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NAB2 encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. Additionally we are shipping NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) Antibodies (99) and NGFI-A Binding Protein 2 (EGR1 Binding Protein 2) Kits (3) and many more products for this protein.
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Data suggest that histone deacetylase (show HDAC1 Proteins) inhibitors inhibit the induction of NGF1A-binding protein (show NAB1 Proteins) Nab2 by brain derived neurotrophic factor (BDNF (show BDNF Proteins)), and thereby the relative induction of dopamine and cyclic AMP-regulated phosphoprotein (show ARPP21 Proteins), 32 kDa (DARPP-32 (show PPP1R1B Proteins)).
Nab2 is a novel endogenous negative regulator of Egr-1 (show EGR1 Proteins)-dependent TGF-beta (show TGFB1 Proteins) signaling responsible for setting the intensity of fibrotic responses
Nab1 and Nab2 proteins are necessary for Schwann cells to exit the cell cycle, downregulate suppressed cAMP-inducible protein (SCIP) expression and upregulate expression of critical myelination genes.
repression of the endogenous Rad gene by NAB2 involves interaction with the CHD4 (chromodomain helicase DNA-binding protein 4 (show CHD4 Proteins)) subunit of the NuRD (nucleosome remodeling and deacetylase) chromatin remodeling complex
NAB2 enhances IL-2 (show IL2 Proteins) transcription by acting as a coactivator for Egr-1 (show EGR1 Proteins).NAB2 is recruited to the Egr-1 (show EGR1 Proteins) binding site of the IL-2 (show IL2 Proteins) promoter.
We report here, that FGF23 (show FGF23 Proteins) induces not only Egr-1 (show EGR1 Proteins) but also two isoforms of NAB2, which are specific co-repressors of Egr-1 (show EGR1 Proteins).
The detection of nuclear relocation of STAT6 (show STAT6 Proteins) with immunohistochemistry is a characteristic of solitary fibrous tumours (SFTs), and may serve as a diagnostic marker that indicates NAB2-STAT6 (show STAT6 Proteins) fusion and helps to discriminate SFTs from histological mimics.
Variants of the NAB2-STAT6 (show STAT6 Proteins) fusion gene are found in solitary fibrous tumors of the meninges.
NAB2-STAT6 (show STAT6 Proteins) fusion is a diagnostic tumor marker for papillary' solitary fibrous tumor/hemangiopericytoma of brain.
the majority of intrathoracic SFTs exhibited STAT6 (show STAT6 Proteins) nuclear staining, and NAB2ex4-STAT6ex2/3 was the predominant fusion type.
Case Report: NAB2-STAT6 (show STAT6 Proteins) fusion in glioblastoma.
We delineate the common and rare NAB2-STAT6 (show STAT6 Proteins) fusion variants in solitary fibrous tumors
This study confirms that meningeal Meningeal solitary fibrous tumor and hemangiopericytoma represent a histopathologic continuum linked by STAT6 (show STAT6 Proteins) nuclear expression and NAB2-STAT6 (show STAT6 Proteins) fusion similar to their soft tissue counterparts.
This study validated the existence of the NAB2-STAT6 (show STAT6 Proteins) fusion gene in solitary fibrous tumors and examined its relation with pathological features.
also identified NAB2-STAT6 (show STAT6 Proteins) fusions in two hemangiopericytomas diagnosed in the past with a common variant of NAB2ex6-STAT6ex16/17
There was no association between solitary fibrous tumors with either NAB2 exon 4-STAT6 (show STAT6 Proteins) exon 2 or 3 fusion and tumors with other fusions regarding the frequency of mutations in the examined genes (P = .201).
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
NGFI-A binding protein 2 (EGR1 binding protein 2)
, EGR-1-binding protein 2
, NGFI-A binding protein 2 (EGR-1 binding protein 2)
, NGFI-A-binding protein 2
, EGR1 binding protein 2
, melanoma-associated delayed early response protein