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anti-NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Antibodies

The protein encoded by NAE1 binds to the beta-amyloid precursor protein. Additionally we are shipping NAE1 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NAE1 8883 Q13564
NAE1 84019  
NAE1 234664 Q8VBW6
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Top anti-NAE1 Antibodies at antibodies-online.com

Showing 10 out of 98 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB NAE1 Antibody (Center) (ABIN656991) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Formalin-fixed and paraffin-embedded human testis tissue reacted with APPBP1 antibody (C-term) , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. Western blot analysis of APPBP1 (arrow) using rabbit polyclonal APPBP1 Antibody (C-term) (AP13996PU-N ). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the APPBP1 gene (Lane 2) (Origene Technologies). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of APPBP1 (arrow) using rabbit polyclonal APPBP1 Antibody (C-term) (ABIN391421).293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the APPBP1 gene (Lane 2) (Origene Technologies). Formalin-fixed and paraffin-embedded human testis tissue reacted with APPBP1 antibody (C-term) (ABIN391421), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-APPBP1 Antibody (C-term) (ABIN391418) in mouse brain tissue lysates (35 µg/lane). APPBP1(arrow) was detected using the purified polyclonal antibody (1:60 dilution). Western blot analysis of APP-BP1(arrow) using rabbit polyclonal APP-BP1 Antibody (C-term) (ABIN391418). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the APP-BP1 gene (Lane 2) (Origene Technologies). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue reacted with APPBP1 Antibody (Center) followed which was peroxidase conjugated to the secondary antibody and followed by DAB staining. Western blot analysis of APPBP1 Antibody (Center) in K562,293 cell line lysates (35ug/lane). 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Dog Mouse Un-conjugated IF, WB Western blot analysis of APP-BP1 on a RSV-3T3 cell lysate. Lane 1: 1:1000, lane 2: 1:2000, lane 3: 1:4000 dilution of the mouse anti- APP-BP1 antibody. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated WB Host: Rabbit  Target Name: Nae1  Sample Tissue: Mouse Lung lysates  Antibody Dilution: 1.0 µg/mL 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Anti- APPBP1 Picoband antibody, Western blotting All lanes: Anti APPBP1  at 0.5ug/ml WB: Recombinant Human APPBP1 Protein 0.5ng Predicted bind size: 42KD Observed bind size: 42KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (84.85 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Mouse Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details

NAE1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-NAE1 Antibodies

  1. Human Polyclonal NAE1 Primary Antibody for IHC (p), WB - ABIN391418 : Chen, Liu, McPhie, Hassinger, Neve: APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. in The Journal of cell biology 2003 (PubMed)
    Show all 3 references for ABIN391418

  2. Dog (Canine) Monoclonal NAE1 Primary Antibody for IF, WB - ABIN968684 : Chen, McPhie, Hirschberg, Neve: The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. in The Journal of biological chemistry 2000 (PubMed)
    Show all 3 references for ABIN968684

  3. Human Polyclonal NAE1 Primary Antibody for IHC (p), WB - ABIN391421 : Walden, Podgorski, Schulman: Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8. in Nature 2003 (PubMed)
    Show all 3 references for ABIN391421

  4. Human Polyclonal NAE1 Primary Antibody for EIA, IHC (p) - ABIN359512 : Chen, Liu, Naumovski, Neve: ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis. in Journal of neurochemistry 2003 (PubMed)
    Show all 3 references for ABIN359512

  5. Human Polyclonal NAE1 Primary Antibody for ELISA, WB - ABIN563864 : Konforti: More than the sum of its parts. in Cell reports 2012 (PubMed)
    Show all 2 references for ABIN563864

  6. Human Polyclonal NAE1 Primary Antibody for EIA, IHC (p) - ABIN950470 : Jung, Briolat, Millon, de Reyniès, Rickman, Thomas, Abecassis, Clavel, Wasylyk: Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma. in International journal of cancer. Journal international du cancer 2010 (PubMed)
    Show all 2 references for ABIN950470

  7. Human Polyclonal NAE1 Primary Antibody for IHC (p), WB - ABIN656991 : Park, Yoon, Yoon: TRIP12 functions as an E3 ubiquitin ligase of APP-BP1. in Biochemical and biophysical research communications 2008 (PubMed)

More Antibodies against NAE1 Interaction Partners

Fruit Fly (Drosophila melanogaster) NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) interaction partners

  1. Study shows that APP-BP1 specifically binds the intracellular domain of APP-like (show APP Antibodies) protein (APPL (show APP Antibodies)), APP-BP1 mutation partially suppresses the abnormal macrochaete phenotype of Appl (show APP Antibodies)(d), while overexpression of dAPP-BP1 causes abnormal macrochaetes.

Human NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) interaction partners

  1. E1 (NAE1 and UBA3 (show UBA3 Antibodies)) and E2 (UBC12 (show ube2m Antibodies)) enzymes, as well as global NEDD8 (show NEDD8 Antibodies) conjugation, were upregulated in over 2/3 of human intrahepatic cholangiocarcinoma

  2. analysis of a metal-based inhibitor of NEDD8 (show NEDD8 Antibodies)-activating enzyme

  3. our results suggest that APP-BP1 modulates neuronal differentiation by altering gene expression profiles in fetal neural stem cells

  4. APP-BP1 plays an important role in the cell cycle progression of fetal neural stem cells

  5. APP-BP1 displayed decreased expression levels in HPV-positive head and neck squamous cell carcinoma

  6. structure and mutational analysis of human APPBP1-UBA3 (show UBA3 Antibodies), the heterodimeric E1 enzyme (show ENOPH1 Antibodies) for NEDD8 (show NEDD8 Antibodies)

  7. Conservation in the mechanism of Nedd8 (show NEDD8 Antibodies) activation by the human AppBp1-Uba3 (show UBA3 Antibodies) heterodimer.

  8. Data report the structure of the quaternary complex between human APPBP1-UBA3 (show UBA3 Antibodies), a heterodimeric E1, its ubl NEDD8 (show NEDD8 Antibodies), and ATP.

  9. APP-BP1 is degraded by ubiquitin-dependent proteolysis.

Mouse (Murine) NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) interaction partners

  1. APP-BP1 plays an important role in the cell cycle progression of fetal neural stem cells

NAE1 Antigen Profile

Protein Summary

The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NAE1

  • beta-Amyloid precursor protein binding protein 1 (APP-BP1) antibody
  • NEDD8 activating enzyme E1 subunit 1 (NAE1) antibody
  • NEDD8 activating enzyme E1 subunit 1 (Nae1) antibody
  • NEDD8 activating enzyme E1 subunit 1 (nae1) antibody
  • nedd8 activating enzyme E1 subunit 1 (nae1) antibody
  • Protein ULA-1 (ula-1) antibody
  • 59kDa antibody
  • A-116A10.1 antibody
  • anon-WO0140519.225 antibody
  • appbp1 antibody
  • CG7828 antibody
  • dAPP-BP1 antibody
  • dAPPBP1 antibody
  • Dmel\\CG7828 antibody
  • ula-1 antibody
  • zgc:66148 antibody

Protein level used designations for NAE1

APP-BP1-PA , APP-BP1-PB , CG7828-PA , CG7828-PB , APP-BP1 , NEDD8-activating enzyme E1 regulatory subunit , NEDD8-activating enzyme E1 subunit , amyloid beta precursor protein binding protein 1, 59kDa , amyloid beta precursor protein-binding protein 1, 59 kDa , amyloid beta precursor protein-binding protein 1, 59kD , amyloid protein-binding protein 1 , proto-oncogene protein 1 , protooncogene protein 1 , APP-binding protein 1 , amyloid beta precursor protein binding protein 1

GENE ID SPECIES
39244 Drosophila melanogaster
8883 Homo sapiens
84019 Rattus norvegicus
234664 Mus musculus
415792 Gallus gallus
414612 Xenopus laevis
573336 Danio rerio
610026 Canis lupus familiaris
266650 Caenorhabditis elegans
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