NAE1 antibody (Regulatory Subunit)

Catalog No. ABIN7161137

Product Details anti-NAE1 Antibody

Target: NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))

Binding Specificity: AA 1-220, Regulatory Subunit

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NAE1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human, Mouse

Purification: Antigen Affinity Purified

Immunogen: Recombinant Human NEDD8-activating enzyme E1 regulatory subunit protein (1-220AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: WB:1:1000-1:5000, IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NAE1

Target: NAE1 (NEDD8 Activating Enzyme E1 Subunit 1 (NAE1))

Alternative Name: NAE1 (NAE1 Products)

Synonyms: APPBP1 antibody, CG7828 antibody, Dmel\\CG7828 antibody, anon-WO0140519.225 antibody, dAPP-BP1 antibody, dAPPBP1 antibody, A-116A10.1 antibody, ula-1 antibody, Appbp1 antibody, 59kDa antibody, appbp1 antibody, zgc:66148 antibody, beta-Amyloid precursor protein binding protein 1 antibody, NEDD8 activating enzyme E1 subunit 1 antibody, NEDD8 activating enzyme E1 subunit 1 S homeolog antibody, nedd8 activating enzyme E1 subunit 1 antibody, NEDD8-activating enzyme E1 regulatory subunit antibody, APP-BP1 antibody, NAE1 antibody, Nae1 antibody, nae1.S antibody, nae1 antibody, ula-1 antibody

Background:

Background: Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.

Aliases: 59 kDa antibody, A 116A10.1 antibody, Amyloid beta precursor protein binding protein 1 59kD antibody, Amyloid beta precursor protein binding protein 1 59 kDa antibody, Amyloid beta precursor protein binding protein 1 antibody, Amyloid beta precursor protein binding protein 1, 59 kDa antibody, Amyloid beta precursor protein-binding protein 1 antibody, Amyloid protein binding protein 1 antibody, Amyloid protein-binding protein 1 antibody, APP BP1 antibody, APP-BP1 antibody, APPBP 1 antibody, APPBP1 antibody, HPP 1 antibody, HPP1 antibody, NAE 1 antibody, NAE1 antibody, NEDD8 activating enzyme E1 regulatory subunit antibody, NEDD8 activating enzyme E1 subunit 1 antibody, NEDD8 activating enzyme E1 subunit antibody, NEDD8-activating enzyme E1 regulatory subunit antibody, Proto oncogene protein 1 antibody, Proto-oncogene protein 1 antibody, Protooncogene protein 1 antibody, ula 1 antibody, ULA1_HUMAN antibody

UniProt: Q13564