Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase Proteins (MTHFD2)

MTHFD2 encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. Additionally we are shipping Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase Antibodies (47) and Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
MTHFD2 17768 P18155
MTHFD2 10797 P13995
Rat MTHFD2 MTHFD2 680308  
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Top Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase Proteins at antibodies-online.com

Showing 8 out of 8 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 0.05 mg Log in to see 2 to 3 Days
$378.13
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HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
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HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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HOST_Escherichia coli (E. coli) Human His tag   100 μg Log in to see 2 to 3 Days
$418.88
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HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
$229.85
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HOST_Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,843.50
Details

MTHFD2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase (MTHFD2) Interaction Partners

Mouse (Murine) Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase (MTHFD2) interaction partners

  1. Data suggest that Ad4BP (show NR5A1 Proteins) plays role in regulation of intracellular NADPH (show FDXR Proteins) concentration via transcription of Me1 (show ME1 Proteins) and Mthfd2 genes in adrenocortical cells. (Ad4BP (show NR5A1 Proteins) = nuclear receptor subfamily 5 group A member 1 (show NR5A1 Proteins); Me1 (show ME1 Proteins) = malic enzyme 1 (show ME1 Proteins); Mthfd2 = bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase)

  2. A mutation in methylenetetrahydrofolate reductase (MTHFR (show MTHFR Proteins)) gene, may contribute to the risk of both arterial and deep-vein thrombosis in patients with nephrotic syndrome.

Human Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase (MTHFD2) interaction partners

  1. crystal structure of MTHFD2 in complex with a substrate-based inhibitor and the enzyme cofactors NAD(+) and inorganic phosphate.

  2. Mechanistically, MYC (show MYC Proteins) regulates the expression of MTHFD2, and MTHFD2 knockdown suppresses the TCA cycle.

  3. siRNA-mediated silencing of MTHFD2 inhibited migration, invasion and epithelial-mesenchymal transition progression in hepatocellular carcinoma (HCC (show FAM126A Proteins)) cell lines, but no obvious effects on cell proliferation, apoptosis or cell cycle distribution were detected. MTHFD2 is overexpressed in HCC (show FAM126A Proteins), and is associated with poor prognosis and cellular features connected to metastatic disease.

  4. These findings suggest a previously unknown role for MTHFD2 in cancer cell proliferation, adding to its known function in mitochondrial folate metabolism.

  5. The highest scoring pathway is mitochondrial one-carbon metabolism and is centred on MTHFD2.

  6. Data indicate that methylenetetrahydrofolate dehydrogenase (NADP + -dependent) 2 (MTHFD2)was differentially expressed in breast cancer tissue, suggesting as a prognostic factor and a potential therapeutic target for future breast cancer treatments.

  7. Data indicate that the reduced vimentin (show VIM Proteins) expression in response to EPHB4 (show EPHB4 Proteins), WIPF2 and MTHFD2 silencing was observed at mRNA and protein levels.

Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase (MTHFD2) Protein Profile

Protein Summary

This gene encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in two different transcripts, one protein-coding and the other not protein-coding. This gene has a pseudogene on chromosome 7.

Gene names and symbols associated with MTHFD2

  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (mthfd2)
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (MTHFD2)
  • methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase (mthfd2)
  • methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase (Mthfd2)
  • methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase (Mthfd2)
  • AW558851 protein
  • NMDMC protein
  • wu:fb38b11 protein
  • wu:fe12e11 protein
  • zgc:91891 protein

Protein level used designations for MTHFD2

bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial , methylene tetrahydrofolate dehydrogenase 2 , methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase , methylenetetrahydrofolate dehydrogenase 2 , NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase , methylene tetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase , methylenetetrahydrofolate dehydrogenase (NAD+ dependent), methenyltetrahydrofolate cyclohydrolase

GENE ID SPECIES
432317 Xenopus laevis
459331 Pan troglodytes
100053990 Equus caballus
100170462 Xenopus (Silurana) tropicalis
100584729 Nomascus leucogenys
446641 Xenopus laevis
17768 Mus musculus
426126 Gallus gallus
10797 Homo sapiens
483107 Canis lupus familiaris
517539 Bos taurus
680308 Rattus norvegicus
100004977 Danio rerio
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