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The protein encoded by MYH11 is a smooth muscle myosin belonging to the myosin heavy chain family. Additionally we are shipping MYH11 Kits (17) and MYH11 Proteins (4) and many more products for this protein.
Showing 10 out of 150 products:
Human Polyclonal MYH11 Primary Antibody for IHC, ELISA - ABIN1585256
Staus, Blaker, Medlin, Taylor, Mack: Formin homology domain-containing protein 1 regulates smooth muscle cell phenotype. in Arteriosclerosis, thrombosis, and vascular biology 2011
Show all 2 Pubmed References
Deletion mutation in MYH11 gene causing familial Thoracic aortic dissection was identified in two independent Japanese pedigrees.
Data suggest that expression of MYH11, myosin light chain, and MLCK (myosin-light-chain kinase (show MYLK Antibodies)), is up-regulated in uterine myoma as compared to adjacent smooth muscle cells; expression of MYH11 appears to be involved in cell proliferation.
In familial AAA (show APP Antibodies) we found one pathogenic and segregating variant (COL3A1 (show COL3A1 Antibodies) p.Arg491X), one likely pathogenic and segregating (MYH11 p.Arg254Cys), and fifteen VUS.
CBFB (show CBFB Antibodies) contributes to the transcriptional regulation of ribosomal gene expression and provide further understanding of the epigenetic role of CBFB (show CBFB Antibodies)-SMMHC in proliferation and maintenance of the leukemic phenotype.
we report a novel hypomethylation pattern, specific to CBFB-MYH11 fusion resulting from inv(16) rearrangement in acute myeloid leukemia the expression of which correlated with PBX3 differential methylation
overexpression of MYH11 can lead to increased ER stress and autophagy
MYH11 gene mutation is associated with family history of thoracic aortic aneurysm dissection.
Transcriptional analysis revealed that upon fusion protein knockdown, a small subset of the CBFbeta (show CBFB Antibodies)-MYH11 target genes show increased expression, confirming a role in transcriptional repression
MYH11 mutations are rare and are identified in patients with thoracic aortic aneurysm/dissection.
Incomplete segregation of MYH11 variants with thoracic aortic aneurysms and dissections and patent ductus arteriosus.
Cbfbeta (show CBFB Antibodies)-SMMHC and Nras (show NRAS Antibodies)(G12D) promote the survival of preleukemic myeloid progenitors primed for leukemia by activation of the MEK (show MDK Antibodies)/ERK (show EPHB2 Antibodies)/Bim (show BCL2L11 Antibodies) axis, and define Nras (show NRAS Antibodies)(LSL-G12D); Cbfb (show CBFB Antibodies)(56M) mice as a valuable genetic model for the study of AML (show RUNX1 Antibodies) therapies.
A rare variant in MYH11, R247C, alters myosin contractile function and smooth muscle cell phenotype, leading to increased proliferation in vitro and in response to vascular injury.
Data show the cooperation between mutated KIT and CBFB (show CBFB Antibodies)-MYH11 during leukemogenesis
Cbfb (show CBFB Antibodies)/Runx1 (show RUNX1 Antibodies) repression-independent activities contribute to leukemogenesis by Cbfb (show CBFB Antibodies)-MYH11
Myh11 complexes with Cbfb (show CBFB Antibodies) and inhibits the cell cycle.
report the identification of genes that specifically cooperate with CBFB (show CBFB Antibodies)-MYH11 in leukemogenesis
Force dilatation pressure was decreased in smooth muscle B mysoin null mesenteric vessels. (Myosin B))
provides a mechanistic basis for the myeloid-lineage bias of CBFbeta (show CBFB Antibodies)-SMMHC-associated leukemia
Runx2 (show RUNX2 Antibodies) is expressed in the stem cell compartment, interferes with differentiation and represses CBF (show CEBPZ Antibodies) targets in the myeloid compartment, and modulates the leukemogenic function of Cbfbeta (show CBFB Antibodies)-SMMHC in mouse leukemia.
The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. The gene encoding a human ortholog of rat NUDE1 is transcribed from the reverse strand of this gene, and its 3' end overlaps with that of the latter. The pericentric inversion of chromosome 16
myosin heavy chain 11
, myosin heavy chain, smooth muscle isoform
, myosin, heavy polypeptide 11, smooth muscle
, myosin heavy chain SMA
, myosin heavy chain 21
, smooth muscle myosin heavy chain
, gizzard smooth muscle
, heavy polypeptide 11
, myosin heavy chain, gizzard smooth muscle
, smooth muscle
, myosin heavy chain 11, smooth muscle