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Neurofilament, Light Polypeptide Proteins (NEFL)

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Additionally we are shipping Neurofilament, Light Polypeptide Antibodies (118) and Neurofilament, Light Polypeptide Kits (27) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NEFL 18039 P08551
NEFL 4747 P07196
NEFL 83613 P19527
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Top Neurofilament, Light Polypeptide Proteins at antibodies-online.com

Showing 10 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Mouse His tag 50 μg Log in to see 31 to 36 Days
$341.00
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
HOST_Escherichia coli (E. coli) Mouse His tag 100 μg Log in to see 11 to 13 Days
$616.00
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,545.67
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 11 to 13 Days
$668.80
Details
HOST_Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 9 to 19 Days
$794.65
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 19 Days
$841.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NEFL Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine) ,

Human , ,
,
Rat (Rattus)

More Proteins for Neurofilament, Light Polypeptide (NEFL) Interaction Partners

Mouse (Murine) Neurofilament, Light Polypeptide (NEFL) interaction partners

  1. Nefl(N98S/+) mice had a noticeable tremor, and most animals showed a hindlimb clasping similar to human Charcot-Marie-Tooth Type 2E phenotype.

  2. The finding of this study suggested that a lack of NFL protein alters the expression of cytoskeletal proteins and disrupts other NF subunits, causing intracellular aggregation but not gross structural changes in cortical neurons or cytoarchitecture.

  3. Neurofilament light chain (NFL) and neuronal intermediate filament protein (show GFAP Proteins) alpha-internexin (show INA Proteins) accumulate in axon swellings in the spinal white matter in a superoxide dismutase (SOD)-1 (show SOD1 Proteins) mouse model.

  4. Data suggest that tetrahydropapaveroline (an endogenous catechol) causes oxidative stress resulting in astrocyte/neuronal cell death via generation of reactive oxygen species and modification/aggregation of NF-L (as in neurodegenerative diseases).

  5. Data show that mitochondria essentially stopped moving in neurons expressing neurofilament protein (NFL) mutants, probably a consequence of cytoskeletal disruption.

  6. Myo Va interactions with intermediate filament proteins may serve similar roles in organizing organelle topography in different cell types.

  7. NEFL transgenic mice exhibited extended duration of the hindlimb clasping response and gait anomalies, as well as sensorimotor deficits in stationary beam and suspended bar tests

  8. Neuropathic effects of overexpressing NF-L can occur at the level of transgene RNA and are mediated by sequences in the NF-L 3' UTR

  9. nNOS (show NOS1 Proteins) inhibitor, AR-R17477AR, prevents the loss of NF68 immunoreactivity induced by methamphetamine in the mouse striatum

  10. The 3' untranslated region of light neurofilament (NF-L) transcript enhances the reactivity of its own translated product and leads to loss of solubility and aggregation of NF-L protein and to coaggregation of mutant superoxide dismutase 1 (SOD1 (show SOD1 Proteins)) protein

Human Neurofilament, Light Polypeptide (NEFL) interaction partners

  1. The results showed an important role for miR (show MLXIP Proteins)-25 in regulating NEFL expression in Glioblastoma multiforme.

  2. Finally, we demonstrated that NEFL inhibited the NF-kappaB (show NFKB1 Proteins) pathway, thereby suppressing the expression of uPA (show PRAP1 Proteins) and decreasing NSCLC invasiveness and migration.

  3. Cerebrospinal fluid NFL concentration is increased by the early clinical stage of Alzheimer's Disease.

  4. The miR (show MLXIP Proteins)-381-NEFL axis is important for temozolomide resistance in glioblastoma multiforme.

  5. The results od this study concluded that NEFL E396K mutation may manifest with a novel DI-CMT phenotype, characterized by simultaneous involvement of the peripheral and central nervous system.

  6. Suggest monitoring the serum level of antibodies against the NF-L chain as a predictive biomarker of treatment response in multiple sclerosis.

  7. a novel heterozygous missense mutation c.1166A>G (p.Y389C) in the gene encoding the light-chain neurofilament protein was identified in 4 patients resulting in hereditary motor and sensory neuropathy with pyramidal signs phenotype.

  8. Data suggest that, while lacking a stable structure, NFL-TBS.40-63 peptide (a peptide derived from light neurofilament protein) preferentially binds on a specific single site located near C-terminal end of beta-tubulin (show TUBB Proteins).

  9. Blood-derived NfL level is an easily accessible biomarker with prognostic value in ALS.

  10. Data indicate that the N terminus of Pro-EMAP II binds to its C terminus, arginyl-tRNA synthetase (show RARS Proteins), and the neurofilament light subunit.

Neurofilament, Light Polypeptide (NEFL) Protein Profile

Protein Summary

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and they functionally maintain the neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the light chain neurofilament protein. Mutations in this gene cause Charcot-Marie-Tooth disease types 1F (CMT1F) and 2E (CMT2E), disorders of the peripheral nervous system that are characterized by distinct neuropathies. A pseudogene has been identified on chromosome Y.

Gene names and symbols associated with NEFL

  • neurofilament, light polypeptide (NEFL)
  • neurofilament, light polypeptide b (neflb)
  • neurofilament, light polypeptide (Nefl)
  • neurofilament, light polypeptide (nefl)
  • AI847934 protein
  • CMT1F protein
  • CMT2E protein
  • nefl protein
  • NF-L protein
  • NF68 protein
  • NFL protein
  • XNF-L protein
  • zgc:136626 protein

Protein level used designations for NEFL

neurofilament, light polypeptide 68kDa , neurofilament, light polypeptide , neurofilament light polypeptide , 68 kDa neurofilament protein , neurofilament protein L , neurofilament triplet L protein , light molecular weight neurofilament protein , neurofilament protein, light chain , neurofilament subunit NF-L , NF-L , micro glutamic acid-rich protein , neurofilament protein , Neurofilament triplet L protein

GENE ID SPECIES
464063 Pan troglodytes
477378 Canis lupus familiaris
641444 Macaca mulatta
664698 Danio rerio
18039 Mus musculus
4747 Homo sapiens
83613 Rattus norvegicus
281348 Bos taurus
100521224 Sus scrofa
397822 Xenopus laevis
419528 Gallus gallus
100173482 Pongo abelii
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