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MYLK, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. Additionally we are shipping Myosin Light Chain Kinase Kits (24) and Myosin Light Chain Kinase Proteins (11) and many more products for this protein.
Showing 10 out of 92 products:
Human Polyclonal MYLK Primary Antibody for EIA, IHC (p) - ABIN953458
Al-Sadi, Ye, Dokladny, Ma: Mechanism of IL-1beta-induced increase in intestinal epithelial tight junction permeability. in Journal of immunology (Baltimore, Md. : 1950) 2008
Show all 3 references for ABIN953458
Human Polyclonal MYLK Primary Antibody for ELISA, WB - ABIN1451970
Potier, Chelot, Pekarsky, Gardiner, Rossier, Turnell: The human myosin light chain kinase (MLCK) from hippocampus: cloning, sequencing, expression, and localization to 3qcen-q21. in Genomics 1996
Show all 2 references for ABIN1451970
Human Polyclonal MYLK Primary Antibody for IHC (p), WB - ABIN392495
Rossi, Todd, Daniels, Bazan, Belayev: Interferon Stimulated Gene 15 upregulation precedes the development of blood brain barrier disruption and cerebral edema after traumatic brain injury in young mice. in Journal of neurotrauma 2015
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Human Polyclonal MYLK Primary Antibody for IHC (p), WB - ABIN392494
Rossi, Ralay Ranaivo, Patel, Chrzaszcz, Venkatesan, Wainwright: Albumin causes increased myosin light chain kinase expression in astrocytes via p38 mitogen-activated protein kinase. in Journal of neuroscience research 2011
Show all 2 references for ABIN392494
Human Polyclonal MYLK Primary Antibody for EIA, IHC (p) - ABIN360382
Cantrell: Phosphoinositide 3-kinase signalling pathways. in Journal of cell science 2001
In contrast to mylk2 (show MYLK2 Antibodies) and mylk3 (show MYLK3 Antibodies), mylk1 has a complex structure, and multiple protein products of the mylk1 gene are expressed in most if not all cell types. This review deals with the mylk1 gene and its protein products- multiple MLCK isoforms and noncatalytic KRP/telokin protein. [Review]
Likely pathogenic variants included a TGFB2 (show TGFB2 Antibodies) variant in one patient and a SMAD3 (show SMAD3 Antibodies) variant in another. These variants have been reported previously in individuals with similar phenotypes. Variants of uncertain significance of particular interest included novel variants in MYLK and MFAP5 (show MFAP5 Antibodies), which were identified in a third patient
suggest a novel role for myosin light chain and myosin light chain kinase in advanced glycation end product-induced endothelial hyperpermeability
TKS5 (show SH3PXD2A Antibodies) and MYLK represent two mediators of invasive behavior of cancer cells that are regulated by the ZEB1 (show ZEB1 Antibodies)/miR (show MLXIP Antibodies)-200 feedback loop
We speculate that the drop of the ROCK-to-MLCK ratio may occur as an attempt to compensate for the increased Rho kinase (show ROCK1 Antibodies) activity.
study demonstrates that G. duodenalis-mediated disruption of villin is, at least, in part dependent on activation of myosin light chain kinase (MLCK).
Gene-based association analyses shows nominal significant association with multifocal fibromuscular dysplasia for myosin light chain kinase.
These structure-function studies suggest novel mechanisms for nmMLCK regulation, which may confirm MYLK as a candidate gene in inflammatory lung disease and advance knowledge of the genetic underpinning of lung-related health disparities.
inhibition of p38 MAP kinase (show MAPK14 Antibodies) attenuated the histamine response in all three EC types. Inhibition of RhoA (show RHOA Antibodies), ROCK, or MLCK also prevented the histamine-induced decrease in TER (show TECR Antibodies) in HDMEC.
Fine mapping of the myosin light chain kinase (MYLK) gene replicates the association with asthma in populations of Spanish descent.
Histamine induces myosin light chain (MLC)phosphorylation via MYLK, suggesting regulatory role for MLC in controlling corneal epithelial permeability.
evaluated the spatial arrangement of the catalytic/regulatory domain, three immunoglobulin-related motifs, one fibronectin-related motif, a repetitive, proline-rich segment, and, at the N-terminus, a unique F-actin-binding domain.
telokin may play a role in attenuating constitutive myosin light chain phosphorylation
MLCK is linked to timely blastocyst formation, though it is dispensable for oocyte meiotic maturation
NF-kappaB (show NFKB1 Antibodies) novel partner within endothelial cells
MLCK regulates cell migration in a myosin regulatory light chain phosphorylation-independent mechanism.
nmMlck modulates IL-1beta (show IL1B Antibodies)-mediated downregulation of Cldn5 (show CLDN5 Antibodies) in brain microvascular endothelial cells.
a prominent effect of the multifunctional microRNA-155 in endothelial cells is modulation of phenotype through alterations in RhoA, myosin light chain kinase expression, and actin cytoskeleton organization
CArG element in intron 15 of the mylk1 gene is necessary for maximal expression of the 130-kDa smMLCK and that the 130-kDa smMLCK isoform is specifically required to regulate smooth muscle contractility
In immune-mediated inflammatory bowel disease, tight junction dysregulation and barrier loss is induced by MLCK, but at advanced stages, barrier loss is MLCK-independent.
Claudin-2 (show CLDN2 Antibodies) assumes an important role in colorectal inflammation, and furthermore implicates the involvement of MLCK in colon inflammation.
involved in IL-1beta (show IL1B Antibodies)-induced increase in intestinal permeability
This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.
kinase related protein, telokin
, myosin, light chain kinase
, myosin light chain kinase
, myosin light chain kinase, smooth muscle-like
, kinase-related protein
, myosin light chain kinase, smooth muscle
, myosin, light polypeptide kinase
, smooth muscle myosin light chain kinase
, smooth muscle myosin light chain kinase (61-kDa active fragment)