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Ceramidases (EC 18.104.22.168), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Additionally we are shipping ASAH2 Antibodies (51) and ASAH2 Kits (3) and many more products for this protein.
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The structural basis for ceramide recognition and hydrolysis by human neutral ceramidase has been uncovered.
These results demonstrate for the first time that adiponectin (show ADIPOQ Proteins) inhibits TNFalpha (show TNF Proteins)-induced inflammatory response via Cav1 (show CAV1 Proteins)-mediated ceramidase recruitment and activation in an AdipoR1 (show ADIPOR1 Proteins)-dependent fashion.
cloned a 3000 bp region upstream of the translational start site of the nCDase gene
c-Jun/AP-1 (show JUN Proteins) signaling may, in part, regulate serum-induced nCDase gene transcription
Both acidic ceramidase (aCDase) and neutral ceramidase (nCDase) activities declined after low- and high-UVB, but returned to normal only in low-UVB cells
Blocking acid ceramidase (show ASAH1 Proteins) but not sphingosine kinase activity in alveolar macrophages led to decreased ERK (show EPHB2 Proteins) and Akt (show AKT1 Proteins) activity and induction of cell death.
Neutral ceramidase is localized mainly in plasma membranes.
the present study identified a novel amidase (show GATA1 Proteins) sequence containing a critical serine residue that may function as a nucleophile in the hydrolytic attack on the amide bond present in ceramide
Important for the generation of sphgosine 1 phosphqte (S1P (show MBTPS1 Proteins)) and S1P (show MBTPS1 Proteins)-mediated cell proliferation and survival.
the purification and characterization of neutral ceramidase from human ileostomy content, using octanoyl-[(14)C]sphingosine as substrate
These results suggest that neutral ceramidase is a mediator of necroptosis and might be a novel therapeutic target for protection from ischaemic injury.
Knocking down NCDase reduced sphingosine accumulation in mitochondria and preserved COX (show CPOX Proteins) activity after the brain injury.
Neutral ceramidase deficiency increases inflammation in a mouse model of inflammatory bowel disease.
Novel pathway of ceramide production in mitochondria: thioesterase (show FASN Proteins) and neutral ceramidase produce ceramide from sphingosine and acyl-CoA (show GNPAT Proteins).
the predicted HNF-4alpha binding site identified in the Asah2 promoter is functional
molecular cloning of the mouse neutral ceramidase gene and its promoter analysis
Neutral ceramidase secreted by endothelial cells is released in part associated with caveolin-1 (show CAV1 Proteins).
the Asah2-encoded neutral ceramidase is a key enzyme for the catabolism of dietary sphingolipids and regulates the levels of bioactive sphingolipid metabolites in the intestinal tract
This enzyme is decreased in the small intestine in CFTR (show CFTR Proteins) transgenic mice with a deletion in CFTR (show CFTR Proteins)>
Ceramidases (EC 22.214.171.124), such as ASAH2, catalyze hydrolysis of the N-acyl linkage of ceramide, a second messenger in a variety of cellular events, to produce sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger (see MIM 603730) (Mitsutake et al., 2001
N-acylsphingosine amidohydrolase 2
, acylsphingosine deacylase 2
, mitochondrial ceramidase
, neutral ceramidase
, neutral/alkaline ceramidase
, non-lysosomal ceramidase