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anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) Antibodies

NLRP3 encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. Additionally we are shipping NLRP3 Kits (8) and NLRP3 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NLRP3 114548 Q96P20
NLRP3 216799 Q8R4B8
NLRP3 287362  
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Top anti-NLRP3 Antibodies at antibodies-online.com

Showing 10 out of 205 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of NLRP3 Antibody (N-term) (ABIN652504) in MDA-MB231 cell line lysates (35 µg/lane).NLRP3 (arrow) was detected using the purified polyclonal antibody. NLRP3 Antibody (N-term) (ABIN652504) immunohistochemistry analysis in formalin fixed and paraffin embedded human lymph tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of NLRP3 Antibody (N-term) in MDA-MB231 cell line lysates (35ug/lane).NLRP3 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Goat Un-conjugated EIA, FACS AP22372PU-N NLRP3 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Peripheral Blood Leukocytes at 2.5 µg/ml using Biotinylated anti-Goat IgG secondary antibody, Alkaline Phosphatase-Streptavidin and chromogen. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Goat Un-conjugated IHC (p), IHC, ELISA Immunohistochemistry-Paraffin: NLRP3/NALP3 Antibody [ABIN2515774] - Human Tonsil shows focal and interstitial staining of the inflammatory elements close to the epithelia of the tonsil crypts. 0.1 mg Log in to see 5 to 7 Days
$408.19
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Antigen: 2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000;  TMB staining Read the data in Microplate Reader by 450nm. Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti Cryopyrin/CIAS1/NALP3 Polyclonal Antibody, Unconjugated (ABIN1386361) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$307.45
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$326.89
Details
Human Goat Un-conjugated IHC, ELISA, WB   100 μg Log in to see 4 to 5 Days
$326.89
Details
Human Rat Un-conjugated FACS, ICC, WB Detection of NLRP3/NALP3 in RAW 264.7 Mouse Cell Line by Flow Cytometry. RAW 264.7 mouse monocyte/macrophage cell line was stained with Rat Anti-Human/Mouse NLRP3/ NALP3 Monoclonal Antibody. To facilitate intracellular staining, cells were fixed with paraformaldehyde and permeabilized with saponin. NLRP3/NALP3 in RAW 264.7 Mouse Cell Line. NLRP3/NALP3 was detected in immersion fixed RAW 264.7 mouse monocyte/macrophage cell line using Rat Anti-Human/Mouse NLRP3/NALP3 Monoclonal Antibody. Specific staining was localized to cytoplasm. 100 μg Log in to see 6 to 7 Days
$345.19
Details
Human Mouse Un-conjugated IHC, IHC (fro), IHC (p), IP, WB Immunohistochemistry-Frozen: NLRP3/NALP3 Antibody (Nalpy3-b) [NBP1-97601] - Staining of endogenous NLRP3/NALP3 in epithelial layer of human tonsil (frozen section) using NLRP3/NALP3 (human), mAb (Nalpy3-b). Method: 5uM frozen section of tissue are dried and fixed with aceton. Tissue is washed with PBS and incubated with NLRP3/NALP3 (human), mAb (Nalpy3-b). 0.05 mg Log in to see 5 to 7 Days
$408.19
Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: NLRP3/NALP3 Antibody [NBP1-90207] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp Immunohistochemistry-Paraffin: NLRP3/NALP3 Antibody [NBP1-90207] - NALP3 Antibody [NBP1-90207] - Staining of human stomach shows strong cytoplasmic and nuclear positivity in glandular cells. 0.1 mL Log in to see 12 to 15 Days
$439.69
Details

NLRP3 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-NLRP3 Antibodies

  1. Human Monoclonal NLRP3 Primary Antibody for FACS, ICC - ABIN4898963 : Hu, Zhang, Wang, Mao, Lv, Yuan, Huang, Ding, Xie, Liu: Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue light. in Cell death & disease 2016 (PubMed)
    Show all 6 references for ABIN4898963

  2. Human Polyclonal NLRP3 Primary Antibody for IHC, IHC (p) - ABIN4340115 : Abdul-Sater, Koo, Häcker, Ojcius: Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis. in The Journal of biological chemistry 2009 (PubMed)
    Show all 5 references for ABIN4340115

  3. Human Polyclonal NLRP3 Primary Antibody for IF (p), IHC (p) - ABIN1386361 : Zendedel, Johann, Mehrabi, Joghataei, Hassanzadeh, Kipp, Beyer: Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model. in Molecular neurobiology 2015 (PubMed)
    Show all 4 references for ABIN1386361

  4. Human Monoclonal NLRP3 Primary Antibody for IHC, IHC (fro) - ABIN4340117 : Shio, Tiemi Shio, Eisenbarth, Savaria, Vinet, Bellemare, Harder, Sutterwala, Bohle, Descoteaux, Flavell, Olivier: Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. in PLoS pathogens 2009 (PubMed)
    Show all 3 references for ABIN4340117

  5. Human Polyclonal NLRP3 Primary Antibody for IHC (p), IHC - ABIN251577 : Wei, Chen, James, Stone, Chamley: IL-1 beta but not the NALP3 inflammasome is an important determinant of endothelial cell responses to necrotic/dangerous trophoblastic debris. in Placenta 2015 (PubMed)
    Show all 2 references for ABIN251577

  6. Human Polyclonal NLRP3 Primary Antibody for IHC (p), WB - ABIN652504 : Jhang, Lu, Ho, Cheng, Yen: Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation. in Journal of agricultural and food chemistry 2015 (PubMed)
    Show all 2 references for ABIN652504

  7. Human Polyclonal NLRP3 Primary Antibody for EIA, WB - ABIN453768 : Feldmann, Prieur, Quartier, Berquin, Certain, Cortis, Teillac-Hamel, Fischer, de Saint Basile: Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. in American journal of human genetics 2002 (PubMed)

  8. Human Polyclonal NLRP3 Primary Antibody for ELISA, WB - ABIN184887 : Hoffman, Mueller, Broide, Wanderer, Kolodner: Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. in Nature genetics 2001 (PubMed)

  9. Human Polyclonal NLRP3 Primary Antibody for IHC, ELISA - ABIN185676 : Kanneganti, Ozören, Body-Malapel, Amer, Park, Franchi, Whitfield, Barchet, Colonna, Vandenabeele, Bertin, Coyle, Grant, Akira, Núñez: Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. in Nature 2006 (PubMed)

More Antibodies against NLRP3 Interaction Partners

Human NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. NLRP3 inflammasome is implicated in the pathogenesis of dermatomyositis and polymyositis.

  2. these data show that NLRP3 is primarily a kidney tubule-expressed protein that decreases in abundance in progressive IgAN.

  3. Studies indicate that NIMA related kinase 7 (NEK7 (show NEK7 Antibodies)) targets at NLRP3 protein and involves in the activation of NLRP3 inflammasome.

  4. This study demonstrated that dysregulated expression of NLRP3-caspase-1 (show CASP1 Antibodies)-IL-1beta (show IL1B Antibodies) axis was observed in patients with MM, suggesting they might be involved in the pathogenesis of MM.

  5. DNA methylation (show HELLS Antibodies) was involved in NLRP3 inflammasome activation during Mycobacterium tuberculosis infection and provided a new insight into the relationship between host and pathogens.

  6. The NLRP3/caspase-1 (show CASP1 Antibodies)/IL-1beta (show IL1B Antibodies) axis is active in cartilaginous endplates of patients with Modic changes and inflammatory cascades can exacerbate the cartilaginous endplate degeneration which may act as a trigger for intervertebral disc degeneration and low back pain.

  7. Authors conclude that Aldo induces renal tubular cell injury via MR dependent, mitochondrial ROS (show ROS1 Antibodies)-mediated NLRP3 inflammasome activation.

  8. None of these 15 SNPs in NOD2 (show NOD2 Antibodies), CARD8 (show CARD8 Antibodies), and NLPR3 genes showed a significant difference.

  9. NLRP3 (rs4612666) single-nucleotide polymorphisms with ageing and/or smoking habit potentially might play a significant role in the pathogenic pathways of periodontal disease.

  10. Levels of NLRP3 and IL1beta (show IL1B Antibodies) were positively correlated with adipocyte diameter in male, but not in female cancer patients.

Mouse (Murine) NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. Data show that inhibiting caspase-1 (show CASP1 Antibodies) activity in the NLR (show CXCR5 Antibodies) family, pyrin domain-containing 3 protein (NLRP3) inflammasome decreased gastric cell apoptosis.

  2. Authors conclude that Aldo induces renal tubular cell injury via MR dependent, mitochondrial ROS (show ROS1 Antibodies)-mediated NLRP3 inflammasome activation.

  3. Using genetically modified mice lacking either NLRP3 or multiple downstream inflammasome response elements, we ruled out a role for the NLRP3 inflammasome or any Caspase-1 (show CASP1 Antibodies) or -11 dependent inflammasome in regulating RBC (show CACNA1C Antibodies) alloantibody production to a model antigen.

  4. Decreased ET-1 (show EDN1 Antibodies) levels were associated with greater activation of NLRP3 and IL-1beta (show IL1B Antibodies) in normal glucose. High glucose increased NLRP3 markers and activation compared to normal and low glucose

  5. Ambient fine particulate matter-induced myocarditis is mediated by EGFR (show EGFR Antibodies)/Akt (show AKT1 Antibodies) signaling and overexpression of NLRP3 and NLRP12 (show NLRP12 Antibodies).

  6. Hepatic NLRP3 inflammasome activation played an important role in the development of non-alcoholic fatty liver disease via relA (show NFkBP65 Antibodies) phosphorylation.

  7. NMDAR1 (show GRIN1 Antibodies) plays a pivotal role in hemin-induced NLRP3-mediated inflammatory damage through synergistic activation.

  8. Renal medullary Nlrp3 inflammasomes regulate renal medullary blood flow and sodium excretion.

  9. our study demonstrated that ablating the NLRP3 gene significantly reduced neuroinflammation and delayed RGC loss after optic nerve crush injury.

  10. Data show that NLR family pyrin domain containing 3 (Nlrp3) gene silencing abolished the visfatin (show NAMPT Antibodies)-induced high mobility group box (show SSRP1 Antibodies) protein 1 (HMGB1 (show HMGB1 Antibodies)) release from vascular endothelial cell (MVEC).

NLRP3 Antigen Profile

Protein Summary

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Gene names and symbols associated with NLRP3

  • NLR family, pyrin domain containing 3 (NLRP3) antibody
  • NLR family, pyrin domain containing 3 (LOC100351623) antibody
  • NLR family, pyrin domain containing 3 (nlrp3) antibody
  • NLR family, pyrin domain containing 3 (Nlrp3) antibody
  • AGTAVPRL antibody
  • AII antibody
  • AII/AVP antibody
  • AVP antibody
  • C1orf7 antibody
  • Cias1 antibody
  • CLR1.1 antibody
  • FCAS antibody
  • FCU antibody
  • Mmig1 antibody
  • MWS antibody
  • NALP3 antibody
  • Pypaf1 antibody

Protein level used designations for NLRP3

NACHT, LRR and PYD domains-containing protein 3 , cold autoinflammatory syndrome 1 , cryopyrin , NLR family, pyrin domain containing 3 , NACHT, LRR and PYD domains-containing protein 3-like , NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3 , NACHT, LRR and PYD containing protein 3 , PYRIN-containing APAF1-like protein 1 , caterpiller protein 1.1 , cold autoinflammatory syndrome 1 protein , nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 , NACHT/LRR/pyrin domain-containing protein 3 , cold autoinflammatory syndrome 1 homolog , cold autoinflammatory syndrome 1 protein homolog , mast cell maturation inducible protein 1 , mast cell maturation-associated-inducible protein 1 , NLR family pyrin domain containing 3

GENE ID SPECIES
423021 Gallus gallus
469743 Pan troglodytes
490576 Canis lupus familiaris
100351623 Oryctolagus cuniculus
100381165 Xenopus laevis
100392399 Callithrix jacchus
114548 Homo sapiens
216799 Mus musculus
538639 Bos taurus
287362 Rattus norvegicus
701278 Macaca mulatta
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