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MACC1 Products

(Metastasis Associated in Colon Cancer 1 (MACC1))
MACC1 is a key regulator of the hepatocyte growth factor (HGF\; MIM 142409)-HGF receptor (HGFR, or MET\; MIM 164860) pathway, which is involved in cellular growth, epithelial-mesenchymal transition, angiogenesis, cell motility, invasiveness, and metastasis. Expression of MACC1 in colon cancer (MIM 114500) specimens is an independent prognostic indicator for metastasis formation and metastasis-free survival (Stein et al., 2009 [PubMed 19098908]).[supplied by OMIM, Mar 2009].

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Featured MACC1 Categories

MACC1 Antibodies

High quality antibodies with extensive validation data.

MACC1 ELISA Kits

Reliable ELISA kits for a wide range of species.

MACC1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended MACC1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Rat
Application ELISA, IF (cc), IF (p), IHC (fro), IHC (p), WB
Validations
  • (6)
  • (5)
Cat. No. ABIN706526
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application ELISA, IF, IHC, WB
Validations
  • (3)
Cat. No. ABIN7159558
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application ICC, IHC, WB
Validations
  • (3)
Cat. No. ABIN1859735
Quantity 100 μL
Datasheet Datasheet

Recommended MACC1 ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (2)
  • (1)
Cat. No. ABIN6957784
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6975740
Quantity 96 tests
Datasheet Datasheet

Recommended MACC1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3093653
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
Cat. No. ABIN3010685
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2725110
Quantity 20 μg
Datasheet Datasheet

Latest Publications for our MACC1 products

Shi, Song, Wang, Zhang, Zheng: "MACC‑1 antibody target therapy suppresses growth and migration of non‑small cell lung cancer." in: Molecular medicine reports, Vol. 16, Issue 5, pp. 7329-7336, (2017) (PubMed).

Montorsi, Guizzetti, Alecci, Caporali, Martello, Atene, Parenti, Pizzini, Zanovello, Bortoluzzi, Ferrari, Grande, Zanocco-Marani: "Loss of zfp36 expression in colorectal cancer correlates to wnt/ ß-catenin activity and enhances epithelial-to-mesenchymal transition through upregulation of zeb1, sox9 and macc1." in: Oncotarget, Vol. 7, Issue 37, pp. 59144-59157, (2016) (PubMed).

Liu, Pan, Guo, Wu, Guo, Peng, Wu, Zuo: "A new mechanism of trastuzumab resistance in gastric cancer: MACC1 promotes the Warburg effect via activation of the PI3K/AKT signaling pathway." in: Journal of hematology & oncology, Vol. 9, Issue 1, pp. 76, (2016) (PubMed).

Sun, Li, Dai, Tan, Zhao, Li, Wang: "Silence of MACC1 expression by RNA interference inhibits proliferation, invasion and metastasis, and promotes apoptosis in U251 human malignant glioma cells." in: Molecular medicine reports, Vol. 12, Issue 3, pp. 3423-31, (2015) (PubMed).

Ge, Meng, Zhou, Zhang, Ding: "Positive MACC1 expression correlates with invasive behaviors and postoperative liver metastasis in colon cancer." in: International journal of clinical and experimental medicine, Vol. 8, Issue 1, pp. 1094-100, (2015) (PubMed).

Koelzer, Herrmann, Zlobec, Karamitopoulou, Lugli, Stein: "Heterogeneity analysis of Metastasis Associated in Colon Cancer 1 (MACC1) for survival prognosis of colorectal cancer patients: a retrospective cohort study." in: BMC cancer, Vol. 15, pp. 160, (2015) (PubMed).

Li, Zhang, Zhao, Shi, Yao, Zhang, Guo, Liu: "Overexpression of MACC1 and the association with hepatocyte growth factor/c-Met in epithelial ovarian cancer." in: Oncology letters, Vol. 9, Issue 5, pp. 1989-1996, (2015) (PubMed).

Kuo, Wu, Chang, Huang, Lin, Yan, Sheu, Lu, Chang, Lai, Wang: "Low SOX17 expression is a prognostic factor and drives transcriptional dysregulation and esophageal cancer progression." in: International journal of cancer, Vol. 135, Issue 3, pp. 563-73, (2014) (PubMed).

Hagemann, Fuchs, Monoranu, Herrmann, Smith, Hohmann, Grabiec, Kessler, Dehghani, Löhr, Ernestus, Vince, Stein: "Impact of MACC1 on human malignant glioma progression and patients' unfavorable prognosis." in: Neuro-oncology, Vol. 15, Issue 12, pp. 1696-709, (2013) (PubMed).

Guo, Yang, Yao, Zhang, Da, Duan: "Expression of MACC1 and c-Met in human gastric cancer and its clinical significance." in: Cancer cell international, Vol. 13, Issue 1, pp. 121, (2013) (PubMed).

Synonyms and alternative names related to MACC1

MACC1, MET transcriptional regulator (MACC1), metastasis associated in colon cancer 1 (Macc1), MACC1, MET transcriptional regulator (Macc1), 7A5, 7a5, 4732474O15Rik, Gm267, RGD1309838, SH3BP4L

Protein level used designations for MACC1

  • SH3 domain-containing protein 7a5
  • metastasis-associated in colon cancer protein 1
  • putative binding protein 7a5
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