mouse Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 2 to 3 Days
$343.75
Details
Human Rabbit Alexa Fluor 555 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details
Human Rabbit Alexa Fluor 488 IF (p)   100 μL Log in to see 14 to 21 Days
$357.50
Details

MKL1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-MKL1 Antibodies

  1. Chicken Polyclonal MKL1 Primary Antibody for WB - ABIN2780121 : Sasazuki, Sawada, Sakon, Kitamura, Kishi, Okazaki, Katano, Tanaka, Watanabe, Yagita, Okumura, Nakano: Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death. in The Journal of biological chemistry 2002 (PubMed)

More Antibodies against MKL1 Interaction Partners

Human Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. Study showed that MRTF-A and MRTF-B (show MKL2 Antibodies) were upregulated in pancreatic cancer tissues supporting the hypothesis that both of them are oncogenes in pancreatic cancer.

  2. FLNA (show FLNA Antibodies) functions as a positive cellular transducer linking actin polymerization to MKL1-SRF activity, counteracting the known repressive complex of MKL1 and monomeric G-actin (show ACTB Antibodies).

  3. Redox-sensitive regulation of MRTF-A phosphorylation via palladin (show PALLD Antibodies) in vascular smooth muscle cell differentiation marker gene expression.

  4. Identification of SAP (show APCS Antibodies)-dependent Mkl1 signaling as a previously unrecognized mediator of aggressive progression of mammary tumors locally relapsing after radiotherapy.

  5. MRTF-A is a critical for epithelial to mesenchymal transition and can be stereoselectively inhibited by CCG-1423.

  6. p300 (show EP300 Antibodies) and MRTF-A synergistically enhance the expression of migration-related genes in breast cancer cells.

  7. Myocardin-Related Transcription Factor A and Yes-Associated Protein Exert Dual Control in G protein-coupled receptor (show ADRA1A Antibodies)- and RhoA (show RHOA Antibodies)-mediated transcriptional regulation and cell proliferation

  8. Study found that MRTF-A expression was up-regulated in metastatic anaplastic thyroid cancer tissues and promoted metastasis-relevant traits in vitro.

  9. Ddx19 (show DDX19B Antibodies) is an RNA export factor required for nuclear import of the SRF coactivator MKL1

  10. AMPK (show PRKAA1 Antibodies) and Akt (show AKT1 Antibodies) activation are responsible for the CTRP6-mediated anti-fibrotic effect by targeting RhoA (show RHOA Antibodies)/MRTF-A pathway

Cow (Bovine) Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. beta-catenin (show CTNNB1 Antibodies) controls myocardin (show MYOCD Antibodies)-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes.

Mouse (Murine) Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. MRTF-A regulates liver fibrosis by epigenetically tuning the TGF-beta (show TGFB1 Antibodies) signaling pathway in HSCs

  2. Exploration of the molecular causes of enhanced cardiac hypertrophy revealed significant activation of beta-catenin/GSK-3beta signaling, whereas MAPK and MKL1/serum-response factor pathways were inhibited.

  3. MRTF-A is a critical for epithelial to mesenchymal transition and can be stereoselectively inhibited by CCG-1423.

  4. MKL1 plays a significant role in mediating the fibrotic response to bleomycin injury. Loss of MKL1 attenuated early neutrophil influx, as well as myofibroblast-mediated remodeling.

  5. MRTF-A/B depletion results in an increase in the cell surface expression of ICAM-1 (show ICAM1 Antibodies) and interactions between HAoECs and leukocytes

  6. knockdown of MRTF-A synthesis abolishes the systemic sclerosis myofibroblast enhanced basal contractility and synthesis of type I collagen and inhibits the matricellular profibrotic protein, connective tissue growth factor (CCN2/CTGF (show CTGF Antibodies)

  7. Either MRTF-A or MRTF-B (show MKL2 Antibodies) is dispensable for cardiac development, whereas deletion of both causes a spectrum of abnormalities ranging from reduced cardiac contractility and adult onset heart failure to neonatal lethality accompanied by sarcomere disarray.

  8. Ddx19 (show DDX19B Antibodies) is an RNA export factor required for nuclear import of the SRF coactivator MKL1

  9. Expression analysis showed that MKL1 is highly expressed in human and mouse brains; results revealed that genetic variants in MKL1 might confer risk to schizophrenia.

  10. Results found that MKL1 expression was upregulated during cell cycle arrest induced by a temperature switch in podocytes through p21 (show D4S234E Antibodies) transcription activation suggesting a physiological roles in the maturation and development of podocytes.

MKL1 Antigen Profile

Protein Summary

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.

Gene names and symbols associated with MKL1

  • megakaryoblastic leukemia 1 protein (MKL1) antibody
  • megakaryoblastic leukemia 1 protein (LOC100358994) antibody
  • megakaryoblastic leukemia 1 protein (mkl1) antibody
  • megakaryoblastic leukemia (translocation) 1 (MKL1) antibody
  • megakaryoblastic leukemia (translocation) 1 (Mkl1) antibody
  • megakaryoblastic leukemia (translocation) 1 (mkl1) antibody
  • MKL (megakaryoblastic leukemia)/myocardin-like 1 (Mkl1) antibody
  • AI852829 antibody
  • AMKL antibody
  • AW743281 antibody
  • AW821984 antibody
  • Bsac antibody
  • Mal antibody
  • MKL1 antibody
  • Mrtf-A antibody
  • mrtfa antibody

Protein level used designations for MKL1

megakaryoblastic leukemia 1 protein , MKL/myocardin-like protein 1 , RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein , basic, SAP and coiled-coil domain , megakaryocytic acute leukemia protein , myocardin-related transcription factor A , xMRTF-A , basic SAP and coiled-coil domains , basic SAP coiled-coil transcription activator , megakaryoblastic leukemia (translocation) 1 homolog , megakaryoblastic leukemia 1 protein homolog

GENE ID SPECIES
745765 Pan troglodytes
100358994 Oryctolagus cuniculus
100510767 Anolis carolinensis
418005 Gallus gallus
57591 Homo sapiens
509011 Bos taurus
315151 Rattus norvegicus
398403 Xenopus laevis
223701 Mus musculus
Selected quality suppliers for anti-MKL1 (MKL1) Antibodies
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