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The protein encoded by MKL1 interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. Additionally we are shipping and many more products for this protein.
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Chicken Polyclonal MKL1 Primary Antibody for WB - ABIN2780121
Sasazuki, Sawada, Sakon, Kitamura, Kishi, Okazaki, Katano, Tanaka, Watanabe, Yagita, Okumura, Nakano: Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death. in The Journal of biological chemistry 2002
FLNA (show FLNA Antibodies) functions as a positive cellular transducer linking actin polymerization to MKL1-SRF activity, counteracting the known repressive complex of MKL1 and monomeric G-actin (show ACTB Antibodies).
Redox-sensitive regulation of MRTF-A phosphorylation via palladin (show PALLD Antibodies) in vascular smooth muscle cell differentiation marker gene expression.
Identification of SAP (show APCS Antibodies)-dependent Mkl1 signaling as a previously unrecognized mediator of aggressive progression of mammary tumors locally relapsing after radiotherapy.
MRTF-A is a critical for epithelial to mesenchymal transition and can be stereoselectively inhibited by CCG-1423.
p300 (show EP300 Antibodies) and MRTF-A synergistically enhance the expression of migration-related genes in breast cancer cells.
Myocardin-Related Transcription Factor A and Yes-Associated Protein Exert Dual Control in G protein-coupled receptor (show ADRA1A Antibodies)- and RhoA (show RHOA Antibodies)-mediated transcriptional regulation and cell proliferation
Study found that MRTF-A expression was up-regulated in metastatic anaplastic thyroid cancer tissues and promoted metastasis-relevant traits in vitro.
Ddx19 (show DDX19B Antibodies) is an RNA export factor required for nuclear import of the SRF coactivator MKL1
AMPK (show PRKAA1 Antibodies) and Akt (show AKT1 Antibodies) activation are responsible for the CTRP6-mediated anti-fibrotic effect by targeting RhoA (show RHOA Antibodies)/MRTF-A pathway
MKL1 recruited ASH2 (show ASCL2 Antibodies), a component of the H3K4 methyltransferase complex, to activate MMP9 (show MMP9 Antibodies) transcription.
beta-catenin (show CTNNB1 Antibodies) controls myocardin (show MYOCD Antibodies)-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes.
Exploration of the molecular causes of enhanced cardiac hypertrophy revealed significant activation of beta-catenin/GSK-3beta signaling, whereas MAPK and MKL1/serum-response factor pathways were inhibited.
MKL1 plays a significant role in mediating the fibrotic response to bleomycin injury. Loss of MKL1 attenuated early neutrophil influx, as well as myofibroblast-mediated remodeling.
MRTF-A/B depletion results in an increase in the cell surface expression of ICAM-1 (show ICAM1 Antibodies) and interactions between HAoECs and leukocytes
knockdown of MRTF-A synthesis abolishes the systemic sclerosis myofibroblast enhanced basal contractility and synthesis of type I collagen and inhibits the matricellular profibrotic protein, connective tissue growth factor (CCN2/CTGF (show CTGF Antibodies)
Either MRTF-A or MRTF-B (show MKL2 Antibodies) is dispensable for cardiac development, whereas deletion of both causes a spectrum of abnormalities ranging from reduced cardiac contractility and adult onset heart failure to neonatal lethality accompanied by sarcomere disarray.
Expression analysis showed that MKL1 is highly expressed in human and mouse brains; results revealed that genetic variants in MKL1 might confer risk to schizophrenia.
Results found that MKL1 expression was upregulated during cell cycle arrest induced by a temperature switch in podocytes through p21 (show D4S234E Antibodies) transcription activation suggesting a physiological roles in the maturation and development of podocytes.
These data support a central role of the SRF/MRTF pathway in the pathobiology of lung fibrosis.
The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.
megakaryoblastic leukemia 1 protein
, MKL/myocardin-like protein 1
, RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein
, basic, SAP and coiled-coil domain
, megakaryocytic acute leukemia protein
, myocardin-related transcription factor A
, basic SAP and coiled-coil domains
, basic SAP coiled-coil transcription activator
, megakaryoblastic leukemia (translocation) 1 homolog
, megakaryoblastic leukemia 1 protein homolog