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NEK11 encodes a member of the never in mitosis gene A family of kinases. Additionally we are shipping NEK11 Antibodies (57) and many more products for this protein.
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Results show that downregulation of NEK11 in drug resistant cells might contribute to drug resistance in ovarian cancer.
NEK11 controls degradation of CDC25A by directly phosphorylating CDC25A on residues whose phosphorylation is required for beta-TrCP mediated CDC25A polyubiquitylation and degradation.
Nek11 has a role in the S-phase checkpoint downstream of the caffeine-sensitive pathway
Nucleolar Nek11 is a novel target of Nek2A (show NEK2 Proteins) in G1/S-arrested cells
NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint.
This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.
NIMA-related kinase 11
, never in mitosis A-related kinase 11
, nimA-related protein kinase 11
, serine/threonine-protein kinase Nek11
, NIMA (never in mitosis gene a)- related kinase 11
, NIMA (never in mitosis gene a)-related expressed kinase 11