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NKX3-1 encodes a homeobox-containing transcription factor. Additionally we are shipping NK3 Homeobox 1 Proteins (6) and NK3 Homeobox 1 Kits (1) and many more products for this protein.
Showing 10 out of 202 products:
Human Monoclonal NKX3-1 Primary Antibody for IF, WB - ABIN394023
Gurel, Ali, Montgomery, Begum, Hicks, Goggins, Eberhart, Clark, Bieberich, Epstein, De Marzo: NKX3.1 as a marker of prostatic origin in metastatic tumors. in The American journal of surgical pathology 2010
Show all 5 references for ABIN394023
Human Monoclonal NKX3-1 Primary Antibody for ELISA, WB - ABIN394230
Kim, Cheng, Hsu, Jin, Kader, Zheng, Isaacs, Xu, Sun: Prostate cancer risk-associated variants reported from genome-wide association studies: meta-analysis and their contribution to genetic Variation. in The Prostate 2010
Show all 5 references for ABIN394230
Human Monoclonal NKX3-1 Primary Antibody for FACS, IHC - ABIN969316
Jiang, Yu, Zhang, Chen, Liu, Hu, Zhang: p53 overexpression represses androgen-mediated induction of NKX3.1 in a prostate cancer cell line. in Experimental & molecular medicine 2007
Show all 4 references for ABIN969316
Cow (Bovine) Polyclonal NKX3-1 Primary Antibody for WB - ABIN2779438
Possner, Heuser, Kaulfuss, Scharf, Schulz, Hermann-Ringert, Thelen: Functional analysis of NKX3.1 in LNCaP prostate cancer cells by RNA interference. in International journal of oncology 2008
study demonstrated that expression of homeobox protein NK-3 homolog A(Nkx3.1) influenced both the timing and magnitude of the DNA damage response in the mouse prostate
Nkx3.1 loss and Tmprss2 (show TMPRSS2 Antibodies)-ERG (show ERG Antibodies) upregulation do not cooperate to enhance prostate tumorigenesis in vivo.
Id4 (show ID4 Antibodies) regulates NKX3.1, Sox9 (show SOX9 Antibodies) and PTEN (show PTEN Antibodies).
activated canonical Wnt (show WNT2 Antibodies) signals and Nkx3.1 function in a positive feedback loop to regulate prostate bud growth and luminal epithelial differentiation.
multiple NKX3.1 binding sites were found in the RAMP1 (show RAMP1 Antibodies) locus in human prostate cancer cells and in the normal mouse prostate.
Deletions of Klf5 (show KLF5 Antibodies) and Nkx3-1 do not have a additive effect in prostatic carcinogenesis in mouse model.
Transcriptional activation of prostate specific (show KLK3 Antibodies) homeobox (show PRRX1 Antibodies) gene NKX3-1 in subsets of T-cell lymphoblastic leukemia (T-ALL).
Androgen-dependent transcription of the mouse Nkx3.1 gene is conferred through a noncanonical element within the intron of the gene.
Nkx3.1 has a role in bacterial prostatitis and its progression to inflammation and neoplasia
Data indicated that all cells expressing MYC (show MYC Antibodies) in PIN (show DYNLL1 Antibodies) lesions showed marked reductions in Nkx3.1, implicating MYC (show MYC Antibodies) as a key factor that represses Nkx3.1 in PIN (show DYNLL1 Antibodies) lesions.
With deletion mutation analysis, plasmid construction, EMSA and oligonucleotide decoy technique, two Sp1 (show PSG1 Antibodies)-elements which located between +29 to +43 and -60 to -46 of NKX3.1 gene were identified and proven to be functional elements.
The androgen-regulated homeodomain transcription factor NKX3.1 plays roles in early prostate development and functions as a prostate-specific (show KLK3 Antibodies) tumor suppressor.
the association between the down-regulation of PTEN (show PTEN Antibodies) and NKX3.1 genes contributed to prostate tumorigenesis.
NKX3.1 and DYRK1B (show DYRK1B Antibodies) were shown to interact via the DYRK1B (show DYRK1B Antibodies) kinase domain. In vitro kinase assay showed that DYRK1B (show DYRK1B Antibodies) phosphorylated NKX3.1 at serine 185, a residue critical for NKX3.1 steady-state turnover.
An NKX3.1 binding site polymorphism in the l-plastin (show LCP1 Antibodies) promoter leads to differential gene expression in human prostate cancer
Analysis of prostate cancer tissues showed that the presence of a TMPRSS2 (show TMPRSS2 Antibodies)-ERG (show ERG Antibodies) rearrangement was highly correlated with lower levels of NKX3.1 expression consistent with the role of NKX3.1 as a suppressor of the pathogenic gene rearrangement.
NKX3.1 expression mediate beta-catenin (show CTNNB1 Antibodies) and E-cadherin (show CDH1 Antibodies) association and cell migration in prostate cells.
Our results indicate that variation in NKX3.1 expression combined with selenium or vitamin E treatment modifies the risk of prostate cancer.
NKX3.1 labelling is limited to estrogen/progesterone/androgen receptor (show AR Antibodies)-positive breast carcinomas.
This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene.
NK3 transcription factor related, locus 1
, NK3 homeobox 1
, Drosophila NK-3 transcription factor, locus 1
, homeobox protein NK-3 homolog A
, homeobox protein Nkx-3.1
, NK homeobox, family 3, A
, NK3 transcription factor homolog A
, NK-3 transcription factor, locus 1