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In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. Additionally we are shipping MX1 Proteins (8) and MX1 Kits (4) and many more products for this protein.
Showing 10 out of 105 products:
Human Polyclonal MX1 Primary Antibody for EIA, WB - ABIN953553
van der Voort, Vennegoor, Visser, Knol, Uitdehaag, Barkhof, Oudejans, Polman, Killestein: Spontaneous MxA mRNA level predicts relapses in patients with recently diagnosed MS. in Neurology 2010
Show all 3 references for ABIN953553
Human Monoclonal MX1 Primary Antibody for WB - ABIN1539914
Swick, Baltes, Yin: Visualizing infection spread: dual-color fluorescent reporting of virus-host interactions. in Biotechnology and bioengineering 2014
Show all 2 references for ABIN1539914
Human Polyclonal MX1 Primary Antibody for WB - ABIN518110
Gal-Tanamy, Bachmetov, Ravid, Koren, Erman, Tur-Kaspa, Zemel: Vitamin D: an innate antiviral agent suppressing hepatitis C virus in human hepatocytes. in Hepatology (Baltimore, Md.) 2011
Cow (Bovine) Polyclonal MX1 Primary Antibody for WB - ABIN2782470
Hoenen, Liu, Kochs, Khromykh, Mackenzie: West Nile virus-induced cytoplasmic membrane structures provide partial protection against the interferon-induced antiviral MxA protein. in The Journal of general virology 2007
Cow (Bovine) Monoclonal MX1 Primary Antibody for EIA, WB - ABIN781793
Haller, Kochs: Interferon-induced mx proteins: dynamin-like GTPases with antiviral activity. in Traffic (Copenhagen, Denmark) 2002
Mouse Mx1 was shown to be essential for interferon (show IFNA Antibodies) type I-dependent protective immunity against primary influenza. (Review)
In Mx1-intact mice with weakened resistance due to deficiencies in Mavs (show MAVS Antibodies) and Tlr7 (show TLR7 Antibodies), an elevated respiratory bacterial burden was found.
Functional Comparison of Mx1 from Two Different Mouse Species Reveals the Involvement of Loop L4 in the Antiviral Activity against Influenza A Viruses.
we show that, very unexpectedly, congenic D2-Mx1(r/r) mice carrying the wild-type Mx1 gene from the A2G strain are not fully protected against lethal influenza virus infections
dysregulated gene transcriptional activity corresponded to persistent induction of cytokine/chemokines and recruitment of cytokine-producing cells that promote inflammation in B6-Mx1(-/-) mouse lungs.
Mice with a functional Mx1 generate a strong antiviral state by downregulating key modulator molecules associated with influenza virus lethality.
functional Mx1 did not alter olfactory bulb invasion by virus but attenuated illness compared to knockout Mx1 mice
nuclear MxA suppresses the influenza virus transcription by interacting not only with RNA polymerase subunit PB2 but also with influenza NP
Thogoto virus mutant lacking protein ML was strongly attenuated in mice carrying the interferon (show IFNA Antibodies)-responsive Mx1 gene
A variant of influenza A virus strain A/PR/8/34 (H1N1) exhibits normal sensitivity to growth restriction by Mx1; the virus is well controlled in Mx1-expressing but not Mx1-null mice.
A significant association was observed between MX1 -88G/T SNP and susceptibility to systemic lupus erythematosus
Study shows different levels of expression of MxA in each breast cancer subtype and its close relationship with tumor-infiltrating lymphocytes. MxA protein expression was higher in triple-negative breast cancer and correlated with a higher histologic grade.
This study demonstrated that MxA mRNA expression of interferon beta (show IFNB1 Antibodies) response in multiple sclerosis patients.
Transient dimerization of human MxA promotes GTP (show AK3 Antibodies) hydrolysis.The GTPase (show RACGAP1 Antibodies) domains of Mx proteins dimerize transiently to facilitate catalysis.
polymorphism at position -88 in the MxA promoter region might be a potential biomarker to predict HCV progression toward end-stage fibrosis and response to IFN-based therapy in chronic hepatitis C patients.
data suggest that, during infection, a fraction of MxA disassembles into dimers that bind to NP synthesized following primary transcription in the cytoplasm, thereby preventing viral replication
heterozygosity for both -88G/T and -123C/A polymorphisms of the MxA gene is important host factor that influence the response to IFN therapy in patients with chronic HCV infection.
E2F1 (show E2F1 Antibodies) transcripts and miR-17-5p were significantly downregulated while c-Myc (show MYC Antibodies) and MxA transcripts were significantly upregulated in SLE.
Baseline MxA mRNA levels may be useful for predicting whether multiple sclerosis patients will respond or not to interferon-beta (show IFNB1 Antibodies) treatment.
Blood MxA protein levels are increased in young children with symptomatic respiratory virus infections, including rhinovirus infections. MxA is an informative general marker for the most common acute virus infections.
The deletion/insertion polymorphism in exon 14 of the Mx1 gene, which causes a frame shift, showed no significant association with growth or viremia after PRRSV infection.
the SINE insertion polymorphism at site -547 of the MX1 gene promoter region is a potential DNA marker for porcine reproductive and respiratory syndrome resistance
Overexpression of porcine Mx1 induce a robust immune response against foot-and-mouth disease virus.
Studied the effects of porcine Mx1 protein on FMDV and BVDV replication by measuring viral reverse transcriptase activity at various time intervals.
Polymorphisms in Mx1 are significantly associated with immunological traits in Landrace piglets and have potential application value for marker-assisted selection of pig breeding with disease resistance.
Porcine Mx1 protein inhibits replication of influenza A virus, and impairs the traffic of the endocytic vesicles to the late endosomes.
The 11-bp deletion Mx1 mutant is lacking antiviral activity able to contribute to the interference of influenza virus replication.
Data showed that there were abundant MX1 gene polymorphisms in all pig breeds.
Sequencing of the 332-bp MX1 promoter region identified 15 substitutions and insertions at three positions in 21 pigs from 15 breeds, in which nine genotypes were classified.
MX1-a, MX1B and MX2 (show MX2 Antibodies) are affected by the type I IFN pathway during pregnancy and are involved in an immune response to protect the mother and fetus
The replication levels of foot-and-mouth disease virus RNA were promoted by silencing bovine Mx1.
Overexpression of bovine Mx1 protein inhibits the replication of foot-and-mouth disease virus.
Data indicate that the expression profiles of ISG15 (show ISG15 Antibodies), MX1, MX2 (show MX2 Antibodies), and OAS1 (show OAS1 Antibodies) could be a useful diagnostic biomarker of gestation.
The proximal GC boxes were found to be essential for IFN response in the bovine Mx1 promoter with the deletion mutants.
Mx1 is cytoplasmic. Mx1B is mainly nuclear. An Arg-rich nuclear localization signal was found in 27 AAs (show FGD1 Antibodies) specific for Mx1B. N-terminus-deleted Mx1B is only cytoplasmic. The deleted-Mx1B-expressing cells had positive antiviral activity against VSVDeltaG*-G.
A new bovine Mx gene (designated Mx1B) was isolated from the endometrial cDNA library of the early pregnant cow.
In mouse, the interferon-inducible Mx protein is responsible for a specific antiviral state against influenza virus infection. The protein encoded by this gene is similar to the mouse protein as determined by its antigenic relatedness, induction conditions, physicochemical properties, and amino acid analysis. This cytoplasmic protein is a member of both the dynamin family and the family of large GTPases. Two transcript variants encoding the same protein have been found for this gene.
Myxovirus (influenza) resistance homolog of murine Mx (also interferon-inducible protein IFI78)
, Myxovirus (influenza) resistance, homolog of murine Mx (also interferon-inducible protein IFI78)
, interferon-induced GTP-binding protein Mx1
, myxoma resistance protein 1
, myxovirus resistance protein 1
, myxovirus (influenza) resistance 1 polypeptide
, interferon-regulated resistance GTP-binding protein MxA
, GTP-binding protein
, interferon-inducible myxovirus resistance-1 protein
, interferon-inducible protein p78
, myxovirus (influenza) resistance 1, (murine homolog)
, GTP-binding protein Mx1
, oligodendrocyte GTP-binding protein
, oligodendrocyte nucleotide-binding protein