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MYCN is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. Additionally we are shipping MYCN Proteins (7) and MYCN Kits (5) and many more products for this protein.
Showing 10 out of 87 products:
Human Monoclonal MYCN Primary Antibody for ChIP, GS - ABIN152254
Tasseva, Cole, Vance: N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells. in The Journal of biological chemistry 2011
Show all 3 references for ABIN152254
Human Polyclonal MYCN Primary Antibody for EIA, WB - ABIN453206
Alvarez-Rodríguez, Pons: Expression of the proneural gene encoding Mash1 suppresses MYCN mitotic activity. in Journal of cell science 2009
Show all 2 references for ABIN453206
Mouse (Murine) Polyclonal MYCN Primary Antibody for IHC (p), IHC - ABIN256650
Sjostrom, Finn, Hahn, Rowitch, Kenney: The Cdk1 complex plays a prime role in regulating N-myc phosphorylation and turnover in neural precursors. in Developmental cell 2005
Show all 2 references for ABIN256650
Human Polyclonal MYCN Primary Antibody for WB - ABIN391590
Li, Sun, Chen, Squires, Nowroozizadeh, Liang, Huang: p53 Mutation Directs AURKA Overexpression via miR-25 and FBXW7 in Prostatic Small Cell Neuroendocrine Carcinoma. in Molecular cancer research : MCR 2015
Human Polyclonal MYCN Primary Antibody for IF (p), IHC (p) - ABIN760676
Ramraj, Aravindan, Somasundaram, Herman, Natarajan, Aravindan: Serum-circulating miRNAs predict neuroblastoma progression in mouse model of high-risk metastatic disease. in Oncotarget 2016
Dog (Canine) Polyclonal MYCN Primary Antibody for WB - ABIN2779428
Hansford, Thomas, Keating, Burkhart, Peaston, Norris, Haber, Armati, Weiss, Marshall: Mechanisms of embryonal tumor initiation: distinct roles for MycN expression and MYCN amplification. in Proceedings of the National Academy of Sciences of the United States of America 2004
N-myc protein also could bind to the promoter of pri-miR (show MLXIP Antibodies)-4295 and inhibit the expression of RUNX3 (show RUNX3 Antibodies) in glioma cells.
many of the novel findings connect directly or indirectly to regulatory pathways controlling MYCN activity, bringing the old enemy into the spotlight of our current and future targeted drug efforts
Novel pharmacodynamic biomarkers for MYCN protein and PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies)/mTOR (show FRAP1 Antibodies) pathway signaling in children with neuroblastoma (show ARHGEF16 Antibodies).
Authors describe an inverse correlation between WT1 (show WT1 Antibodies) gene expression and MYCN amplification and expression in neuroblastoma (show ARHGEF16 Antibodies) tumors.
The MRN complex is essential to restrain MYCN-induced replication stress during neural cell proliferation.
Oncogenic MYCN re-wires its own interaction and signalling networks to repress regulators of normal cellular developmental processes, such as differentiation.
the expression of MYCN, HMGA2, and DICER1 (show DICER1 Antibodies) seems to be correlated to each other and the expression of the let7-genes impacted by their expression.
N-Myc and activated AKT1 (show AKT1 Antibodies) are sufficient to transform human prostate epithelial cells to prostate adenocarcinoma and neuroendocrine carcinoma. N-Myc is required for tumor maintenance.
This study strongly suggests that AT7519 is a promising drug for the treatment of high-risk neuroblastoma (show ARHGEF16 Antibodies) patients with MYCN amplification.
the MNA (MYCN amplification)subclone appears to be constraint by the tumor environment and thus less relevant for tumor behavior in aggressive tumors with a high genomic instability and many segmental aberrations
Loss of N-myc significantly impairs the Sonic hedgehog (show SHH Antibodies) signaling pathway and disrupts the expression of cell cycle effectors with a significant reduction of Ccnd2 (show CCND2 Antibodies).
Study shows that ground-state embryonic stem cells express low Myc (show MYC Antibodies) levels. Deletion of both c-myc (show MYC Antibodies) and N-myc activity strongly decreases transcription, splicing, and protein synthesis, leading to proliferation arrest; process is reversible and occurs without affecting pluripotency, suggesting that Myc (show MYC Antibodies)-depleted stem cells enter a state of dormancy.
MYCN overexpression is not sufficient for these cells to form tumors in nude mice
ITGA4 (show ITGA4 Antibodies) expression enhances metastasis in MYCN low neuroblastoma (show ARHGEF16 Antibodies).
MYCN plays a critical role in expansion and survival of aggressive medulloblastoma-propagating cells.
SUMOylation may be part of a quality-control mechanism acting on misfolded Myc (show MYC Antibodies) proteins.
The results of this study provided evidence that N-myc deficiency in the olfactory epithelium progressively diminishes proliferation and neurogenesis with negative consequences at structural and cellular levels.
MYCN/LIN28B/Let-7/HMGA2 pathway implicated by meta-analysis of GWAS in suppression of post-natal proliferation thereby potentially contributing to aging
The above results induced by overexpression of MYCN closely resemble the main aspects of human AML (show RUNX1 Antibodies), suggesting that MYCN plays a role in the etiology of AML (show RUNX1 Antibodies).
a general mechanism for p53 (show TP53 Antibodies) inactivation in some embryonal cell types and consequent susceptibility to MycN oncogenesis at the point of embryonal tumor initiation
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas.
N-myc proto-oncogene protein
, class E basic helix-loop-helix protein 37
, neuroblastoma MYC oncogene
, neuroblastoma-derived v-myc avian myelocytomatosis viral related oncogene
, oncogene NMYC
, v-myc avian myelocytomatosis viral related oncogene, neuroblastoma derived
, v-myc myelocytomatosis viral related oncogene, neuroblastoma derived
, Avian myelocytomatosis viral (v-myc) related oncogene neuroblastoma derived (Nmyc)
, Avian myelocytomatosis viral (v-myc) related oncogene, neuroblastoma derived (Nmyc)
, N-myc protein
, neuroblastoma myc-related oncogene 1