anti-Mesoderm Development Candidate 2 (MESDC2) Antibodies

Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Additionally we are shipping MESDC2 Proteins (11) and MESDC2 Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MESDC2 23184 Q14696
MESDC2 67943 Q9ERE7
MESDC2 308796 Q5U2R7
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Top anti-MESDC2 Antibodies at antibodies-online.com

Showing 10 out of 39 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, IHC (p), WB MESDC2 Antibody (C-term) (ABIN655585) western blot analysis in Hela,293,HepG2 cell line lysates (35 µg/lane). This demonstrates the MESDC2 antibody detected the MESDC2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IF, WB   0.4 mL Log in to see 12 to 15 Days
$375.38
Details
Human Rabbit Un-conjugated IHC (p), IP, WB Human Pancreas: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Placenta: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 7 to 9 Days
$676.50
Details
Human Rabbit Un-conjugated ELISA   100 μg Log in to see 20 to 21 Days
$163.90
Details
Human Rabbit Un-conjugated IP, WB 100 μg Log in to see 20 to 21 Days
$218.90
Details
Human Rabbit Un-conjugated IP, ELISA, WB 100 μg Log in to see 20 to 21 Days
$273.90
Details
Human Rabbit Un-conjugated IF, IHC, WB   100 μL Log in to see 16 Days
$323.13
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB Immunohistochemistry-Paraffin: MESDC2 Antibody [NBP2-30007] - Immunohistochemistry analysis in formalin fixed and paraffin embedded human stomach tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. Western Blot: MESDC2 Antibody [NBP2-30007] - Western blot analysis of lysates from K562, mouse NIH/3T3 cell line (from left to right), using (C-term) (NBP2-30007). AP11638b was diluted at 1:1000 at each lane. A goat anti-rabbit(HRP) at 1:5000 dilution was used as the secondary antibody. Lysates at 35ug per lane. 0.4 mL Log in to see 10 to 13 Days
$408.19
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: MESDC2 Antibody [NBP1-88555] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp Immunohistochemistry-Paraffin: MESDC2 Antibody [NBP1-88555] - Staining of human duodenum shows moderate cytoplasmic and nuclear positivity in glandular cells. 0.1 mL Log in to see 10 to 13 Days
$439.69
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 2 to 3 Days
$289.00
Details

MESDC2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Human , ,
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Mouse (Murine)
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Rat (Rattus)

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More Antibodies against MESDC2 Interaction Partners

Human Mesoderm Development Candidate 2 (MESDC2) interaction partners

  1. Mesd C-terminal region constitutes the major LRP5 (show LRP5 Antibodies)/6-binding domain, and that Mesd protein and its C-terminal region peptide have a potential therapeutic value in cancer

  2. Results indicate that Mesd is a universal inhibitor of Wnt (show WNT2 Antibodies)/LRP (show RPSA Antibodies) signaling on the cell surface.

  3. Results provide evidence that MESD functions as a general LRP (show RPSA Antibodies) chaperone and suggest that the Mesd phenotype results from both signaling and endocytic defects resulting from misfolding of multiple LRP (show RPSA Antibodies) receptors.

  4. Two structural and functional domains of MESD required for proper folding and trafficking of LRP5/LRP6 (show LRP5 Antibodies).

  5. a high bone mass mutant LRP5 (show LRP5 Antibodies)(G171V), has subtly reduced Dkk1 (show DKK1 Antibodies) binding, and, in contrast to LRP5 (show LRP5 Antibodies), no enhancement of binding with MesD

  6. as a result of (12;15)(q13;q25)translocation, the SUMO/Sentrin-specific protease 1 (show SENP1 Antibodies) gene (SENP1 (show SENP1 Antibodies)) on chromosome 12 and the embryonic polarity-related mesoderm development gene (MESDC2) on chromosome 15 are disrupted and fused

  7. Mesd and LRP6 (show LRP6 Antibodies) modulate Wnt (show WNT2 Antibodies) signaling.

Mouse (Murine) Mesoderm Development Candidate 2 (MESDC2) interaction partners

  1. Mescd2 binds to Lrp4 (show CORIN Antibodies) and regulates Lrp4 (show CORIN Antibodies) surface expression in myotubes.

  2. Mesd C-terminal region constitutes the major LRP5 (show LRP5 Antibodies)/6-binding domain, and that Mesd protein and its C-terminal region peptide have a potential therapeutic value in cancer

  3. The region 45-184 of MESD is essential and sufficient to act as a molecular chaperone (show HSP90AA1 Antibodies) for the low-density lipoprotein receptor (LDLR (show LDLR Antibodies)) family.

  4. We show that MESD contains a central folded domain flanked by unstructured regions required to facilitate maturation of LRP6 (show LRP6 Antibodies). Enforced expression of human MESD promotes the secretion of soluble minireceptors derived from LRP6 (show LRP6 Antibodies).

  5. Functional analyses of the Lrp6 (show LRP6 Antibodies) rs mutant showed decreased targeting to plasma membrane because of reduced interaction with Mesoderm development (Mesd), a chaperone for Lrp6 (show LRP6 Antibodies), leading to impaired Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling

  6. Secondary structure prediction using chemical shift data indicates that MESD(12-155) contains four a-helices and five b-sheets.

  7. Mesd not only blocks binding of Dickkopf (show DKK1 Antibodies) (DKK)-1 (show DKK1 Antibodies) and sclerostin (show SOST Antibodies) proteins to low-density lipoprotein receptor (show LDLR Antibodies)-related protein (LRP (show LRP1 Antibodies))5 (show LRP5 Antibodies) and LRP6 (show LRP6 Antibodies) but also inhibits Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling in LRP5 (show LRP5 Antibodies)- or LRP6 (show LRP6 Antibodies)- expressing cancer cells.

  8. Together our results show that in addition to serving as a folding chaperone, Mesd can function as a receptor antagonist by inhibiting ligand binding to mature LRP6 (show LRP6 Antibodies).

MESDC2 Antigen Profile

Protein Summary

Chaperone specifically assisting the folding of beta- propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway, since some LDLRs are coreceptors for the canonical Wnt pathway (By similarity).

Gene names and symbols associated with MESDC2

  • mesoderm development candidate 2 (MESDC2) antibody
  • mesoderm development candidate 2 (mesdc2) antibody
  • mesoderm development candidate 2 (CpipJ_CPIJ010816) antibody
  • mesoderm development candidate 2 (Tsp_04045) antibody
  • Mesoderm development candidate 2 (LOC100157638) antibody
  • KIAA1199 (KIAA1199) antibody
  • mesoderm development candidate 2 (Mesdc2) antibody
  • 2210015O11Rik antibody
  • AW537813 antibody
  • BOCA antibody
  • mesd antibody
  • MESDC2 antibody
  • MGC115616 antibody
  • mKIAA0081 antibody
  • msd antibody
  • zgc:158636 antibody

Protein level used designations for MESDC2

mesoderm development candidate 2 , Mesoderm development candidate 2 , LDLR chaperone MESD , mesoderm development protein , renal carcinoma antigen NY-REN-61 , mesoderm development candiate 2

GENE ID SPECIES
453586 Pan troglodytes
488765 Canis lupus familiaris
712993 Macaca mulatta
734603 Xenopus laevis
6043369 Culex quinquefasciatus
10904464 Trichinella spiralis
100135217 Xenopus (Silurana) tropicalis
100157638 Sus scrofa
100174652 Pongo abelii
23184 Homo sapiens
67943 Mus musculus
308796 Rattus norvegicus
514610 Bos taurus
415475 Gallus gallus
791222 Danio rerio
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