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NDRG1 is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. Additionally we are shipping N-Myc Downstream Regulated 1 Proteins (17) and N-Myc Downstream Regulated 1 Kits (6) and many more products for this protein.
Showing 10 out of 131 products:
Human Monoclonal NDRG1 Primary Antibody for IHC (p), ELISA - ABIN393210
Murakami, Hosoi, Izumi, Maruyama, Ureshino, Watari, Kohno, Kuwano, Ono: Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells. in Biochemical and biophysical research communications 2010
Show all 5 references for ABIN393210
Human Polyclonal NDRG1 Primary Antibody for IHC, ELISA - ABIN184872
Zhou, Salnikow, Costa: Cap43, a novel gene specifically induced by Ni2+ compounds. in Cancer research 1998
Human Polyclonal NDRG1 Primary Antibody for FACS, IHC (p) - ABIN390922
Sugiyama, Masuda, Shinoda, Nakamura, Tomita, Ishihama: Phosphopeptide enrichment by aliphatic hydroxy acid-modified metal oxide chromatography for nano-LC-MS/MS in proteomics applications. in Molecular & cellular proteomics : MCP 2007
Chicken Polyclonal NDRG1 Primary Antibody for WB - ABIN2783176
Chen, Nelson, Sadovsky: N-myc down-regulated gene 1 modulates the response of term human trophoblasts to hypoxic injury. in The Journal of biological chemistry 2006
Also, overexpression of AHR facilitated cell proliferation and migration via up-regulation of NDRG1.
NDRG1 inhibits stemness of colorectal cancer via down-regulation of nuclear beta-catenin (show CTNNB1 Antibodies) and CD44 (show CD44 Antibodies)
Data suggest that, in colonic/prostatic neoplasm cells, increased expression of NDRG1 decreases activating phosphorylation of FAK and paxillin; silencing/inhibition of NDRG1 results in opposite effect and inhibits neoplasm cell migration/adhesion.
Data indicate that N-myc downstream regulated gene 1 (NDRG1) competitively bind to glycogen synthase kinase 3beta (GSK-3beta (show GSK3b Antibodies)) and orphan nuclear receptor (Nur77 (show NR4A1 Antibodies)) to prevent beta-catenin (show CTNNB1 Antibodies) degradation.
Data suggest that NDRG1 down-regulates expression and activation of HER1/EGFR (show EGFR Antibodies), HER2/ERBB2 (show ERBB2 Antibodies), and HER3/ERBB3 (show ERBB3 Antibodies) in response to epidermal growth factor (EGF (show EGF Antibodies)) ligand in pancreatic/colonic neoplasm cells.
pomegranate juice-mediated decrease in cell death in hypoxia is partially mediated by NDRG1 in BeWo cells but not in primary trophoblasts.
Results show that aberrant methylation of NDRG1 promoter is an important mechanism for gene silencing, playing a major role in tumor occurrence and progression of protate cancer (Pca (show FLVCR1 Antibodies)). Reversing this process may be used for PCa (show FLVCR1 Antibodies) treatment.
NDRG1 could increase the resistance of neuroblastoma (show ARHGEF16 Antibodies) cells to chemotherapeutic drugs, with its positive regulation on drug resistant proteins.
NDRG1 decreases phosphorylation of c-Src at Tyr416 by down-regulating EGFR expression and activation. It also affected Rac1, p130Cas, CrkII, and c-Abl. NDRG1 decreases cell migration via c-src inhibition.
Overexpression of NDRG1 inhibits human glioma proliferation and invasion via phosphoinositide 3-kinase/AKT (show AKT1 Antibodies) pathways.
NDRG1 deficiency attenuates the differentiation of macrophage lineage cells, suppressing bone remodeling and inflammatory angiogenesis. This study strongly suggests the crucial role of NDRG1 in differentiation process for macrophages.
Using double knockout of NDR1 (show STK38 Antibodies) and 2 shows that NDRs acted downstream of MST1 (show MST1 Antibodies) to mediate the egress of mature thymocytes from the thymus, as well as the interstitial migration of naive T cells within popliteal lymph nodes.
Ndrg1 is phosphorylated and degraded by CD28 (show CD28 Antibodies) signalling in a proteasome-dependent manner.
Ndr1 (show STK38 Antibodies)/2-double null embryos show defects in somitogenesis and cardiac looping, which reveals their essential functions and shows that the NDR (show STK38 Antibodies) kinases are critically required during the early phase of organogenesis
Rassf5 (show RASSF5 Antibodies) and Ndr1 (show STK38 Antibodies) or Ndr2 (show STK38L Antibodies) kinases regulate neuronal polarity through Par3 (show F2RL2 Antibodies) phosphorylation.
NDRG1 promotes fetal growth and regulates the metabolic response to intrauterine hypoxic injury in a sexually dichotomous manner
early growth response 1 (show EGR1 Antibodies), a transcription factor that binds to the NDRG1 promoter, was mediated in the NDRG1 expression regulation by PKD2 (show PKD2 Antibodies).
Our findings do not support the proposed roles of NDRG1 in growth arrest, terminal differentiation, gene expression regulation and proteasomal degradation.
Nickel induces HIF-1 (show HIF1A Antibodies) transactivation and Cap43 protein expression through a PI-3K/Akt (show AKT1 Antibodies)-dependent and p70(S6k (show RPS6KB1 Antibodies))-independent pathway.
results indicate that NDRG1 deficiency leads to Schwann cell dysfunction, suggesting that NDRG1 is essential for maintenance of the myelin sheaths in peripheral nerves
NDR1 plays a broad role both in mediating primary cellular functions in Arabidopsis through maintaining the integrity of the cell wall-plasma membrane connection and as a key signaling component of these responses during pathogen infection.
SR1 plays an important role in plant immunity and ethylene signaling by directly regulating NDR1 and EIN3.
The induction of defence responses and disease resistance to X. campestris pv. campestris strain 8004 requires NDR1 , RAR1 and SGT1b, suggesting that effector-triggered immunity plays a large role in resistance to this strain.
Sequence analysis and mass spectrometry suggest that NDR1 (show STK38 Antibodies) is localized to the PM via a C-terminal glycosylphosphatidyl-inositol (GPI (show GPI Antibodies)) anchor.
demonstrate that the RIN4-NDR1 interaction occurs on the cytoplasmically localized N-terminal portion of NDR1 and that this interaction is required for the activation of resistance signaling following infection by P. syringae
Mutations in NDR1 (show STK38 Antibodies) abolished the enhanced resistance of dnd (show DND1 Antibodies) mutants against Pseudomonas syringae pv. tomato and Hyaloperonospora parasitica but not Botrytis cinerea.
This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
N-myc downstream regulated gene 1
, N-myc downstream regulated 1
, N-myc downstream-regulated gene 1 protein
, differentiation-related gene 1 protein
, nickel-specific induction protein Cap43
, protein NDRG1
, protein regulated by oxygen-1
, reducing agents and tunicamycin-responsive protein
, protein NDRG1-B
, protein Ndr1