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The protein encoded by NAE1 binds to the beta-amyloid precursor protein. Additionally we are shipping NAE1 Proteins (6) and many more products for this protein.
Showing 10 out of 98 products:
Dog (Canine) Monoclonal NAE1 Primary Antibody for IF, WB - ABIN968684
Chen, McPhie, Hirschberg, Neve: The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. in The Journal of biological chemistry 2000
Show all 3 references for ABIN968684
Human Polyclonal NAE1 Primary Antibody for IHC (p), WB - ABIN391421
Chen, Liu, McPhie, Hassinger, Neve: APP-BP1 mediates APP-induced apoptosis and DNA synthesis and is increased in Alzheimer's disease brain. in The Journal of cell biology 2003
Show all 3 references for ABIN391421
Human Polyclonal NAE1 Primary Antibody for EIA, IHC (p) - ABIN4620399
Chen, Liu, Naumovski, Neve: ASPP2 inhibits APP-BP1-mediated NEDD8 conjugation to cullin-1 and decreases APP-BP1-induced cell proliferation and neuronal apoptosis. in Journal of neurochemistry 2003
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Human Polyclonal NAE1 Primary Antibody for IHC (p), WB - ABIN391418
Walden, Podgorski, Schulman: Insights into the ubiquitin transfer cascade from the structure of the activating enzyme for NEDD8. in Nature 2003
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Human Polyclonal NAE1 Primary Antibody for ELISA, WB - ABIN563864
Konforti: More than the sum of its parts. in Cell reports 2012
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Human Polyclonal NAE1 Primary Antibody for EIA, IHC (p) - ABIN950470
Jung, Briolat, Millon, de Reyniès, Rickman, Thomas, Abecassis, Clavel, Wasylyk: Biological and clinical relevance of transcriptionally active human papillomavirus (HPV) infection in oropharynx squamous cell carcinoma. in International journal of cancer. Journal international du cancer 2010
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Human Polyclonal NAE1 Primary Antibody for IHC (p), WB - ABIN656991
Park, Yoon, Yoon: TRIP12 functions as an E3 ubiquitin ligase of APP-BP1. in Biochemical and biophysical research communications 2008
Study shows that APP-BP1 specifically binds the intracellular domain of APP-like (show APP Antibodies) protein (APPL (show APP Antibodies)), APP-BP1 mutation partially suppresses the abnormal macrochaete phenotype of Appl (show APP Antibodies)(d), while overexpression of dAPP-BP1 causes abnormal macrochaetes.
E1 (NAE1 and UBA3 (show UBA3 Antibodies)) and E2 (UBC12 (show ube2m Antibodies)) enzymes, as well as global NEDD8 (show NEDD8 Antibodies) conjugation, were upregulated in over 2/3 of human intrahepatic cholangiocarcinoma
analysis of a metal-based inhibitor of NEDD8 (show NEDD8 Antibodies)-activating enzyme
our results suggest that APP-BP1 modulates neuronal differentiation by altering gene expression profiles in fetal neural stem cells
APP-BP1 plays an important role in the cell cycle progression of fetal neural stem cells
APP-BP1 displayed decreased expression levels in HPV-positive head and neck squamous cell carcinoma
structure and mutational analysis of human APPBP1-UBA3 (show UBA3 Antibodies), the heterodimeric E1 enzyme (show ENOPH1 Antibodies) for NEDD8 (show NEDD8 Antibodies)
Conservation in the mechanism of Nedd8 (show NEDD8 Antibodies) activation by the human AppBp1-Uba3 (show UBA3 Antibodies) heterodimer.
Data report the structure of the quaternary complex between human APPBP1-UBA3 (show UBA3 Antibodies), a heterodimeric E1, its ubl NEDD8 (show NEDD8 Antibodies), and ATP.
APP-BP1 is degraded by ubiquitin-dependent proteolysis.
The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.
, NEDD8-activating enzyme E1 regulatory subunit
, NEDD8-activating enzyme E1 subunit
, amyloid beta precursor protein binding protein 1, 59kDa
, amyloid beta precursor protein-binding protein 1, 59 kDa
, amyloid beta precursor protein-binding protein 1, 59kD
, amyloid protein-binding protein 1
, proto-oncogene protein 1
, protooncogene protein 1
, APP-binding protein 1
, amyloid beta precursor protein binding protein 1