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NIMA (Never in Mitosis Gene A)- Related Kinase 9 Proteins (NEK9)

Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Additionally we are shipping NIMA (Never in Mitosis Gene A)- Related Kinase 9 Antibodies (126) and NIMA (Never in Mitosis Gene A)- Related Kinase 9 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NEK9 217718 Q8K1R7
NEK9 91754 Q8TD19
Rat NEK9 NEK9 299204  
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Top NIMA (Never in Mitosis Gene A)- Related Kinase 9 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
$322.08
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NEK9 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
,

More Proteins for NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) Interaction Partners

Zebrafish NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) interaction partners

  1. requirement for Nek8 (show NEK8 Proteins) in left-right patterning is conserved

  2. Nek8 (show NEK8 Proteins) acts downstream of Inv (show INVS Proteins) function

  3. cross-species analysis between zebrafish and mouse demonstrates taht NEK8 (show NEK8 Proteins) has a role in development of pronephric cysts

Xenopus laevis NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) interaction partners

  1. Nercc1 contributes to both the centrosomal and the chromatin/Ran pathways that collaborate in the organization of a bipolar spindle

Mouse (Murine) NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) interaction partners

  1. NEK9 is a critical component of the replication stress response that promotes CHK1 (show CHEK1 Proteins) activity, maintaining genome integrity following challenges to DNA replication.

  2. Knockdown of Nek9 also impaired the spindle-pole localization of gamma-tubulin (show TUBG1 Proteins) and resulted in retention of the spindle assembly checkpoint protein Bub3 (show BUB3 Proteins) at the kinetochores.

Human NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) interaction partners

  1. Overall, these results highlight the complexity of virus-host interactions and identify a new role for the cellular protein Nek9 during human adenovirus infection, suggesting a role for Nek9 in regulating p53 (show TP53 Proteins) target gene expression.

  2. The C-terminal domain of Nek9 activates Nek7 (show NEK7 Proteins) through promoting back-to-back dimerization.

  3. The findings demonstrate that a novel NEK9 network regulates the growth of cancer cells lacking functional p53 (show TP53 Proteins).

  4. NEK9 inhibition represents a novel anti-cancer strategy by induction of mitotic catastrophe via impairment of spindle dynamics, cytokinesis and mitotic checkpoint (show BUB3 Proteins) control.

  5. Structural analysis of LC8 (show DYNLL1 Proteins) with both Nek9 peptides, together with different biophysical experiments, explains the observed diminished binding affinity of Nek9 to LC8 (show DYNLL1 Proteins) upon phosphorylation on Ser (show SIGLEC1 Proteins)(944) within the Nek9 sequence

  6. Nek9 phosphorylates NEDD1 (show NEDD1 Proteins) on Ser377 driving its recruitment and thereby that of gamma-tubulin (show TUBG1 Proteins) to the centrosome in mitotic cells.

  7. The interaction between the human NimA-like protein kinase (show CDK7 Proteins) Nek9 and the Helicobacter HcpC has been validated by ELISA and surface plasmon resonance.

  8. Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6 (show NEK6 Proteins)/7 and Eg5 (show KIF11 Proteins).

  9. DYNLL/LC8 (show DYNLL1 Proteins) protein controls signal transduction through the Nek9/Nek6 (show NEK6 Proteins) signaling module by regulating Nek6 (show NEK6 Proteins) binding to Nek9.

  10. binds the Ran GTPase (show RAN Proteins) and regulates mitotic progression

NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) Protein Profile

Protein Summary

Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (By similarity).

Gene names and symbols associated with NEK9

  • NIMA (never in mitosis gene a)- related kinase 9 (NEK9)
  • NIMA (never in mitosis gene a)-related kinase 8 (nek8)
  • NIMA (never in mitosis gene a)- related kinase 8 (nek8)
  • NIMA (never in mitosis gene a)- related kinase 8 (NEK8)
  • NIMA-related kinase 9 (nek9)
  • NIMA-related kinase 8 (LOC100345106)
  • NIMA (never in mitosis gene a)- related kinase 9 (nek9)
  • NIMA (never in mitosis gene a)-related expressed kinase 9 (Nek9)
  • NIMA-related kinase 9 (NEK9)
  • NIMA-related kinase 9 (Nek9)
  • C130021H08Rik protein
  • jck protein
  • MGC80499 protein
  • MGC88903 protein
  • Nek8 protein
  • NEK9 protein
  • nek12a protein
  • NERCC protein
  • NERCC1 protein
  • nphp9 protein

Protein level used designations for NEK9

serine/threonine-protein kinase Nek9 , NIMA-related kinase 8 , never in mitosis A-related kinase 8 , nimA-related protein kinase 8 , serine/threonine-protein kinase Nek8 , NIMA (never in mitosis gene a)- related kinase 8 , NIMA (never in mitosis gene a)- related kinase 9 , NIMA (never in mitosis gene a)-related expressed kinase 8 , serine/threonine-protein kinase Nek9-like , nercc1 kinase , never in mitosis A-related kinase 9 , nimA-related protein kinase 9 , NIMA-related kinase Nek8 , nimA-related kinase 8 , NIMA-family kinase Nercc1 , XNek9

GENE ID SPECIES
428891 Gallus gallus
534652 Bos taurus
100152772 Sus scrofa
171094 Danio rerio
448753 Xenopus (Silurana) tropicalis
455033 Pan troglodytes
701707 Macaca mulatta
779142 Xenopus laevis
100216232 Xenopus (Silurana) tropicalis
100345106 Oryctolagus cuniculus
100461917 Pongo abelii
100474361 Ailuropoda melanoleuca
100543466 Meleagris gallopavo
100556817 Anolis carolinensis
490790 Canis lupus familiaris
217718 Mus musculus
91754 Homo sapiens
299204 Rattus norvegicus
398600 Xenopus laevis
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