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Neurofascin Proteins (NFASC)

NFASC encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. Additionally we are shipping Neurofascin Antibodies (49) and Neurofascin Kits (11) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NFASC 23114 O94856
NFASC 269116 Q810U3
Rat NFASC NFASC 116690 P97685
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Top Neurofascin Proteins at antibodies-online.com

Showing 10 out of 13 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
$341.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$806.30
Details
HOST_Human Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$983.48
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NFASC Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, ,
Mouse (Murine) ,
,

More Proteins for Neurofascin (NFASC) Interaction Partners

Human Neurofascin (NFASC) interaction partners

  1. -NF155 IgG4 antibodies were associated with a subgroup of patients with CIDP showing a younger age at onset, ataxia (show USP14 Proteins), tremor, CNS demyelination, and a poor response to IV immunoglobulin.

  2. Anti-neurofascin antibody is frequently present in patients with CCPD.

  3. Three neuronal proteins (Huntingtin interacting protein 1 (show HIP1 Proteins), neurofascin, and olfactomedin-like 2a) are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent (show SFRP5 Proteins) formation.

  4. gliomedin (show GLDN Proteins), NF186, and contactin are novel target antigens in Guillain-Barre syndrome

  5. Neurofascin isoforms of 186, 180, 166 and 155 kDa are generated by alternative splicing and provide a switch between neuronal plasticity and stability. (Review)

  6. Cerebellar pinceau organization requires coordinated mechanisms involving specific neurofascin functions in both Purkinje and basket neurons.

  7. Fibronectin (show FN1 Proteins) type III-like domains of neurofascin-186 protein mediate gliomedin (show GLDN Proteins) binding and its clustering at the developing nodes of Ranvier

  8. two crystal structures of a dimeric form of the headpiece of neurofascin

  9. Nfasc isoforms use distinct protein-protein interaction modules to organize and stabilize specific axonal domains in myelinated axons. Loss of Nfasc immunoglobulin domains 5 and 6 in transgenic mice mimics complete ablation of Nfasc.

  10. in both mouse and human samples, the expression pattern of neurofascin 155(high) and neurofascin 155(low) is altered coincident with paranodal decay.

Mouse (Murine) Neurofascin (NFASC) interaction partners

  1. we identify QKI (show QKI Proteins) as the long-sought regulator of Neurofascin alternative splicing

  2. P0/NFasc Interaction critical for the integrity of paranodal/nodal structures, but not for the stability of myelin

  3. Neurofascin 140 is essential for assembly of the node of Ranvier in embryogenesis.

  4. In embryonic mouse axons, AnkG is expressed at the beginning of axonogenesis at E9.5 and initially distributed homogeneously along the entire growing axon. From E11.5 the protein progressively becomes restricted to the proximal axon.

  5. the apparent dependency on sulfatide for maintaining Nfasc155 and MAG (show MAG Proteins) associations is intriguing since the fatty acid composition of sulfatide is altered and paranodal ultrastructure is compromised in multiple sclerosis

  6. Neurofascin is O-mannosylated and the glycosylation sites have been mapped.

  7. We propose that neurofascin optimizes communication between mature neurons by anchoring the key elements of the adult axon initial segment complex.

  8. Results suggest that neurofascin-dependent assembly of the nodal complex acts as a molecular boundary, facilitating axonal domain organization and saltatory conduction along myelinated axons.

  9. Nfasc isoforms use distinct protein-protein interaction modules to organize and stabilize specific axonal domains in myelinated axons: loss of Nfasc immunoglobulin domains 5 and 6 in mice mimics complete ablation of Nfasc.

  10. In both mouse and human samples, the expression pattern of neurofascin 155(high) and neurofascin 155(low) is altered coincident with paranodal decay.

Neurofascin (NFASC) Protein Profile

Protein Summary

This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. Both the AIS and nodes of Ranvier contain high densities of voltage-gated Na+ (Nav) channels which are clustered by interactions with cytoskeletal and scaffolding proteins including this protein, gliomedin, ankyrin 3 (ankyrin-G), and betaIV spectrin. This protein links the AIS extracellular matrix to the intracellular cytoskeleton. This gene undergoes extensive alternative splicing, and the full-length nature of some variants has not been determined.

Gene names and symbols associated with Neurofascin Proteins (NFASC)

  • neurofascin (NFASC)
  • neurofascin homolog (chicken) a (nfasca)
  • neurofascin (Nfasc)
  • neurofascin homolog (chicken) (NFASC)
  • neurofascin (LOC100351027)
  • AA387016 protein
  • D430023G06Rik protein
  • mKIAA0756 protein
  • NF protein
  • NRCAML protein
  • sc:d0205 protein

Protein level used designations for Neurofascin Proteins (NFASC)

neurofascin , neurofascin homolog , neurofascin homolog (chicken) , neurofascin-like , neurofascin homolog (chicken) isoform 1 , neurofascin homolog (chicken) isoform 2 , neurofascin homolog (chicken) isoform 3

GENE ID SPECIES
100075960 Ornithorhynchus anatinus
100141490 Danio rerio
100329041 Saccoglossus kowalevskii
699444 Macaca mulatta
100402675 Callithrix jacchus
23114 Homo sapiens
269116 Mus musculus
116690 Rattus norvegicus
419824 Gallus gallus
488565 Canis lupus familiaris
512796 Bos taurus
457660 Pan troglodytes
100054575 Equus caballus
100351027 Oryctolagus cuniculus
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