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Metastasis Associated in Colon Cancer 1 Proteins (MACC1)

MACC1 is a key regulator of the hepatocyte growth factor (HGF\; MIM 142409)-HGF receptor (HGFR, or MET\; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Additionally we are shipping MACC1 Antibodies (40) and MACC1 Kits (9) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MACC1 346389 Q6ZN28
Mouse MACC1 MACC1 238455  
Rat MACC1 MACC1 314539  
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Top MACC1 Proteins at antibodies-online.com

Showing 4 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 69 Days
$11,073.30
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$862.40
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 16 Days
$900.63
Details

MACC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,

More Proteins for Metastasis Associated in Colon Cancer 1 (MACC1) Interaction Partners

Human Metastasis Associated in Colon Cancer 1 (MACC1) interaction partners

  1. MACC1 gene (metastasis-associated in colon cancer 1) is upregulated in cancer stem cells both resistant and sensitive to chemotherapy

  2. MACC1 overexpression is associated with gastric cancer.

  3. High MACC1 expression is associated with colorectal cancer.

  4. Downregulation of MACC1 upregulates E-cadherin (show CDH1 Proteins), N-cadherin (show CDH2 Proteins) and Vimentin (show VIM Proteins) in melanoma cell lines.

  5. MACC1 is essential for acetylcholine-induced gastric cancer cell invasion/migration and epithelial-mesenchymal transition

  6. Study demonstrated that suppression of MACC1 improves the chemosensitivity of cisplatin in epithelial ovarian cancer cells probably through regulation of the ERK1/2 signaling pathway and P-gp (show ABCB4 Proteins) and its downstream apoptotic proteins.

  7. MACC1 was a specific target gene of miR (show MLXIP Proteins)-338-3p, which regulates malignant biological behaviors of glioma cells partly through directly silencing MACC1 expression.

  8. This study suggests that MACC1 is an independent prognostic factor in gastric adenocarcinoma and that the prognostic impact of MACC1 may be associated with MACC1 partners other than MET.

  9. Metastasis-associated in colon cancer-1 may have an important role in tumour development in adenoid cystic carcinoma. Metastasis-associated in colon cancer-1 is a potential biomarker for adenoid cystic carcinoma.

  10. downregulation of MACC1 expression could enhance cisplatin sensitivity and decrease drug resistance in SKOV- 3/DDP (show TIMM8A Proteins) cells.

Mouse (Murine) Metastasis Associated in Colon Cancer 1 (MACC1) interaction partners

  1. Data suggest a critical role for MACC1 in lymphatic dissemination of GC, providing evidence that MACC1 upregulated VEGF-C/VEGF-D secretion to promote lymphangiogenesis via c-Met signaling.

  2. HGF, MACC1 and C-met genes involve into malignant cervical tumors occurrence, development and prognosis, and might become potential molecular target therapy site of cervical cancer

  3. MACC1 has a role in colorectal cancer and can be used for imaging in xenografts

  4. MACC1 will be useful for the identification of poor prognosis subjects with colorectal cancer and is a promising new target for intervention in metastasis formation.

MACC1 Protein Profile

Protein Summary

MACC1 is a key regulator of the hepatocyte growth factor (HGF\; MIM 142409)-HGF receptor (HGFR, or MET\; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009

Gene names and symbols associated with MACC1

  • metastasis associated in colon cancer 1 (MACC1)
  • metastasis associated in colon cancer 1 (Macc1)
  • 7a5 protein
  • 4732474O15Rik protein
  • Gm267 protein
  • RGD1309838 protein
  • SH3BP4L protein

Protein level used designations for MACC1

SH3 domain-containing protein 7a5 , metastasis-associated in colon cancer protein 1 , putative binding protein 7a5

GENE ID SPECIES
346389 Homo sapiens
238455 Mus musculus
314539 Rattus norvegicus
521867 Bos taurus
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