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Functional ligand of integrin alpha-8/beta-1 in kidney development. Additionally we are shipping Nephronectin Antibodies (38) and Nephronectin Kits (10) and many more products for this protein.
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Morpholino-mediated knockdown of Npnt prevents proper heart valve leaflet formation and trabeculation and results in greater than 85% lethality at 7 days post-fertilization.
we found that bone morphogenic protein-2 (BMP-2 (show BMP2 Proteins)), known as an osteogenesis inducing cytokine, strongly up-regulated the expression of Npnt mRNA in a murine skeletal muscle cell line (C2C12) via the BMP-SMAD (show SMAD1 Proteins) signaling pathway
Nephronectin is capable of binding to heparan sulfate proteoglycans in basement membranes via the MAM domain.
These results indicate that Npnt plays an important role in the initiation of hepatitis by recruiting CD4 (show CD4 Proteins)(+) T cells or NKT (show CTSL1 Proteins) cells into the foci of inflammation.
canonical TGF-b signaling through Smad2 (show SMAD2 Proteins) regulates Npnt geneexpression in osteoblasts.
expression of a fragment containing the 3'-untranslated region (3'-UTR) of nephronectin in osteoblast progenitor cells MC3T3-E1 promoted cell differentiation
These results suggest that TNF-alpha (show TNF Proteins) inhibits POEM expression through the NF-kappaB (show NFKB1 Proteins) signaling pathway and down-regulation of POEM influences the inhibition of osteoblast differentiation by TNF-alpha (show TNF Proteins).
TGF-beta (show TGFB1 Proteins) inhibited differentiation of osteoblasts transfected with various truncated Npnt constructs, suggesting that TGF-beta (show TGFB1 Proteins) can exert a down-stream effect on Npnt function.
MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7
it was demonstrated that nephronectin promotes differentiation during osteoblast differentiation and the EGF (show EGF Proteins)-like repeats were essential.
results thus place nephronectin and alpha8beta1 integrin in a pathway that regulates Gdnf (show GDNF Proteins) expression and is essential for kidney development
The expression of nephronectin was sufficient to discriminate DN from other kidney diseases with mesangial matrix expansion and nodular lesions.
Nephronectin is associated with the development of diabetic glomerulosclerosis.
Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha- 8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity).
, nephronectin variant 1
, nephronectin variant 2
, preosteoblast EGF-like repeat protein with MAM domain