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NSUN2 encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. Additionally we are shipping NSUN2 Antibodies (41) and many more products for this protein.
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study identified NSun2 as a novel component of the chromatoid body and show that NSun2 is essential for germ cell differentiation in the testis
Steady-state levels of unmethylated tRNAs were substantially reduced, and loss of Dnmt2 (show TRDMT1 Proteins) and NSun2 was further associated with reduced rates of overall protein synthesis.
NSUN2 localizes to the nucleolus of Purkinje cells in the cerebellum. Mutation to arginine at residue 679 causes NSUN2 to fail to localize within the nucleolus.
we identify that an RNA methyltransferase (Misu/Nsun2) is required to balance stem cell self-renewal and differentiation in skin
Misu is a novel downstream Myc (show MYC Proteins) target that methylates RNA polymerase III transcripts. Misu mediates Myc (show MYC Proteins)-induced cell proliferation and growth and is a potential target for cancer therapies.
These results suggest a novel mechanism by which c-Myc promotes proliferation by stabilizing the mitotic spindle in fast-dividing cells via Misu and NuSAP.
Our findings provide a unique insight into the roles and effects of NSUN2 overexpression in breast cancer cells
findings point to YB-1 (show YBX1 Proteins) and NSUN2 as possible mediators of the process of transfer of specific mRNAs into exosomes, allowing us to speculate on an involvement of these proteins in the mRNA sorting via the recognition of the above motifs
These findings indicate that NSun2-mediated mRNA methylation regulates p27 (show PAK2 Proteins) and CDK1 (show CDK1 Proteins) levels during replicative senescence.
A novel homozygous variant c.1020delA in NSUN2 gene segregated in an autosomal recessive mode in the family of a child with intellectual disability. It causes a frameshift and premature stop codon, decreasing mRNA levels.
By methylating the CDK1 (show CDK1 Proteins) mRNA at the 3'UTR, NSun2 enhances the translation of CDK1 (show CDK1 Proteins), thereby influencing entry into and the progression of the cell division cycle.
tRNA modifying enzymes, NSUN2 and METTL1 (show METTL1 Proteins), determine sensitivity to 5-fluorouracil in HeLa cells
Report frequencies of short tandem repeat markers linked to TUSC3 (MRT7 (show TUSC3 Proteins)) or NSUN2 (MRT5) genes used for homozygosity mapping of recessive intellectual disability.
Results show that NSun2 methylates primary (pri-miR (show MLXIP Proteins)-125b), precursor (pre-miR (show MLXIP Proteins)-125b), and mature microRNA 125b (miR (show MLXIP Proteins)-125b) in vitro and in vivo.
In conclusion, failure in NSun2-mediated tRNA methylation contributes to human diseases via stress-induced RNA cleavage.
Impaired processing of vault ncRNA may contribute to the etiology of NSun2-deficiency human disorders.
This gene encodes a methyltransferase that catalyzes the methylation of cytosine to 5-methylcytosine (m5C) at position 34 of intron-containing tRNA(Leu)(CAA) precursors. This modification is necessary to stabilize the anticodon-codon pairing and correctly translate the mRNA. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Myc-induced SUN domain containing protein
, NOL1/NOP2/Sun domain family 2
, myc-induced SUN domain-containing protein
, tRNA (cytosine(34)-C(5))-methyltransferase
, tRNA (cytosine-5-)-methyltransferase NSUN2
, NOL1/NOP2/Sun domain family, member 2
, NOP2/Sun domain family, member 2
, 5-methycytoisine methyltransferase
, Myc-induced SUN-domain-containing protein
, NOL1/NOP2/Sun domain family member 2
, substrate of AIM1/Aurora kinase B
, tRNA methyltransferase 4 homolog