Neutrophil Cytosolic Factor 2 Proteins (NCF2)

NCF2 encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. Additionally we are shipping NCF2 Antibodies (50) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NCF2 4688 P19878
NCF2 17970 O70145
NCF2 364018 A7E3N2
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Top NCF2 Proteins at antibodies-online.com

Showing 9 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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Baculovirus infected Insect Cells Human Un-conjugated 100 μg Log in to see 20 to 21 Days
$382.80
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Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$640.00
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Escherichia coli (E. coli) Mouse His tag,T7 tag 100 μg Log in to see 15 to 18 Days
$656.00
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
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Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$3,501.67
Details
Escherichia coli (E. coli) Mouse Un-conjugated   100 μg Log in to see 11 to 18 Days
$852.50
Details

NCF2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , , ,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Neutrophil Cytosolic Factor 2 (NCF2) Interaction Partners

Pig (Porcine) Neutrophil Cytosolic Factor 2 (NCF2) interaction partners

  1. analysis of NCF2, BCKDHB (show BCKDHB Proteins) and BCKDHA (show BCKDHA Proteins) in pig

Human Neutrophil Cytosolic Factor 2 (NCF2) interaction partners

  1. We analyzed the clinical and laboratory findings of CGD (show CYBB Proteins) with mutations in the NCF2 gene from amongst our cohort of CGD (show CYBB Proteins) patients. A homozygous mutation (c.835_836delAC, p.T279fsX294), a deletion in NCF2 gene was found in two cases. In the third case, two heterozygous mutations were detected, IVS13-2A>T on one allele and c.1099C>T (p.) on the other allele.

  2. All investigated patients presented the same mutation (c.257 + 2T > C) in NCF2 gene. We show that this mutation is responsible for a drastic decrease of p67phox mRNA and leads to the skipping of exon 3 detected in the low amount of residual mRNA.

  3. Phosphoinositol 3-phosphate regulates reactive oxygen species production by maintaining p40phox (show NCF4 Proteins) and p67phox at the phagosomal membrane.

  4. TLR4 (show TLR4 Proteins)- and TLR2-induced IRAK (show IRAK1 Proteins)-ERK (show EPHB2 Proteins) pathway cross-talks with p67phox-Nox-2 (show CYBB Proteins) for reactive oxygen species generation, thus regulating IL-1beta (show IL1B Proteins) transcription and processing in monocytic cells.

  5. Skeletal muscle protein expression of the NADPH oxidase (show NOX1 Proteins) subunits p22(phox (show CYBA Proteins)), p47(phox), and p67(phox) was increased in obese relative to lean subjects, where p22(phox (show CYBA Proteins)) and p67(phox) expression was attenuated by exercise training in obese subjects.

  6. A novel homozygous mutation in NCF2.

  7. results reveal an essential role for the Cys (show DNAJC5 Proteins)-Gly-Cys (show DNAJC5 Proteins) triad in Nox2 (show CYBB Proteins) in binding p67(phox), seconded by an additional binding region, comprising residues C terminal to Cys (show DNAJC5 Proteins)-Gly-Cys (show DNAJC5 Proteins). The 2 regions interact with distinct partner sites in p67(phox).

  8. This model assigns a central role to Arg-395 in the structure and stability of the quaternary NCF2/NCF4 (show NCF4 Proteins)/VAV1 (show VAV1 Proteins)/RAC1 NADPH oxidase (show NOX1 Proteins) complex.

  9. Data indicate that arachidonic acid induces the direct interaction of Rac (show AKT1 Proteins)-GTP (show AK3 Proteins)-bound p67(phox) with the C-terminal cytosolic region of phagocyte NADPH oxidase (show NOX1 Proteins) Nox2 (show CYBB Proteins).

  10. Four novel mutations in the NCF1 (show NCF1 Proteins), NCF2, and CYBB (show CYBB Proteins) genees have been identified in chronic granulomatous disease patients in Morocco.

Mouse (Murine) Neutrophil Cytosolic Factor 2 (NCF2) interaction partners

  1. Just as patients with chronic granulomatous disease who lack NADPH oxidase (show NOX1 Proteins) rarely develop SLE, NCF-2-null mice on a nonautoimmune background were susceptible to a chronic granulomatous disease-like opportunistic infection but did not develop lupus. In contrast, on a lupus-prone background, even haploinsufficiency of NCF-2 accelerated the development of full-blown lupus disease.

  2. p67(phox) binds to phosphoPrdx6 and inhibits its PLA2 (show PLA2G2A Proteins) activity, an interaction that could function to terminate the PLA2 (show PLA2G2A Proteins)-mediated NOX2 (show CYBB Proteins) activation signal.

  3. The results of this study suggested that repeated stress promotes depressive behavior through the upregulation of NADPH (show FDXR Proteins) oxidasesubunit (67kDa (show RPSA Proteins)) and the resultant metabolic oxidative stress.

  4. Data suggest that a cytosolic source of reactive oxygen species, probably p67(phox) subunit of cardiac NADPH oxidase 2 (NOX2 (show CYBB Proteins)), may contribute to the hypertrophic phenotype in glucose transporter 4 gene (GLUT4 (show SLC2A4 Proteins)-/-) mice.

  5. This report evaluates neutrophil cytosolic factor 2 (Ncf2) as a candidate Salmonella susceptibility gene for Ity3.

  6. This study demonstrates the involvement of ROS (show ROS1 Proteins) from NADPH oxidase (show NOX1 Proteins) in mediating paraquat cytotoxicity in BV-2 microglial cells and this process is mediated through PKCdelta (show PKCd Proteins)- and ERK (show EPHB2 Proteins)-dependent pathways.

NCF2 Protein Profile

Protein Summary

This gene encodes neutrophil cytosolic factor 2, the 67-kilodalton cytosolic subunit of the multi-protein NADPH oxidase complex found in neutrophils. This oxidase produces a burst of superoxide which is delivered to the lumen of the neutrophil phagosome. Mutations in this gene, as well as in other NADPH oxidase subunits, can result in chronic granulomatous disease, a disease that causes recurrent infections by catalase-positive organisms. Alternative splicing results in multiple transcript variants encoding different isoforms.

Gene names and symbols associated with NCF2

  • neutrophil cytosolic factor 2 (NCF2)
  • neutrophil cytosolic factor 2 L homeolog (ncf2.L)
  • neutrophil cytosolic factor 2 (ncf2)
  • neutrophil cytosolic factor 2 (p67phox)
  • neutrophil cytosol factor 2 (VDBG_06643)
  • hypothetical protein (PGTG_05816)
  • neutrophil cytosolic factor 2 (LOC100136240)
  • neutrophil cytosolic factor 2 (Ncf2)
  • MGC81877 protein
  • Ncf-2 protein
  • NOXA2 protein
  • P67-PHOX protein
  • P67PHOX protein
  • zgc:158405 protein

Protein level used designations for NCF2

neutrophil cytosolic factor 2 (65kDa, chronic granulomatous disease, autosomal 2) , neutrophil cytosolic factor 2 , neutrophil cytosol factor 2 , predicted neutrophil cytosolic factor 2 , p67phox , p67-phox , NADPH oxidase cytosolic protein p67phox , NADPH oxidase cytosolic protein , 67 kDa neutrophil oxidase factor , NADPH oxidase activator 2 , chronic granulomatous disease, autosomal 2 , neutrophil NADPH oxidase factor 2 , neutrophil cytosolic factor 2 (65kD, chronic granulomatous disease, autosomal 2) , NADPH oxidase subunit (67 kD) , NADPH oxidase subunit (67kDa) , NCF-2

GENE ID SPECIES
424445 Gallus gallus
444487 Xenopus laevis
457573 Pan troglodytes
480036 Canis lupus familiaris
562473 Danio rerio
619224 Ciona intestinalis
619367 Xenopus (Silurana) tropicalis
9537124 Verticillium alfalfae VaMs.102
10531323 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100008802 Oryctolagus cuniculus
100136240 Oncorhynchus mykiss
100142665 Sus scrofa
100174692 Pongo abelii
100270811 Salmo salar
4688 Homo sapiens
17970 Mus musculus
364018 Rattus norvegicus
281346 Bos taurus
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