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NEDD8 Activating Enzyme E1 Subunit 1 Proteins (NAE1)

The protein encoded by NAE1 binds to the beta-amyloid precursor protein. Additionally we are shipping NAE1 Antibodies (98) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NAE1 8883 Q13564
Rat NAE1 NAE1 84019  
Mouse NAE1 NAE1 234664 Q8VBW6
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Top NAE1 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$498.21
Details
HOST_Escherichia coli (E. coli) Human His tag   10 μg Log in to see 1 to 2 Days
$443.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NAE1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,

Top referenced NAE1 Proteins

  1. Human NAE1 Protein expressed in Escherichia coli (E. coli) - ABIN668001 : Chen, McPhie, Hirschberg, Neve: The amyloid precursor protein-binding protein APP-BP1 drives the cell cycle through the S-M checkpoint and causes apoptosis in neurons. in The Journal of biological chemistry 2000 (PubMed)
    Show all 2 references for ABIN668001

More Proteins for NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) Interaction Partners

Fruit Fly (Drosophila melanogaster) NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) interaction partners

  1. Study shows that APP-BP1 specifically binds the intracellular domain of APP-like (show APP Proteins) protein (APPL (show APP Proteins)), APP-BP1 mutation partially suppresses the abnormal macrochaete phenotype of Appl (show APP Proteins)(d), while overexpression of dAPP-BP1 causes abnormal macrochaetes.

Human NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) interaction partners

  1. E1 (NAE1 and UBA3 (show UBA3 Proteins)) and E2 (UBC12 (show ube2m Proteins)) enzymes, as well as global NEDD8 (show NEDD8 Proteins) conjugation, were upregulated in over 2/3 of human intrahepatic cholangiocarcinoma

  2. analysis of a metal-based inhibitor of NEDD8 (show NEDD8 Proteins)-activating enzyme

  3. our results suggest that APP-BP1 modulates neuronal differentiation by altering gene expression profiles in fetal neural stem cells

  4. APP-BP1 plays an important role in the cell cycle progression of fetal neural stem cells

  5. APP-BP1 displayed decreased expression levels in HPV-positive head and neck squamous cell carcinoma

  6. structure and mutational analysis of human APPBP1-UBA3 (show UBA3 Proteins), the heterodimeric E1 enzyme (show ENOPH1 Proteins) for NEDD8 (show NEDD8 Proteins)

  7. Conservation in the mechanism of Nedd8 (show NEDD8 Proteins) activation by the human AppBp1-Uba3 (show UBA3 Proteins) heterodimer.

  8. Data report the structure of the quaternary complex between human APPBP1-UBA3 (show UBA3 Proteins), a heterodimeric E1, its ubl NEDD8 (show NEDD8 Proteins), and ATP.

  9. APP-BP1 is degraded by ubiquitin-dependent proteolysis.

Mouse (Murine) NEDD8 Activating Enzyme E1 Subunit 1 (NAE1) interaction partners

  1. APP-BP1 plays an important role in the cell cycle progression of fetal neural stem cells

NAE1 Protein Profile

Protein Summary

The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NAE1

  • beta-Amyloid precursor protein binding protein 1 (APP-BP1)
  • NEDD8 activating enzyme E1 subunit 1 (NAE1)
  • NEDD8 activating enzyme E1 subunit 1 (Nae1)
  • NEDD8 activating enzyme E1 subunit 1 (nae1)
  • nedd8 activating enzyme E1 subunit 1 (nae1)
  • Protein ULA-1 (ula-1)
  • 59kDa protein
  • A-116A10.1 protein
  • anon-WO0140519.225 protein
  • appbp1 protein
  • CG7828 protein
  • dAPP-BP1 protein
  • dAPPBP1 protein
  • Dmel\\CG7828 protein
  • ula-1 protein
  • zgc:66148 protein

Protein level used designations for NAE1

APP-BP1-PA , APP-BP1-PB , CG7828-PA , CG7828-PB , APP-BP1 , NEDD8-activating enzyme E1 regulatory subunit , NEDD8-activating enzyme E1 subunit , amyloid beta precursor protein binding protein 1, 59kDa , amyloid beta precursor protein-binding protein 1, 59 kDa , amyloid beta precursor protein-binding protein 1, 59kD , amyloid protein-binding protein 1 , proto-oncogene protein 1 , protooncogene protein 1 , APP-binding protein 1 , amyloid beta precursor protein binding protein 1

GENE ID SPECIES
39244 Drosophila melanogaster
8883 Homo sapiens
84019 Rattus norvegicus
234664 Mus musculus
415792 Gallus gallus
414612 Xenopus laevis
573336 Danio rerio
610026 Canis lupus familiaris
266650 Caenorhabditis elegans
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