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N-Acetylglucosamine-1-phosphodiester alpha-N-Acetylglucosaminidase Proteins (NAGPA)

Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. Additionally we are shipping NAGPA Antibodies (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NAGPA 51172 Q9UK23
NAGPA 27426 Q8BJ48
Rat NAGPA NAGPA 360476  
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Top NAGPA Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NAGPA Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
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Mouse (Murine) ,
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More Proteins for N-Acetylglucosamine-1-phosphodiester alpha-N-Acetylglucosaminidase (NAGPA) Interaction Partners

Human N-Acetylglucosamine-1-phosphodiester alpha-N-Acetylglucosaminidase (NAGPA) interaction partners

  1. SNPs covering GNPTAB (show GNPTAB Proteins), GNPTG (show GNPTG Proteins) and NAGPA were subjected to genotyping, association analysis was performed on all SNPs. Significant association of rs17031962 in GNPTAB (show GNPTAB Proteins) and rs882294 in NAGPA with developmental dyslexia in a Chinese population was identified after false discovery rate correction for multiple comparisons.

  2. To date mutations in GNPTAB (show GNPTAB Proteins), GNPTG (show GNPTG Proteins), and NAGPA have been associated with stuttering. These genes encode the lysosomal enzyme targeting pathway, defective in mucolipidosis. (Review)

  3. Analysis of mannose 6-phosphate uncovering enzyme mutations associated with persistent stuttering.

  4. identified three mutations in the NAGPA gene associated with stuttering

  5. synthesis as a proenzyme that is activated by furin (show FURIN Proteins) [mannose 6-phosphate-uncovering enzyme]

  6. The mannose 6-phosphate uncovering enzyme participates in the uncovering of the mannose 6-phosphate recognition tag on lysosomal enzymes, a process that facilitates recognition of those enzymes by mannose 6-phosphate receptors to delivery to lysosomes.

Mouse (Murine) N-Acetylglucosamine-1-phosphodiester alpha-N-Acetylglucosaminidase (NAGPA) interaction partners

  1. UCE -/- mice were viable, grew normally & lacked detectable histologic abnormalities, but plasma levels of 6 acid hydrolases were elevated. UCE accounts for all the uncovering activity in the Golgi.

NAGPA Protein Profile

Protein Summary

Hydrolases are transported to lysosomes after binding to mannose 6-phosphate receptors in the trans-Golgi network. This gene encodes the enzyme that catalyzes the second step in the formation of the mannose 6-phosphate recognition marker on lysosomal hydrolases. Commonly known as 'uncovering enzyme' or UCE, this enzyme removes N-acetyl-D-glucosamine (GlcNAc) residues from GlcNAc-alpha-P-mannose moieties and thereby produces the recognition marker. This reaction most likely occurs in the trans-Golgi network. This enzyme functions as a homotetramer of two disulfide-linked homodimers. In addition to having an N-terminal signal peptide, the protein's C-terminus contains multiple signals for trafficking it between lysosomes, the plasma membrane, and trans-Golgi network.

Gene names and symbols associated with NAGPA

  • N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA)
  • N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAEGRDRAFT_56913)
  • N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (Nagpa)
  • AI596180 protein
  • APAA protein
  • NAGPA protein
  • UCE protein

Protein level used designations for NAGPA

N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase , alpha-N-acetylglucosaminyl phosphodiesterase , lysosomal alpha-N-acetylglucosaminidase , mannose 6-phosphate-uncovering enzyme , phosphodiester alpha-GlcNAcase , alpha-GlcNAcase

GENE ID SPECIES
416395 Gallus gallus
490019 Canis lupus familiaris
8849914 Naegleria gruberi strain NEG-M
100399724 Callithrix jacchus
51172 Homo sapiens
27426 Mus musculus
360476 Rattus norvegicus
515935 Bos taurus
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