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Involved in pre-mRNA alternative splicing regulation. Additionally we are shipping MBNL1 Proteins (10) and many more products for this protein.
Showing 10 out of 72 products:
Human Polyclonal MBNL1 Primary Antibody for WB - ABIN1881533
Sen, Talukdar, Liu, Tam, Reddy, Webster: Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer. in The Journal of biological chemistry 2010
Show all 5 references for ABIN1881533
Dog (Canine) Polyclonal MBNL1 Primary Antibody for WB - ABIN2776698
Adereth, Dammai, Kose, Li, Hsu: RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1. in Nature cell biology 2005
Show all 3 references for ABIN2776698
Human Polyclonal MBNL1 Primary Antibody for ELISA, WB - ABIN334433
Warf, Berglund: MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin T. in RNA (New York, N.Y.) 2007
Human Monoclonal MBNL1 Primary Antibody for IF, IHC (p) - ABIN561753
Rehman, Gladman, Periasamy, Sun, Mahadevan: Development of an AP-FRET based analysis for characterizing RNA-protein interactions in myotonic dystrophy (DM1). in PLoS ONE 2014
Depletion of Mbnl1 and/or Mbnl2 (show MBNL2 Antibodies) reduced localization of hundreds of transcripts, implicating Mbnls in localization of mRNAs to neurites
Sense DMPK (show DMPK Antibodies) RNA foci clearly co-localize with MBNL1 and MBNL2 (show MBNL2 Antibodies) proteins and accumulate in myotonic dystrophy 1 tissues during development.
MBNL1 overexpression promotes transformation of fibroblasts into myofibroblasts.
These data indicate that MBNL1 plays a conserved role in negatively regulating TGFbeta (show TGFB1 Antibodies) signaling, and is required for normal valve morphogenesis and homeostasis in vivo.
this study supports a key role for Mbnl1 loss in the initiation of DM1 cardiac disease.
Differential expression of Mbnl1 in development plays a role in alternative splicing of vesicular trafficking genes in postnatal heart development.
Results show that nuclear localization is a major determinant of MBNL1 function. It promotes the nuclear retention of repeat-containing transcripts, which results in repression of aberrant protein expression from the expanded repeats.
depletion of Mbnl proteins in mouse embryo fibroblasts leads to misregulation of thousands of alternative polyadenylation events.
consistent with a central and negative regulatory role for MBNL proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming
MBNL1 overexpression may be a valuable strategy for treating the skeletal muscle features of Myotonic dystrophy .
Nuclear retention of full-length HTT (show HTT Antibodies) RNA is mediated by splicing factors MBNL1 and U2AF65 (show U2AF59 Antibodies)
muscleblind-like 1 (MBNL1) is a robust suppressor of multiorgan breast cancer metastasis. It binds the 3' untranslated regions of DBNL (show DBNL Antibodies) and TACC1 (show TACC1 Antibodies) -two genes that are implicated as metastasis suppressors.
abnormal splicing of DMD (show DMD Antibodies) exon 78 found in dystrophic muscles of DM1 (show DMPK Antibodies) patients is due to the functional loss of MBNL1 and leads to the re-expression of an embryonic dystrophin (show DMD Antibodies) in place of the adult isoform.
Reduced RBFOX1 (show A2BP1 Antibodies) activity in myotonic dystrophy type 1 tissues may amplify several of the splicing alterations caused by the deficiency in MBNL1.
MBNL1 binds with C allelic pre-miR (show MLXIP Antibodies)-1307 leading to low expression of miR (show MLXIP Antibodies)-1307-3p in colorectal cancer.
The result is consistent with the hypothesis that MBNL proteins are trapped by expanded CUG repeats and inactivated in myotonic dystrophy type 1 (DM1) and that CELF1 is activated in DM1.
Results highlight the importance of RNA binding by MBNL Zinc Finger domains 1 and 2 for splicing regulatory activity, even when the protein is artificially recruited to its regulatory location on target RNAs.
both MBNL1 and MBNL2 are involved in the regulation of Tau exon 2 splicing and the mis-splicing of Tau in DM1 is due to the combined inactivation of both.
Involved in pre-mRNA alternative splicing regulation. Binds to CUG triplet repeat in RNA (By similarity).
, muscleblind-like (Drosophila)
, muscleblind-like protein 1
, muscleblind-like 1
, triplet-expansion RNA-binding protein