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anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) Antibodies

The protein encoded by MAP4K4 is a member of the serine/threonine protein kinase family. Additionally we are shipping MAP4K4 Proteins (4) and MAP4K4 Kits (1) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MAP4K4 9448 O95819
MAP4K4 26921 P97820
MAP4K4 301363  
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Top anti-MAP4K4 Antibodies at antibodies-online.com

Showing 10 out of 149 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-MAP4K4 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Human Small Intestine 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EIA 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated EIA, WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ELISA, WB Figure 1: Western blot analysis using MAP4K4 mouse mAb against truncated Trx-MAP4K4 recombinant protein (1), MBP-MAP4K4 (aa300-400) recombinant protein (2) and MAP4K4 (aa194-436) -hIgGFc transfected CH0-K1 cell lysate (3) . 100 μL Log in to see 3 to 4 Days
$393.80
Details
Human Rabbit Un-conjugated IHC (p) Flow cytometric analysis of rabbit anti-MAP4K4 (SP177) antibody in HEPG2 (green) compare to negative control of rabbit IgG (blue). 7 mL Log in to see 21 to 31 Days
$367.00
Details
Human Rabbit Un-conjugated FACS, IHC (p) 1 mL Log in to see 6 to 8 Days
$797.50
Details
Human Mouse Un-conjugated IHC (p), ELISA, WB MAP4K4 monoclonal antibody (M07), clone 4A5 Western Blot analysis of MAP4K4 expression in K-562 . Immunoperoxidase of monoclonal antibody to MAP4K4 on formalin-fixed paraffin-embedded human breast cancer. [antibody concentration 3 ug/ml] 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated WB   100 μL Log in to see 10 to 11 Days
$464.29
Details
Human Rabbit Un-conjugated WB Mouse Map4k4 Antibody (Center) (ABIN658380) western blot analysis in mouse brain tissue lysates (35 µg/lane). This demonstrates the Map4k4 antibody detected the Map4k4 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details

MAP4K4 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-MAP4K4 Antibodies

  1. Human Monoclonal MAP4K4 Primary Antibody for WB - ABIN2869325 : Becker, Huynh-Do, Holland, Pawson, Daniel, Skolnik: Nck-interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation. in Molecular and cellular biology 2000 (PubMed)
    Show all 3 references for ABIN2869325

  2. Human Polyclonal MAP4K4 Primary Antibody for EIA - ABIN358379 : Wright, Wang, Manning, LaMere, Le, Zhu, Khatry, Flanagan, Buckley, Whyte, Howlett, Bischoff, Lipson, Jallal: The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. in Molecular and cellular biology 2003 (PubMed)
    Show all 3 references for ABIN358379

  3. Human Monoclonal MAP4K4 Primary Antibody for ELISA, WB - ABIN969274 : Poinat, De Arcangelis, Sookhareea, Zhu, Hedgecock, Labouesse, Georges-Labouesse: A conserved interaction between beta1 integrin/PAT-3 and Nck-interacting kinase/MIG-15 that mediates commissural axon navigation in C. elegans. in Current biology : CB 2002 (PubMed)
    Show all 3 references for ABIN969274

  4. Human Polyclonal MAP4K4 Primary Antibody for EIA - ABIN358366 : Yao, Zhou, Wang, Brown, Diener, Gan, Tan: A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway. in The Journal of biological chemistry 1999 (PubMed)
    Show all 3 references for ABIN358366

  5. Human Monoclonal MAP4K4 Primary Antibody for IHC (p), ELISA - ABIN564078 : Ma, Baumgartner: Filopodia and membrane blebs drive efficient matrix invasion of macrophages transformed by the intracellular parasite Theileria annulata. in PLoS ONE 2013 (PubMed)
    Show all 2 references for ABIN564078

  6. Human Polyclonal MAP4K4 Primary Antibody for EIA, WB - ABIN360426 : Austin, Rune, Bouzakri, Zierath, Krook: siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle. in Diabetes 2008 (PubMed)
    Show all 2 references for ABIN360426

  7. Chicken Polyclonal MAP4K4 Primary Antibody for IHC, WB - ABIN2783612 : Bouzakri, Zierath: MAP4K4 gene silencing in human skeletal muscle prevents tumor necrosis factor-alpha-induced insulin resistance. in The Journal of biological chemistry 2007 (PubMed)

More Antibodies against MAP4K4 Interaction Partners

Human Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) interaction partners

  1. miR (show MLXIP Antibodies)-194 regulated the progression of hepatocellular carcinoma through directly inhibiting the expression of MAP4K4

  2. The results of the present study suggested that inhibition of MAP4K4 may be a therapeutic strategy for gastric cancer.

  3. loss of MAP4K4 function suppressed pathological angiogenesis in disease models, identifying MAP4K4 as a potential therapeutic target

  4. that MAP4K4, a known mediator of inflammation, is involved in KS aetiology by regulating KSHV lytic reactivation

  5. results reveal a key target of SOX2 (show SOX2 Antibodies) expression and highlight the unexpected context-dependent role for MAP4K4, a pluripotent activator of several mitogen-activated protein kinase (show MAPK1 Antibodies) pathways, in regulating tumor cell survival.

  6. TRAF1.NIK is a central complex linking canonical and non-canonical pathways by disrupting the TRAF2-cIAP2 ubiquitin ligase complex

  7. Common polymorphisms in MAP4K4 are associated with insulin (show INS Antibodies) resistance and beta-cell dysfunction, possibly via this gene's role in inflammatory signaling.

  8. Elevated MAP4K4 expression is closely associated with lung adenocarcinoma progression with independent prognostic value in predicting overall survival for patients with lung adenocarcinoma.

  9. MAP4K4 overexpression is an independent predictor of poor prognosis of Hepatocellular Carcinoma patients, and inhibition of its expression might be of therapeutic significance

  10. Data show that down-regulation of hepatocyte progenitor kinase-like kinase (HGK) can obviously inhibit the migration and invasion of HepG2 cells in vitro, and suggest that HGK may be a new therapeutic target for treatment of hepatocellular carcinoma.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 (MAP4K4) interaction partners

  1. These results reveal that MAP4K4 is a key signalling node that promotes immune cell recruitment in atherosclerosis.

  2. Mice with Map4k4 deleted in Myf5 (show MYF5 Antibodies)-positive tissues, including all skeletal muscles tested, were protected from obesity-induced glucose intolerance and insulin (show INS Antibodies) resistance.

  3. HGK/MAP4K4 deficiency has a role in inducing TRAF2 (show TRAF2 Antibodies) stabilization and Th17 differentiation leading to insulin (show INS Antibodies) resistance

  4. microtubules can deliver MAP4K4 toward focal adhesions through ending binding 2

  5. MAP4K4 is essential for CD4 (show CD4 Antibodies)+ T cell proliferation and activation in vitro through suppressing PKC-theta (show PRKCQ Antibodies) activation.

  6. Map4k4 inhibits adipose lipogenesis by suppression of Srebp-1 (show SREBF1 Antibodies) in an AMPK (show PRKAA1 Antibodies)- and mTOR (show FRAP1 Antibodies)-dependent but JNK (show MAPK8 Antibodies)-independent mechanism.

  7. Expression of a Map4k4 kinase-inactive mutant enhances myotube formation, suggesting that the kinase activity of Map4k4 is essential for its inhibition of muscle differentiation.

  8. MicroRNA-30d induces insulin (show INS Antibodies) transcription factor MafA (show MAFA Antibodies) and insulin (show INS Antibodies) production by targeting mitogen-activated protein 4 kinase 4 (MAP4K4) in pancreatic beta-cells.

  9. These findings suggest that scorpion venom induces insulin (show INS Antibodies) resistance by mechanisms involving TNF-alpha (show TNF Antibodies)-dependent Map4k4 kinase activation in the adipose tissue.

  10. These data together with previous reports on extramedullary hemopoiesis in RelB (show RELB Antibodies)-deficient mice suggest that NIK-RelB (show RELB Antibodies) signaling may be involved in the suppression of extramedullary hemopoiesis in adult mice.

MAP4K4 Antigen Profile

Protein Summary

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with MAP4K4

  • mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) antibody
  • mitogen-activated protein kinase kinase kinase kinase 4 (Map4k4) antibody
  • 9430080K19Rik antibody
  • AU043147 antibody
  • AU045934 antibody
  • AW046177 antibody
  • FLH21957 antibody
  • HGK antibody
  • MEKKK4 antibody
  • Nik antibody

Protein level used designations for MAP4K4

HPK/GCK-like kinase HGK , MAPK/ERK kinase kinase kinase 4 , MEK kinase kinase 4 , Ste20 group protein kinase HGK , hepatocyte progenitor kinase-like/germinal center kinase-like kinase , nck-interacting kinase , MEKKK 4 , NCK interacting kinase , mitogen activated protein kinase kinase kinase kinase 4

GENE ID SPECIES
9448 Homo sapiens
26921 Mus musculus
418714 Gallus gallus
100516547 Sus scrofa
509109 Bos taurus
301363 Rattus norvegicus
481331 Canis lupus familiaris
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