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NLRP3 encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. Additionally we are shipping NLRP3 Kits (8) and NLRP3 Proteins (4) and many more products for this protein.
Showing 10 out of 205 products:
Human Monoclonal NLRP3 Primary Antibody for FACS, ICC - ABIN4898963
Hu, Zhang, Wang, Mao, Lv, Yuan, Huang, Ding, Xie, Liu: Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue light. in Cell death & disease 2016
Show all 6 references for ABIN4898963
Human Polyclonal NLRP3 Primary Antibody for IHC, IHC (p) - ABIN4340115
Abdul-Sater, Koo, Häcker, Ojcius: Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis. in The Journal of biological chemistry 2009
Show all 5 references for ABIN4340115
Human Polyclonal NLRP3 Primary Antibody for IF (p), IHC (p) - ABIN1386361
Zendedel, Johann, Mehrabi, Joghataei, Hassanzadeh, Kipp, Beyer: Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model. in Molecular neurobiology 2015
Show all 4 references for ABIN1386361
Human Monoclonal NLRP3 Primary Antibody for IHC, IHC (fro) - ABIN4340117
Shio, Tiemi Shio, Eisenbarth, Savaria, Vinet, Bellemare, Harder, Sutterwala, Bohle, Descoteaux, Flavell, Olivier: Malarial hemozoin activates the NLRP3 inflammasome through Lyn and Syk kinases. in PLoS pathogens 2009
Show all 3 references for ABIN4340117
Human Polyclonal NLRP3 Primary Antibody for IHC (p), IHC - ABIN251577
Wei, Chen, James, Stone, Chamley: IL-1 beta but not the NALP3 inflammasome is an important determinant of endothelial cell responses to necrotic/dangerous trophoblastic debris. in Placenta 2015
Show all 2 references for ABIN251577
Human Polyclonal NLRP3 Primary Antibody for IHC (p), WB - ABIN652504
Jhang, Lu, Ho, Cheng, Yen: Protective Effects of Catechin against Monosodium Urate-Induced Inflammation through the Modulation of NLRP3 Inflammasome Activation. in Journal of agricultural and food chemistry 2015
Show all 2 references for ABIN652504
Human Polyclonal NLRP3 Primary Antibody for EIA, WB - ABIN453768
Feldmann, Prieur, Quartier, Berquin, Certain, Cortis, Teillac-Hamel, Fischer, de Saint Basile: Chronic infantile neurological cutaneous and articular syndrome is caused by mutations in CIAS1, a gene highly expressed in polymorphonuclear cells and chondrocytes. in American journal of human genetics 2002
Human Polyclonal NLRP3 Primary Antibody for ELISA, WB - ABIN184887
Hoffman, Mueller, Broide, Wanderer, Kolodner: Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. in Nature genetics 2001
Human Polyclonal NLRP3 Primary Antibody for IHC, ELISA - ABIN185676
Kanneganti, Ozören, Body-Malapel, Amer, Park, Franchi, Whitfield, Barchet, Colonna, Vandenabeele, Bertin, Coyle, Grant, Akira, Núñez: Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. in Nature 2006
NLRP3 inflammasome is implicated in the pathogenesis of dermatomyositis and polymyositis.
these data show that NLRP3 is primarily a kidney tubule-expressed protein that decreases in abundance in progressive IgAN.
Studies indicate that NIMA related kinase 7 (NEK7 (show NEK7 Antibodies)) targets at NLRP3 protein and involves in the activation of NLRP3 inflammasome.
This study demonstrated that dysregulated expression of NLRP3-caspase-1 (show CASP1 Antibodies)-IL-1beta (show IL1B Antibodies) axis was observed in patients with MM, suggesting they might be involved in the pathogenesis of MM.
DNA methylation (show HELLS Antibodies) was involved in NLRP3 inflammasome activation during Mycobacterium tuberculosis infection and provided a new insight into the relationship between host and pathogens.
The NLRP3/caspase-1 (show CASP1 Antibodies)/IL-1beta (show IL1B Antibodies) axis is active in cartilaginous endplates of patients with Modic changes and inflammatory cascades can exacerbate the cartilaginous endplate degeneration which may act as a trigger for intervertebral disc degeneration and low back pain.
Authors conclude that Aldo induces renal tubular cell injury via MR dependent, mitochondrial ROS (show ROS1 Antibodies)-mediated NLRP3 inflammasome activation.
None of these 15 SNPs in NOD2 (show NOD2 Antibodies), CARD8 (show CARD8 Antibodies), and NLPR3 genes showed a significant difference.
NLRP3 (rs4612666) single-nucleotide polymorphisms with ageing and/or smoking habit potentially might play a significant role in the pathogenic pathways of periodontal disease.
Levels of NLRP3 and IL1beta (show IL1B Antibodies) were positively correlated with adipocyte diameter in male, but not in female cancer patients.
Data show that inhibiting caspase-1 (show CASP1 Antibodies) activity in the NLR (show CXCR5 Antibodies) family, pyrin domain-containing 3 protein (NLRP3) inflammasome decreased gastric cell apoptosis.
Using genetically modified mice lacking either NLRP3 or multiple downstream inflammasome response elements, we ruled out a role for the NLRP3 inflammasome or any Caspase-1 (show CASP1 Antibodies) or -11 dependent inflammasome in regulating RBC (show CACNA1C Antibodies) alloantibody production to a model antigen.
Decreased ET-1 (show EDN1 Antibodies) levels were associated with greater activation of NLRP3 and IL-1beta (show IL1B Antibodies) in normal glucose. High glucose increased NLRP3 markers and activation compared to normal and low glucose
Ambient fine particulate matter-induced myocarditis is mediated by EGFR (show EGFR Antibodies)/Akt (show AKT1 Antibodies) signaling and overexpression of NLRP3 and NLRP12 (show NLRP12 Antibodies).
Hepatic NLRP3 inflammasome activation played an important role in the development of non-alcoholic fatty liver disease via relA (show NFkBP65 Antibodies) phosphorylation.
NMDAR1 (show GRIN1 Antibodies) plays a pivotal role in hemin-induced NLRP3-mediated inflammatory damage through synergistic activation.
Renal medullary Nlrp3 inflammasomes regulate renal medullary blood flow and sodium excretion.
our study demonstrated that ablating the NLRP3 gene significantly reduced neuroinflammation and delayed RGC loss after optic nerve crush injury.
Data show that NLR family pyrin domain containing 3 (Nlrp3) gene silencing abolished the visfatin (show NAMPT Antibodies)-induced high mobility group box (show SSRP1 Antibodies) protein 1 (HMGB1 (show HMGB1 Antibodies)) release from vascular endothelial cell (MVEC).
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NALP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, and neonatal-onset multisystem inflammatory disease (NOMID). Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data\; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid.
NACHT, LRR and PYD domains-containing protein 3
, cold autoinflammatory syndrome 1
, NLR family, pyrin domain containing 3
, NACHT, LRR and PYD domains-containing protein 3-like
, NACHT domain-, leucine-rich repeat-, and PYD-containing protein 3
, NACHT, LRR and PYD containing protein 3
, PYRIN-containing APAF1-like protein 1
, caterpiller protein 1.1
, cold autoinflammatory syndrome 1 protein
, nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 3
, NACHT/LRR/pyrin domain-containing protein 3
, cold autoinflammatory syndrome 1 homolog
, cold autoinflammatory syndrome 1 protein homolog
, mast cell maturation inducible protein 1
, mast cell maturation-associated-inducible protein 1
, NLR family pyrin domain containing 3