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Neutrophil Cytosolic Factor 4, 40kDa Proteins (NCF4)

The protein encoded by NCF4 is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. Additionally we are shipping Neutrophil Cytosolic Factor 4, 40kDa Antibodies (108) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NCF4 17972 P97369
Rat NCF4 NCF4 500904  
NCF4 4689 Q15080
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Top Neutrophil Cytosolic Factor 4, 40kDa Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$407.00
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 3 to 4 Days
$498.21
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 9 to 11 Days
$229.85
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

NCF4 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
,

Top referenced Neutrophil Cytosolic Factor 4, 40kDa Proteins

  1. Human NCF4 Protein expressed in Escherichia coli (E. coli) - ABIN1098430 : Eglinton, Roberts, Pearson, Barclay, Merriman, Frizelle, Gearry: Clinical and genetic risk factors for perianal Crohn's disease in a population-based cohort. in The American journal of gastroenterology 2012 (PubMed)

More Proteins for Neutrophil Cytosolic Factor 4, 40kDa (NCF4) Interaction Partners

Mouse (Murine) Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. p40phox deficiency leads to upregulation of chemokine receptor 1 (show CMKLR1 Proteins) and downregulation of fucosyltransferases and sialyltransferases involved in glycan modifications during experimental intestinal inflammation.

  2. cooperation of p40(phox) with p47(phox) for Nox2 (show CYBB Proteins)-based NADPH oxidase (show NOX1 Proteins) activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis

  3. The defect in Reactive Oxygen Species production and killing of s aureus by p40(phox-/-) neutrophils defines p40(phox) as an essential component in bacterial killing.

  4. p40 (show LANCL1 Proteins)(phoxR58A/R58A) embryos do not develop normally but p40 (show LANCL1 Proteins)(phoxR58A/-) mice are viable and neutrophils from these animals exhibit significantly reduced oxidase responses compared to those from their p40(phox+/-) siblings.

  5. Class III PI3K Vps34 (show PIK3C3 Proteins) is responsible for the synthesis of PtdIns(3)P on phagosomes containing either S aureus or E coli. PtdIns(3)P binding to p40(phox) is important for CD18 (show ITGB2 Proteins)-dependent activation oxidase activation in response to S aureus and E coli

  6. p40(phox) is prephosphorylated in resting endothelial cells and can compensate p47(phox) in keeping basal ROS (show ROS1 Proteins) production.

Human Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. NCF4 polymorphism was associated with Crohn's disease, but not ulcerative colitis in Caucasian--{REVIEW}

  2. NCF4 may induce ex- pression of NADPH oxidase (show NOX1 Proteins) enzymes, such as p67phox (show NCF2 Proteins), p47phox, p22phox (show CYBA Proteins) and NOX2 (show CYBB Proteins), which lead to increased ROS (show ROS1 Proteins) levels.

  3. Germline variation in NCF4, an innate immunity gene, is associated with an increased risk of colorectal cancer.

  4. The contribution of the functionally relevant NADPH (show NQO1 Proteins) polymorphisms rs1883112 and rs4673 to anthracycline-related heart lesions provides a plausible explanation for their modulation of cardiotoxicity.

  5. Constitutive and inducible intracellular production of reactive oxygen species (ROS (show ROS1 Proteins)) is higher in B cells expressing functional p40phox, supporting a direct role for p40phox in regulating B cell intracellular ROS (show ROS1 Proteins) generation.

  6. Genome-wide association studies-reported associations between the NELL1, NCF4, and FAM92B genes and susceptibility to Crohn's disease could not be replicated in Canadian children and young adults.

  7. Younger age at diagnosis, complicated disease behavior, and ileal disease location are risk factors for perianal CD. First report of an association of the NCF4 gene with perianal disease.

  8. cooperation of p40(phox) with p47(phox) for Nox2 (show CYBB Proteins)-based NADPH oxidase (show NOX1 Proteins) activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis

  9. Results demonstrate that PBEF (show NAMPT Proteins) can prime for PMN (show TBCE Proteins) respiratory burst activity by promoting p40 (show IL9 Proteins) and p47 (show ING1 Proteins) translocation to the membrane.

  10. cytosolic localisation depends on direct interaction with F-actin

Cow (Bovine) Neutrophil Cytosolic Factor 4, 40kDa (NCF4) interaction partners

  1. Study proposes that NCF4 splice variants generated by functional SNP are important risk factors for mastitis susceptibility in dairy cows.

Neutrophil Cytosolic Factor 4, 40kDa (NCF4) Protein Profile

Protein Summary

The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Gene names and symbols associated with NCF4

  • p40phox protein (p40phox)
  • neutrophil cytosolic factor 4 (LOC100136241)
  • neutrophil cytosolic factor 4 (Ncf4)
  • neutrophil cytosolic factor 4, 40kDa (NCF4)
  • AI451400 protein
  • NCF protein
  • P40PHOX protein
  • SH3PXD4 protein

Protein level used designations for NCF4

p40phox protein , neutrophil cytosolic factor 4 , NADPH oxidase cytosolic protein p40phox , NCF-4 , neutrophil NADPH oxidase factor 4 , neutrophil cytosol factor 4 , p40-phox , SH3 and PX domain-containing protein 4

GENE ID SPECIES
445891 Takifugu rubripes
100136241 Oncorhynchus mykiss
17972 Mus musculus
500904 Rattus norvegicus
4689 Homo sapiens
481277 Canis lupus familiaris
507859 Bos taurus
100009359 Oryctolagus cuniculus
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