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The protein encoded by NEDD9 is a member of the CRK-associated substrates family. Additionally we are shipping NEDD9 Antibodies (68) and NEDD9 Kits (7) and many more products for this protein.
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HIP2 (show UBE2K Proteins) regulates mitotic spindle alignment. SHIP2 (show INPPL1 Proteins) is expressed in G1 phase, whereas Aurora A kinase (show AURKA Proteins) is enriched in mitosis. SHIP2 (show INPPL1 Proteins) binds Aurora A kinase (show AURKA Proteins) and the scaffolding protein HEF1 and promotes their basolateral localization at the expense of their luminal expression connected with cilia resorption.
The protein expression level of NEDD9 is higher in esophageal carcinoma tissues than that in adjacent normal tissues. Knockdown of NEDD9 expression can restrain the proliferation, invasion and migration of EC109 cells.
NEDD9 was able to partially overcome the inhibitory effects of miR (show MLXIP Proteins)-203 on colorectal cancer cell colony formation and invasion.
Increased NEDD9 expression is associated with metastatic endometrial and lung cancers.
NEDD9 has an essential role in development as well as in neoplastic cell proliferation, apoptosis, adhesion, migration and invasion. (Review)
The presence of the dna fragment in the NSCLC-N6-L16 (show MRPL16 Proteins) cell ChIP assays demonstrated a physical link between NEDD9 and p53 (show TP53 Proteins).
siRNA suppression of NEDD9 inhibits proliferation and enhances apoptosis in renal cell carcinoma (show MOK Proteins).
Serum NEDD9 was elevated in gastric cancer patients and had an unfavorable prognostic effect.
BCAR3 (show BCAR3 Proteins) is an essential interactor and mediator of HEF1-induced migration.
Study uncovers a new role of NEDD9 as a regulator of integrin trafficking through CAV1 (show CAV1 Proteins)-dependent endocytosis, and provide new insight into the regulation of migration of breast cancer cells.
a new role for Cas-L in T-cell activation, is reported.
These results suggest that Nedd9 is a Smad2 (show SMAD2 Proteins)/3 target gene implicated in RANKL (show TNFSF11 Proteins)-induced osteoclastogenesis.
NEDD9 is required for the maintenance of dendritic spines in the hippocampus.
Thus the RARE upstream of the Nedd9 2B promoter is necessary for much of the endogenous gene expression during early development as well as ectopic expression in response to atRA.
suggest that Cas-L/NEDD9 plays a pivotal role in the pathophysiology of CIA (show NCOA5 Proteins), and that Cas-L/NEDD9 may be a potential molecular target for the treatment of RA
Data indicate that Src kinase (show CSK Proteins) modulates the transit time of NEDD9 (neural precursor cell expressed developmentally down-regulated gene 9) at focal adhesion sites.
These results indicated an important modifier action of Nedd9 on autosomal dominant polycystic kidney disease pathogenesis involving failure to activate Aurora-A (show AURKA Proteins).
these results indicate a functional requirement for NEDD9 in the growth of mammary cancer progenitor cells
Tyrosine Y189 in the substrate domain of the adhesion docking protein NEDD9 is conserved with p130Cas (show BCAR1 Proteins) Y253 and regulates NEDD9-mediated migration and focal adhesion dynamics.
The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants.
neural precursor cell expressed, developmentally down-regulated 9
, enhancer of filamentation 1 homolog
, Cas scaffolding protein family member 2
, Crk-associated substrate related protein Cas-L
, Enhancer of filamentation 1 p55
, cas-like docking
, enhancer of filamentation 1
, neural precursor cell expressed developmentally down-regulated protein 9
, p130Cas-related protein
, renal carcinoma antigen NY-REN-12
, neural precursor cell expressed, developmentally down-regulated gene 9
, CRK-associated substrate-related protein
, Crk-associated substrate lymphocyte-specific protein