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anti-Muscleblind-Like (Drosophila) (MBNL1) Antibodies

Involved in pre-mRNA alternative splicing regulation. Additionally we are shipping MBNL1 Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
MBNL1 56758 Q9JKP5
MBNL1 4154 Q9NR56
MBNL1 282635  
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Top anti-MBNL1 Antibodies at antibodies-online.com

Showing 10 out of 105 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-MBNL1 Antibody Titration: 2.5ug/mlELISA Titer: 1:62500Positive Control: Jurkat cell lysate WB Suggested Anti-MBNL1  Antibody Titration: 2.5 µg/mL ELISA Titer: 1:.2500  Positive Control: Jurkat cell lysate  MBNL1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Goat Un-conjugated ELISA, WB ABIN334433 (1µg/ml) staining of HeLa lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Chicken Rabbit Un-conjugated IHC, WB WB Suggested Anti-MBNL1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:1562500Positive Control: Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB MBNL1 Antibody (C-term) (ABIN1881533) western blot analysis in Jurkat cell line lysates (35 µg/lane). This demonstrates the MBNL1 antibody detected the MBNL1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB 100 μg Log in to see 8 to 10 Days
$493.17
Details
Human Rabbit Un-conjugated IHC, WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Mouse Un-conjugated IF, IHC (p), ELISA, WB Immunofluorescence of monoclonal antibody to MBNL1 on HeLa cell. [antibody concentration 10 ug/ml] MBNL1 monoclonal antibody (M02), clone 3E7 Western Blot analysis of MBNL1 expression in Hela S3 NE . 100 μg Log in to see 9 Days
$430.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 8 to 10 Days
$507.83
Details
Human Mouse Un-conjugated ICC, IF, IHC (p), IHC, WB Detection of Muscleblind in HeLa whole cell extract (33ug) using ABIN258050 at 10ug/ml. 0.1 mL Log in to see 5 to 7 Days
$178.50
Details
Cow Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details

MBNL1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)
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Top referenced anti-MBNL1 Antibodies

  1. Human Polyclonal MBNL1 Primary Antibody for WB - ABIN1881533 : Sen, Talukdar, Liu, Tam, Reddy, Webster: Muscleblind-like 1 (Mbnl1) promotes insulin receptor exon 11 inclusion via binding to a downstream evolutionarily conserved intronic enhancer. in The Journal of biological chemistry 2010 (PubMed)
    Show all 5 references for ABIN1881533

  2. Dog (Canine) Polyclonal MBNL1 Primary Antibody for WB - ABIN2776698 : Adereth, Dammai, Kose, Li, Hsu: RNA-dependent integrin alpha3 protein localization regulated by the Muscleblind-like protein MLP1. in Nature cell biology 2005 (PubMed)
    Show all 3 references for ABIN2776698

  3. Human Polyclonal MBNL1 Primary Antibody for ELISA, WB - ABIN334433 : Warf, Berglund: MBNL binds similar RNA structures in the CUG repeats of myotonic dystrophy and its pre-mRNA substrate cardiac troponin T. in RNA (New York, N.Y.) 2007 (PubMed)

  4. Human Monoclonal MBNL1 Primary Antibody for IF, IHC (p) - ABIN561753 : Rehman, Gladman, Periasamy, Sun, Mahadevan: Development of an AP-FRET based analysis for characterizing RNA-protein interactions in myotonic dystrophy (DM1). in PLoS ONE 2014 (PubMed)

More Antibodies against MBNL1 Interaction Partners

Mouse (Murine) Muscleblind-Like (Drosophila) (MBNL1) interaction partners

  1. Depletion of Mbnl1 and/or Mbnl2 (show MBNL2 Antibodies) reduced localization of hundreds of transcripts, implicating Mbnls in localization of mRNAs to neurites

  2. Sense DMPK (show DMPK Antibodies) RNA foci clearly co-localize with MBNL1 and MBNL2 (show MBNL2 Antibodies) proteins and accumulate in myotonic dystrophy 1 tissues during development.

  3. MBNL1 overexpression promotes transformation of fibroblasts into myofibroblasts.

  4. These data indicate that MBNL1 plays a conserved role in negatively regulating TGFbeta (show TGFB1 Antibodies) signaling, and is required for normal valve morphogenesis and homeostasis in vivo.

  5. this study supports a key role for Mbnl1 loss in the initiation of DM1 cardiac disease.

  6. Differential expression of Mbnl1 in development plays a role in alternative splicing of vesicular trafficking genes in postnatal heart development.

  7. Results show that nuclear localization is a major determinant of MBNL1 function. It promotes the nuclear retention of repeat-containing transcripts, which results in repression of aberrant protein expression from the expanded repeats.

  8. depletion of Mbnl proteins in mouse embryo fibroblasts leads to misregulation of thousands of alternative polyadenylation events.

  9. consistent with a central and negative regulatory role for MBNL proteins in pluripotency, their knockdown significantly enhances the expression of key pluripotency genes and the formation of induced pluripotent stem cells during somatic cell reprogramming

  10. MBNL1 overexpression may be a valuable strategy for treating the skeletal muscle features of Myotonic dystrophy .

Human Muscleblind-Like (Drosophila) (MBNL1) interaction partners

  1. Nuclear retention of full-length HTT (show HTT Antibodies) RNA is mediated by splicing factors MBNL1 and U2AF65 (show U2AF59 Antibodies)

  2. muscleblind-like 1 (MBNL1) is a robust suppressor of multiorgan breast cancer metastasis. It binds the 3' untranslated regions of DBNL (show DBNL Antibodies) and TACC1 (show TACC1 Antibodies) -two genes that are implicated as metastasis suppressors.

  3. Sense DMPK (show DMPK Antibodies) RNA foci clearly co-localize with MBNL1 and MBNL2 (show MBNL2 Antibodies) proteins and accumulate in myotonic dystrophy 1 tissues during development.

  4. abnormal splicing of DMD (show DMD Antibodies) exon 78 found in dystrophic muscles of DM1 (show DMPK Antibodies) patients is due to the functional loss of MBNL1 and leads to the re-expression of an embryonic dystrophin (show DMD Antibodies) in place of the adult isoform.

  5. Reduced RBFOX1 (show A2BP1 Antibodies) activity in myotonic dystrophy type 1 tissues may amplify several of the splicing alterations caused by the deficiency in MBNL1.

  6. MBNL1 binds with C allelic pre-miR (show MLXIP Antibodies)-1307 leading to low expression of miR (show MLXIP Antibodies)-1307-3p in colorectal cancer.

  7. The result is consistent with the hypothesis that MBNL proteins are trapped by expanded CUG repeats and inactivated in myotonic dystrophy type 1 (DM1) and that CELF1 is activated in DM1.

  8. Results show that nuclear localization is a major determinant of MBNL1 function. It promotes the nuclear retention of repeat-containing transcripts, which results in repression of aberrant protein expression from the expanded repeats.

  9. Results highlight the importance of RNA binding by MBNL Zinc Finger domains 1 and 2 for splicing regulatory activity, even when the protein is artificially recruited to its regulatory location on target RNAs.

  10. both MBNL1 and MBNL2 are involved in the regulation of Tau exon 2 splicing and the mis-splicing of Tau in DM1 is due to the combined inactivation of both.

MBNL1 Antigen Profile

Protein Summary

Involved in pre-mRNA alternative splicing regulation. Binds to CUG triplet repeat in RNA (By similarity).

Gene names and symbols associated with MBNL1

  • muscleblind-like (Drosophila) (MBNL1) antibody
  • muscleblind-like (Drosophila) (mbnl1) antibody
  • muscleblind-like 1 (Drosophila) (Mbnl1) antibody
  • muscleblind-like splicing regulator 1 (MBNL1) antibody
  • muscleblind-like splicing regulator 1 (Mbnl1) antibody
  • EXP antibody
  • EXP35 antibody
  • EXP40 antibody
  • EXP42 antibody
  • MBNL antibody
  • MBNL1 antibody
  • mKIAA0428 antibody
  • zgc:153954 antibody

Protein level used designations for MBNL1

muscleblind-like , muscleblind-like (Drosophila) , muscleblind-like protein 1 , muscleblind-like 1 , triplet-expansion RNA-binding protein

GENE ID SPECIES
100218825 Taeniopygia guttata
100559321 Anolis carolinensis
100583541 Nomascus leucogenys
767696 Danio rerio
425033 Gallus gallus
56758 Mus musculus
4154 Homo sapiens
477116 Canis lupus familiaris
781653 Bos taurus
282635 Rattus norvegicus
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