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NRN1 is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. Additionally we are shipping Neuritin 1 Antibodies (53) and Neuritin 1 Kits (16) and many more products for this protein.
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Human NRN1 Protein expressed in Baculovirus infected Insect Cells - ABIN2005310
Karamoysoyli, Burnand, Tomlinson, Gardiner: Neuritin mediates nerve growth factor-induced axonal regeneration and is deficient in experimental diabetic neuropathy. in Diabetes 2007
Show all 2 references for ABIN2005310
On analysis of the expression of NRN1 in SMA (show SMN1 Proteins) patients for the first time, NRN1 could be a potential modifier gene
Ca(2 (show CA2 Proteins)+)/calcineurin (show PPP3CA Proteins) (CaN)/nuclear factor of activated T-cells (NFAT (show NFATC1 Proteins)) c4 axis is required for neuritin-induced Kv4.2 (show KCND2 Proteins) transcriptional expression and potentiation of IA densities in cerebellum granule neurons.
(i) NRN1 variability is a shared risk factor for both schizophrenia-spectrum disorders (SSD) and bipolar disorders (BPD), (ii) NRN1 may have a selective impact on age at onset and intelligence in SSD.
Data indicate that neuritin not only plays an important role in the nervous system but also has an effect on the migration, senescence, proliferation, and viability of stem cells
Neuritin is reduced in the brains of Alzheimer's disease (AD) patients.
MiR (show MLXIP Proteins)-204 promotes apoptosis in oxidative stress-induced (show SQSTM1 Proteins) rat Schwann cells by suppressing neuritin expression
we found neuritin is overexpressed in astrocytoma, which may be an important factor in tumorigenesis and progression of astrocytoma
Data show that SMN (show STMN1 Proteins) and HuD (show ELAVL4 Proteins) form a complex in spinal motor axons, and that both interact with cpg15 mRNA in neurons.
NRN1 polymorphisms have roles in fluid intelligence in schizophrenia
By Northern blot, we confirm hypoxia-induced expression of insulin-like growth factor binding protein 3 (igfbp3 (show IGFBP3 Proteins)), thioredoxin-interacting protein (txnip (show TXNIP Proteins)), neuritin (nrn1).
Neuritin prevents extremely low-frequency electromagnetic fields-exposure-induced memory deficit by increasing the hippocampal spine density.
Neuritin can normalize neural deficits of Alzheimer's disease.
Neuritin restors the reduction in dendritic spine density and the maturity of individual spines in primary hippocampal neuron cultures from a Alzheimer disease mouse model.
Activity-dependent development of the visual system requires synapse stabilization and maturation via CPG15.
CPG15 acts to stabilize active synapses on dendritic spines, resulting in selective spine and arbor stabilization and synaptic maturation, and that synapse stabilization mediated by CPG15 is critical for efficient learning
Cpg15 is an immediate-early (show JUN Proteins) gene induced by Ca(2 (show CA2 Proteins)+) influx through NMDA receptors and L-type voltage-sensitive calcium channels. It requires convergent activation of the CaM kinase and MAP kinase (show MAPK1 Proteins) pathways.
Regulation of cpg15 expression during single whisker experience in the barrel cortex of adult mice.
Data show that neuritin expression is well correlated to the maturation of hepatocytes and can be a useful tool to define the differentiation stage of hepatocytes.
This gene is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. In vitro assays demonstrated that this protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis.
, neuritin 1
, candidate plasticity gene 15 protein
, candidate plasticity-related gene 15