anti-Megakaryoblastic Leukemia (Translocation) 1 (MKL1) Antibodies

The protein encoded by MKL1 interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MKL1 57591 Q969V6
MKL1 315151  
MKL1 223701 Q8K4J6
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Top anti-MKL1 Antibodies at antibodies-online.com

Showing 10 out of 81 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-MKL1 Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>NIH/3T3 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Mouse Rabbit Un-conjugated ELISA, WB Western blot analysis of extracts from HuvEc/HeLa cells, using MKL1 Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: Mkl1 Antibody [NBP1-88498] - Staining of human cell line A-431 shows positivity in nucleus but not nucleoli. Immunohistochemistry-Paraffin: Mkl1 Antibody [NBP1-88498] - Immunohistochemical staining of human placenta shows strong nuclear positivity in decidual cells. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Cow Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded mouse brain labeled with Rabbit Anti Mkl1/MRTF-A Polyclonal Antibody, Unconjugated (ABIN1387286) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin embedded mouse lung labeled with Rabbit Anti Mkl1/MRTF-A Polyclonal Antibody, Unconjugated (ABIN1387286) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$306.90
Details
Human Rabbit Un-conjugated ELISA, IHC, WB 100 μL Log in to see 16 Days
$181.73
Details
Human Rabbit Un-conjugated WB MKL1 Antibody (Center) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the MKL1 antibody detected the MKL1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB <b>Western blot</b> (WB) analysis of MRTF-A antibody in extracts from HUVEC cells. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Cy5.5 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details
Human Rabbit Cy3 IF (p)   100 μL Log in to see 14 to 21 Days
$405.90
Details

MKL1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-MKL1 Antibodies

  1. Human Polyclonal MKL1 Primary Antibody for ICC, IF - ABIN4334827 : Schmidt, Duncan, Yadav, Regan, Verone, Lohse, Pop, Attwood, Wilding, Mohler, Sebo, Tindall, Heemers: RhoA as a mediator of clinically relevant androgen action in prostate cancer cells. in Molecular endocrinology (Baltimore, Md.) 2012 (PubMed)
    Show all 5 Pubmed References

More Antibodies against MKL1 Interaction Partners

Human Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. CytoD modified MKL1, a coactivator of serum response factor (SRF) regulating CTGF induction, and promoted its nuclear localization.

  2. HOTAIR is regulated by the RhoC-MRTF-A-SRF signaling pathway in breast cancer cells.

  3. TNF-alpha (show TNF Antibodies) and LPS (show IRF6 Antibodies) promoted the interaction between MKL1 and PCAF (show KAT2B Antibodies).

  4. MRTF-A-miR (show MLXIP Antibodies)-206-WDR1 (show WDR1 Antibodies) form feedback loop to regulate breast cancer cell migration.

  5. miR (show MLXIP Antibodies)-93-5p regulates myocardin-like (show MYOCD Antibodies) 1 and STAT3 (show STAT3 Antibodies) to affect epithelial-mesenchymal transition controlling breast cancer cell migration

  6. results highlight the critical role of the actin-regulated MRTF transcriptional pathway for bleb-associated invasive motility, such as during entosis.

  7. transcriptional co-activator MRTF-A and actin polymerization regulated a subset of miRNAs in vascular smooth muscle. Identification of novel miRNAs regulated by actin/MRTF-A may provide further insight into the mechanisms underlying vascular disease states, such as aortic aneurysm, as well as novel ideas regarding therapeutic strategies

  8. Data suggest 2 major isoforms of profilin (Pfn1 and Pfn2) are co-regulated by a common mechanism involving the action of MKL1 [megakaryoblastic leukemia (translocation) 1 protein] that is independent of its SRF- (serum-response factor)-related activity; cellular externalization of Pfn1, rather than transcription, is affected by the perturbations of MKL1; MKL1 can influence cell migration by modulating Pfn1 expression.

  9. RBM15 (show RBM15 Antibodies)-MKL1 fusion is associated with acute megakaryoblastic leukemia in non-Down syndrome.

  10. The authors show MRTF family proteins bind YAP (show YAP1 Antibodies) via a conserved PPXY motif that interacts with the YAP (show YAP1 Antibodies) WW domain (show DRP2 Antibodies). This interaction allows MRTF to recruit NcoA3 (show NCOA3 Antibodies) to the TEAD-YAP (show YAP1 Antibodies) transcriptional complex and potentiate its transcriptional activity.

Cow (Bovine) Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. beta-catenin (show CTNNB1 Antibodies) controls myocardin (show MYOCD Antibodies)-related transcription factor-dependent transcription and emerges as a critical regulator of an array of cytoskeletal genes.

Mouse (Murine) Megakaryoblastic Leukemia (Translocation) 1 (MKL1) interaction partners

  1. Here, the authors show that Rho-dependent MRTF phosphorylation reflects its nuclear accumulation and dissociation from G-actin (show ACTB Antibodies), and identify multiple sites for MRTF phosphorylation, which contribute to transcriptional activation.

  2. BRG1 promotes transcription of endothelial Mrtfa and Mrtfb, which elevates expression of SRF and SRF target genes that establish embryonic capillary integrity.

  3. knockdown of MKL1 induces a significant increase in the transcriptional activity of PPARgamma (show PPARG Antibodies) target genes and MKL1 interacts with PPARg (show PPARG Antibodies), suggesting that SRF and MKL1 independently inhibit brown adipogenesis and that MKL1 exerts its effect mainly by modulating PPARgamma (show PPARG Antibodies) activity

  4. further found that hypericin ameliorates inflammatory response by suppressing MKL1, which is the essential cofactor of p65 (show NFkBP65 Antibodies) during the transcription process. In an Abeta (show APP Antibodies) injection AD mouse model, animals orally administrated hypericin (50 mg/kg) for seven days significantly decreased pro-inflammatory cytokines expression and NO production in hippocampus, meanwhile, hypericin improved oAbeta42-induced learning and memory...

  5. Study demonstrates that WH2 domains activate MRTF-A and contribute to target gene regulation by a competitive mechanism, independently of their role in actin filament formation.

  6. The transcriptional co-activator MRTF-A was activated by sphingosine-1-phosphate as assessed by its nuclear accumulation and induction of a RhoA (show RHOA Antibodies)/MRTF-A luciferase reporter.

  7. MRTF-A regulates liver fibrosis by epigenetically tuning the TGF-beta (show TGFB1 Antibodies) signaling pathway in HSCs

  8. Exploration of the molecular causes of enhanced cardiac hypertrophy revealed significant activation of beta-catenin/GSK-3beta signaling, whereas MAPK and MKL1/serum-response factor pathways were inhibited.

  9. MRTF-A is a critical for epithelial to mesenchymal transition and can be stereoselectively inhibited by CCG-1423.

  10. MKL1 plays a significant role in mediating the fibrotic response to bleomycin injury. Loss of MKL1 attenuated early neutrophil influx, as well as myofibroblast-mediated remodeling.

MKL1 Antigen Profile

Protein Summary

The protein encoded by this gene interacts with the transcription factor myocardin, a key regulator of smooth muscle cell differentiation. The encoded protein is predominantly nuclear and may help transduce signals from the cytoskeleton to the nucleus. This gene is involved in a specific translocation event that creates a fusion of this gene and the RNA-binding motif protein-15 gene. This translocation has been associated with acute megakaryocytic leukemia.

Gene names and symbols associated with MKL1

  • megakaryoblastic leukemia (translocation) 1 (MKL1) antibody
  • megakaryoblastic leukemia 1 protein (mkl1) antibody
  • megakaryoblastic leukemia (translocation) 1 (Mkl1) antibody
  • megakaryoblastic leukemia (translocation) 1 S homeolog (mkl1.S) antibody
  • MKL (megakaryoblastic leukemia)/myocardin-like 1 (Mkl1) antibody
  • AI852829 antibody
  • AMKL antibody
  • AW743281 antibody
  • AW821984 antibody
  • Bsac antibody
  • Mal antibody
  • MKL1 antibody
  • Mrtf-A antibody
  • mrtfa antibody

Protein level used designations for MKL1

megakaryoblastic leukemia 1 protein , MKL/myocardin-like protein 1 , RNA-binding motif protein 15/megakaryoblastic leukemia-1 fusion protein , basic, SAP and coiled-coil domain , megakaryocytic acute leukemia protein , myocardin-related transcription factor A , xMRTF-A , basic SAP and coiled-coil domains , basic SAP coiled-coil transcription activator , megakaryoblastic leukemia (translocation) 1 homolog , megakaryoblastic leukemia 1 protein homolog

GENE ID SPECIES
745765 Pan troglodytes
100358994 Oryctolagus cuniculus
100510767 Anolis carolinensis
418005 Gallus gallus
57591 Homo sapiens
509011 Bos taurus
315151 Rattus norvegicus
398403 Xenopus laevis
223701 Mus musculus
Selected quality suppliers for anti-MKL1 (MKL1) Antibodies
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