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MEOX2 encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. Additionally we are shipping Mesenchyme Homeobox 2 Antibodies (99) and Mesenchyme Homeobox 2 Kits (1) and many more products for this protein.
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3D topography transiently induces concomitant upregulation of IL-1beta and MAPK ERK1/2 through nuclear factor-kappaB-dependent signaling pathway.
MEOX2 participates in chemoresistance irrespective of high CNV, but it is significantly dependent upon H3K27me3 enrichment probably associated with aggressiveness and chemotherapy failure in NSCLC patients
Genetic variation in MEOX2, but not TCF15 (show TCF15 Proteins), is a strong predictor of CHD (show CHDH Proteins). Further experimental studies should elucidate the underlying molecular mechanisms.
Microarray profiling on freshly isolated ECs had a genetic signature for microvascular heart ECs and identified Meox2/Tcf15 (show TCF15 Proteins) heterodimers as novel transcriptional determinants. This signature was similar in skeletal muscle and adipose tissue endothelium.
downregulated expression of GAX is an independent prognostic factor and is correlated with poor survival in hepatocellular carcinoma patients
MEOX1 (show MEOX1 Proteins) and MEOX2 activate p16(INK4a) in a DNA binding dependent manner, whereas they induce p21(CIP1/WAF1 (show CDKN1A Proteins)) in a DNA binding independent manner.
Report of an interaction between a homeobox protein and IkappaBbeta (show NFKBIB Proteins) in endothelial cells and suggest that MEOX2 modulates the activity of the RelA (show NFkBP65 Proteins) complex through direct interaction with its components.
homeobox protein Gax is expressed in vascular endothelium and strongly inhibits endothelial cell activation in response to growth factors and tube formation in vitro
The link of MEOX2 to neurovascular dysfunction in Alzheimer disease provides new mechanistic and therapeutic insights into this illness.
MEOX2 binding to RNF10 (show RNF10 Proteins) protein, human, was characterized.
The miRNA family miR (show MLXIP Proteins)-130/301/721 enhances induced pluripotent stem cells generation via repression of Meox2.
Results demonstrate that Meox1 (show MEOX1 Proteins) and Meox2 genes function together and upstream of several genetic hierarchies that are required for the development of somites.
reduction of Meox-2 function is associated with susceptibility to cleft palate
Meox2 binding to RNF10 (show RNF10 Proteins) protein, human, was characterized.
ectopic Meox2 suppressed epithelial cell proliferation in cooperation with TGF-beta1 (show TGFB1 Proteins), and mediated induction of the cell cycle inhibitor gene p21.
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.
mesenchyme homeobox 2
, growth arrest-specific homeo box
, mesenchyme homeobox 2 a
, homeobox protein MOX-2
, mesenchyme homeo box 2 (growth arrest-specific homeo box)
, growth arrest-specific homeobox
, growth arrest homeobox transcription factor GAX
, homeobox protein MOX-2 b
, mesenchyme homeobox 2 b