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MACC1 is a key regulator of the hepatocyte growth factor (HGF\; MIM 142409)-HGF receptor (HGFR, or MET\; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Additionally we are shipping MACC1 Antibodies (40) and MACC1 Kits (9) and many more products for this protein.
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MACC1 gene (metastasis-associated in colon cancer 1) is upregulated in cancer stem cells both resistant and sensitive to chemotherapy
MACC1 overexpression is associated with gastric cancer.
High MACC1 expression is associated with colorectal cancer.
Downregulation of MACC1 upregulates E-cadherin (show CDH1 Proteins), N-cadherin (show CDH2 Proteins) and Vimentin (show VIM Proteins) in melanoma cell lines.
MACC1 is essential for acetylcholine-induced gastric cancer cell invasion/migration and epithelial-mesenchymal transition
Study demonstrated that suppression of MACC1 improves the chemosensitivity of cisplatin in epithelial ovarian cancer cells probably through regulation of the ERK1/2 signaling pathway and P-gp (show ABCB4 Proteins) and its downstream apoptotic proteins.
MACC1 was a specific target gene of miR (show MLXIP Proteins)-338-3p, which regulates malignant biological behaviors of glioma cells partly through directly silencing MACC1 expression.
This study suggests that MACC1 is an independent prognostic factor in gastric adenocarcinoma and that the prognostic impact of MACC1 may be associated with MACC1 partners other than MET.
Metastasis-associated in colon cancer-1 may have an important role in tumour development in adenoid cystic carcinoma. Metastasis-associated in colon cancer-1 is a potential biomarker for adenoid cystic carcinoma.
downregulation of MACC1 expression could enhance cisplatin sensitivity and decrease drug resistance in SKOV- 3/DDP (show TIMM8A Proteins) cells.
Data suggest a critical role for MACC1 in lymphatic dissemination of GC, providing evidence that MACC1 upregulated VEGF-C/VEGF-D secretion to promote lymphangiogenesis via c-Met signaling.
HGF, MACC1 and C-met genes involve into malignant cervical tumors occurrence, development and prognosis, and might become potential molecular target therapy site of cervical cancer
MACC1 has a role in colorectal cancer and can be used for imaging in xenografts
MACC1 will be useful for the identification of poor prognosis subjects with colorectal cancer and is a promising new target for intervention in metastasis formation.
MACC1 is a key regulator of the hepatocyte growth factor (HGF\; MIM 142409)-HGF receptor (HGFR, or MET\; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009
SH3 domain-containing protein 7a5
, metastasis-associated in colon cancer protein 1
, putative binding protein 7a5