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Nephronectin Proteins (NPNT)

Functional ligand of integrin alpha-8/beta-1 in kidney development. Additionally we are shipping Nephronectin Antibodies (36) and Nephronectin Kits (8) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NPNT 114249 Q91V88
NPNT 255743 Q6UXI9
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Top Nephronectin Proteins at antibodies-online.com

Showing 4 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 11 to 13 Days
$739.20
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$920.54
Details

NPNT Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human
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More Proteins for Nephronectin (NPNT) Interaction Partners

Zebrafish Nephronectin (NPNT) interaction partners

  1. Morpholino-mediated knockdown of Npnt prevents proper heart valve leaflet formation and trabeculation and results in greater than 85% lethality at 7 days post-fertilization.

Mouse (Murine) Nephronectin (NPNT) interaction partners

  1. Nephronectin is capable of binding to heparan sulfate proteoglycans in basement membranes via the MAM domain.

  2. These results indicate that Npnt plays an important role in the initiation of hepatitis by recruiting CD4 (show CD4 Proteins)(+) T cells or NKT (show CTSL1 Proteins) cells into the foci of inflammation.

  3. canonical TGF-b signaling through Smad2 (show SMAD2 Proteins) regulates Npnt geneexpression in osteoblasts.

  4. expression of a fragment containing the 3'-untranslated region (3'-UTR) of nephronectin in osteoblast progenitor cells MC3T3-E1 promoted cell differentiation

  5. These results suggest that TNF-alpha (show TNF Proteins) inhibits POEM expression through the NF-kappaB (show NFKB1 Proteins) signaling pathway and down-regulation of POEM influences the inhibition of osteoblast differentiation by TNF-alpha (show TNF Proteins).

  6. TGF-beta (show TGFB1 Proteins) inhibited differentiation of osteoblasts transfected with various truncated Npnt constructs, suggesting that TGF-beta (show TGFB1 Proteins) can exert a down-stream effect on Npnt function.

  7. MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7

  8. it was demonstrated that nephronectin promotes differentiation during osteoblast differentiation and the EGF (show EGF Proteins)-like repeats were essential.

  9. results thus place nephronectin and alpha8beta1 integrin in a pathway that regulates Gdnf (show GDNF Proteins) expression and is essential for kidney development

  10. deregulation of Nephronectin expression plays a role in the development or progression of malignant melanoma.

Human Nephronectin (NPNT) interaction partners

  1. The expression of nephronectin was sufficient to discriminate DN from other kidney diseases with mesangial matrix expansion and nodular lesions.

  2. Nephronectin is associated with the development of diabetic glomerulosclerosis.

  3. MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7

Nephronectin (NPNT) Protein Profile

Protein Summary

Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).

Gene names and symbols associated with Nephronectin Proteins (NPNT)

  • nephronectin (NPNT)
  • nephronectin (npnt)
  • nephronectin (LOC100101608)
  • nephronectin (Npnt)
  • 1110009H02Rik protein
  • AA682063 protein
  • AI314031 protein
  • EGFL6L protein
  • Nctn protein
  • POEM protein
  • si:ch211-202n8.2 protein

Protein level used designations for Nephronectin Proteins (NPNT)

nephronectin , nephronectin variant 1 , nephronectin variant 2 , nephronectin-like , preosteoblast EGF-like repeat protein with MAM domain

GENE ID SPECIES
461420 Pan troglodytes
563273 Danio rerio
694470 Macaca mulatta
100101608 Oryctolagus cuniculus
100137096 Xenopus (Silurana) tropicalis
100405330 Callithrix jacchus
100469947 Ailuropoda melanoleuca
100544176 Meleagris gallopavo
100601218 Nomascus leucogenys
114249 Mus musculus
422535 Gallus gallus
255743 Homo sapiens
487891 Canis lupus familiaris
513362 Bos taurus
100172375 Pongo abelii
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