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anti-NLR Family, Pyrin Domain Containing 3 (NLRP3) Antibodies

NLRP3 encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. Additionally we are shipping NLRP3 Kits (6) and NLRP3 Proteins (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NLRP3 114548 Q96P20
NLRP3 216799 Q8R4B8
NLRP3 287362  
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Top anti-NLRP3 Antibodies at antibodies-online.com

Showing 10 out of 196 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of NLRP3 Antibody (N-term) (ABIN652504) in MDA-MB231 cell line lysates (35 µg/lane).NLRP3 (arrow) was detected using the purified polyclonal antibody. NLRP3 Antibody (N-term) (ABIN652504) immunohistochemistry analysis in formalin fixed and paraffin embedded human lymph tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of NLRP3 Antibody (N-term) in MDA-MB231 cell line lysates (35ug/lane).NLRP3 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Cow Goat Un-conjugated EIA, FACS AP22372PU-N NLRP3 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Peripheral Blood Leukocytes at 2.5 µg/ml using Biotinylated anti-Goat IgG secondary antibody, Alkaline Phosphatase-Streptavidin and chromogen. 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Antigen: 2 µg/100 µL  Primary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000;  Secondary: HRP conjugated Rabbit Anti-Goat IgG at 1: 5000;  TMB staining Read the data in Microplate Reader by 450nm. Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti Cryopyrin/CIAS1/NALP3 Polyclonal Antibody, Unconjugated (ABIN1386361) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details
Human Goat Un-conjugated ELISA, WB   100 μg Log in to see 4 to 5 Days
$326.89
Details
Human Goat Un-conjugated IHC, ELISA, WB   100 μg Log in to see 4 to 5 Days
$326.89
Details
Human Rabbit Un-conjugated ICC, IF, IHC (p), WB Immunohistochemical staining of rat skin tissue using Cryopyrin antibody (dilution of primary antibody - 1:200) IHC-P staining of human  thyroid carcinoma tissue using anti-Cryopyrin (dilution at 1:200) 100 μg Log in to see 9 to 14 Days
$351.12
Details
Human Rabbit Un-conjugated IHC (p), WB Anti-CIAS1/NALP3 antibody, IHC(P) IHC(P): Human Tonsil Tissue Anti-CIAS1/NALP3 antibody, Western blotting Lane 1: HEP-2 Cell Lysate Lane 2: A549 Cell Lysate Lane 3: U87 Cell Lysate Lane 4: CEM Cell Lysate 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated WB Observed bind size: 118KD Anti-CIAS1/NALP3 Picoband antibody,  All lanes: Anti CIAS1  at 0.5ug/ml WB: Recombinant Human CIAS1 Protein 0.5ng Predicted bind size: 37KD Observed bind size: 37KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details

NLRP3 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-NLRP3 Antibodies

  1. Human Polyclonal NLRP3 Primary Antibody for IF (p), IHC (p) - ABIN1386361 : Zendedel, Johann, Mehrabi, Joghataei, Hassanzadeh, Kipp, Beyer: Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model. in Molecular neurobiology 2015 (PubMed)
    Show all 4 references for ABIN1386361

  2. Human Polyclonal NLRP3 Primary Antibody for ICC, IF - ABIN2506713 : Saitoh, Tsutsumi, Tada, Ikeda, Noguchi: Recurrent primary leptomeningeal astrocytoma of the lumbosacral spinal cord resembling schwannoma. A case report. in Acta pathologica japonica 1989 (PubMed)
    Show all 2 references for ABIN2506713

  3. Human Polyclonal NLRP3 Primary Antibody for IHC (p), WB - ABIN652504 : Jhang, Lu, Ho, Cheng, Yen: Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation. in Journal of agricultural and food chemistry 2015 (PubMed)
    Show all 2 references for ABIN652504

  4. Human Polyclonal NLRP3 Primary Antibody for IHC, ELISA - ABIN185676 : Kanneganti, Ozören, Body-Malapel, Amer, Park, Franchi, Whitfield, Barchet, Colonna, Vandenabeele, Bertin, Coyle, Grant, Akira, Núñez: Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. in Nature 2006 (PubMed)

  5. Human Polyclonal NLRP3 Primary Antibody for ELISA, WB - ABIN184887 : Hoffman, Mueller, Broide, Wanderer, Kolodner: Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. in Nature genetics 2001 (PubMed)

  6. Human Polyclonal NLRP3 Primary Antibody for EIA, WB - ABIN453768 : Feldmann, Prieur, Quartier, Berquin, Certain, Cortis, Teillac-Hamel, Fischer, de Saint Basile: Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. in American journal of human genetics 2002 (PubMed)

More Antibodies against NLRP3 Interaction Partners

Human NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. NLRP3 (rs4612666) single-nucleotide polymorphisms with ageing and/or smoking habit potentially might play a significant role in the pathogenic pathways of periodontal disease.

  2. Levels of NLRP3 and IL1beta (show IL1B Antibodies) were positively correlated with adipocyte diameter in male, but not in female cancer patients.

  3. High expression of NLRP3, NLRC4 (show NLRC4 Antibodies), and CASP1 (show CASP1 Antibodies) in background non-tumorous liver is significantly correlated with poor prognosis of patients after resection of hepatocellular carcinoma.

  4. identical amino acid substitutions related to NLRP3 mutations are known to be sometimes associated with different phenotype suggesting the involvement of additional genetic and environmental factors

  5. Results indicate that NLRP3 inflammasome plays a vital role in regulating the proliferation and migration of A549 lung cancer cells.

  6. Our findings for the first time show that the NLRP3 rs10754558 polymorphism is involved in the occurrence of CAD (show CAD Antibodies) in the Chinese Han population; and G allele can effectively predict clinical outcome of CAD (show CAD Antibodies). The G allele susceptibility to CAD (show CAD Antibodies) is maybe associated with the increased level of serum IL-1b (show IL1B Antibodies).

  7. We now show that ADAM10 (show ADAM10 Antibodies) is critical for alpha-hemolysin (show PLC Antibodies)-mediated activation of the NLRP3 inflammasome in human monocytes as siRNA knockdown or chemical blockade of ADAM10 (show ADAM10 Antibodies)-alpha-hemolysin (show PLC Antibodies) interaction leads to diminished inflammasome activation and cell death by reducing the available ADAM10 (show ADAM10 Antibodies) on the cell surface.

  8. There is a significant association between rs3806268 in NLRP3 gene and the risk of primary gout in a Chinese population.

  9. the NLRP3 inflammasome is dysregulated in idiopathic pulmonary fibrosis but not in rheumatoid arthritis-usual interstitial pneumonia

  10. The NLRP3 rs3806265 T allele was significantly more frequent in the patients with RAS than in the healthy controls.

Mouse (Murine) NLR Family, Pyrin Domain Containing 3 (NLRP3) interaction partners

  1. Ambient fine particulate matter-induced myocarditis is mediated by EGFR (show EGFR Antibodies)/Akt (show AKT1 Antibodies) signaling and overexpression of NLRP3 and NLRP12 (show NLRP12 Antibodies).

  2. Hepatic NLRP3 inflammasome activation played an important role in the development of non-alcoholic fatty liver disease via relA (show NFkBP65 Antibodies) phosphorylation.

  3. NMDAR1 (show GRIN1 Antibodies) plays a pivotal role in hemin-induced NLRP3-mediated inflammatory damage through synergistic activation.

  4. Renal medullary Nlrp3 inflammasomes regulate renal medullary blood flow and sodium excretion.

  5. our study demonstrated that ablating the NLRP3 gene significantly reduced neuroinflammation and delayed RGC loss after optic nerve crush injury.

  6. Data show that NLR family pyrin domain containing 3 (Nlrp3) gene silencing abolished the visfatin (show NAMPT Antibodies)-induced high mobility group box (show SSRP1 Antibodies) protein 1 (HMGB1 (show HMGB1 Antibodies)) release from vascular endothelial cell (MVEC).

  7. Sertoli cells have a functional NALP3 inflammasome that modulates NOD1 (show NOD1 Antibodies) and pro-IL-1beta (show IL1B Antibodies) expression, while NOD2 (show NOD2 Antibodies) inversely promoted IL-1beta (show IL1B Antibodies) expression.

  8. Melatonin also attenuated the expressions of NLRP3, apoptosis-associated speck-like protein containing a caspase (show CASP3 Antibodies) recruitment domain (ASC (show STS Antibodies)), cleaved caspase-1 (show CASP1 Antibodies), interleukin-1beta (IL-1beta (show IL1B Antibodies)), and interleukin-6 (IL-6 (show IL6 Antibodies)); these changes were also associated with an increase in the anti-apoptotic factor (Bcl2 (show BCL2 Antibodies)) and reduction in the pro-apoptotic factor (Bim (show BCL2L11 Antibodies)).

  9. Poly-ADP-ribosylation-mediated degradation of ARTD1 (show PARP1 Antibodies) by the NLRP3 inflammasome is a prerequisite for osteoclast maturation.

  10. provides a direct link between miR-7 (show LILRB1 Antibodies) and NLRP3 inflammasome-mediated neuroinflammation in the pathogenesis of Parkinson's disease

NLRP3 Antigen Profile

Protein Summary

This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.

Gene names and symbols associated with NLRP3

  • NLR family, pyrin domain containing 3 (NLRP3) antibody
  • NLR family, pyrin domain containing 3 (LOC100351623) antibody
  • NLR family, pyrin domain containing 3 (nlrp3) antibody
  • NLR family, pyrin domain containing 3 (Nlrp3) antibody
  • AGTAVPRL antibody
  • AII antibody
  • AII/AVP antibody
  • AVP antibody
  • C1orf7 antibody
  • Cias1 antibody
  • CLR1.1 antibody
  • FCAS antibody
  • FCU antibody
  • Mmig1 antibody
  • MWS antibody
  • NALP3 antibody
  • Pypaf1 antibody

Protein level used designations for NLRP3

NACHT, LRR and PYD domains-containing protein 3 , cold autoinflammatory syndrome 1 , cryopyrin , NLR family, pyrin domain containing 3 , NACHT, LRR and PYD domains-containing protein 3-like , NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3 , NACHT, LRR and PYD containing protein 3 , PYRIN-containing APAF1-like protein 1 , caterpiller protein 1.1 , cold autoinflammatory syndrome 1 protein , nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3 , NACHT/LRR/pyrin domain-containing protein 3 , cold autoinflammatory syndrome 1 homolog , cold autoinflammatory syndrome 1 protein homolog , mast cell maturation inducible protein 1 , mast cell maturation-associated-inducible protein 1 , NLR family pyrin domain containing 3

GENE ID SPECIES
423021 Gallus gallus
469743 Pan troglodytes
490576 Canis lupus familiaris
100351623 Oryctolagus cuniculus
100381165 Xenopus laevis
100392399 Callithrix jacchus
114548 Homo sapiens
216799 Mus musculus
538639 Bos taurus
287362 Rattus norvegicus
701278 Macaca mulatta
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