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MACC1 is a key regulator of the hepatocyte growth factor (HGF\; MIM 142409)-HGF receptor (HGFR, or MET\; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Additionally we are shipping MACC1 Antibodies (40) and MACC1 Kits (10) and many more products for this protein.
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Metastasis-associated in colon cancer 1 is expressed at early stages of colorectal oncogenesis within the affected colonic tissue in colorectal cancer patient cohort.
MACC1 is a key driver and prognostic biomarker for cancer progression and metastasis in a large variety of solid tumor types, particularly colorectal cancer (CRC (show CALR Proteins)). Data suggest that some small molecules with antineoplastic activity inhibit MACC1 transcription in CRC (show CALR Proteins) and prevent liver metastasis in CRC (show CALR Proteins); lovastatin and rottlerin are the antineoplastic agents used here.
MACC1 regulates Fas (show FAS Proteins) mediated apoptosis through STAT1 (show STAT1 Proteins)/3 - Mcl-1 (show MCL1 Proteins) signaling in solid cancers.
High expression of MACC1 is associated with non-small cell lung cancer.
MACC1 down-regulation suppresses endometrial carcinoma cell proliferation.
SPON2 (show SPON2 Proteins) is a transcriptional target of the metastasis gene MACC1. SPON2 (show SPON2 Proteins) induces cell motility in vitro and CRC (show CALR Proteins) metastasis in mice. In patients, SPON2 (show SPON2 Proteins) serves as prognostic indicator for CRC (show CALR Proteins) metastasis and survival, and might represent a promising target for therapeutic approaches.
High MACC1 expression is associated with Angiogenesis and recurrence in Gastric Cancer.
Elevated Orai1 and STIM1 (show STIM1 Proteins) expressions upregulate MACC1 expression to promote tumor cell proliferation, metabolism, migration, and invasion in human gastric cancer.
Data show that metastasis-associated in colon cancer-1 (MACC1) and monocarboxylate transporter 1 (MCT1) are highly expressed in gastric cancer indicating poor prognosis.
A novel role of MACC1 in gastric cancer cell lipogenesis.MACC1 and FASN (show FASN Proteins) are positively correlated and responsible for the poor prognoses in gastric cancer patients.
Data suggest a critical role for MACC1 in lymphatic dissemination of GC, providing evidence that MACC1 upregulated VEGF-C/VEGF-D secretion to promote lymphangiogenesis via c-Met signaling.
HGF, MACC1 and C-met genes involve into malignant cervical tumors occurrence, development and prognosis, and might become potential molecular target therapy site of cervical cancer
MACC1 has a role in colorectal cancer and can be used for imaging in xenografts
MACC1 will be useful for the identification of poor prognosis subjects with colorectal cancer and is a promising new target for intervention in metastasis formation.
MACC1 is a key regulator of the hepatocyte growth factor (HGF\; MIM 142409)-HGF receptor (HGFR, or MET\; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009
SH3 domain-containing protein 7a5
, metastasis-associated in colon cancer protein 1
, putative binding protein 7a5