NCF4 Products
(Neutrophil Cytosolic Factor 4, 40kDa (NCF4))
Categories
The protein encoded by this gene is a cytosolic regulatory component of the superoxide-producing phagocyte NADPH-oxidase, a multicomponent enzyme system important for host defense. This protein is preferentially expressed in cells of myeloid lineage. It interacts primarily with neutrophil cytosolic factor 2 (NCF2/p67-phox) to form a complex with neutrophil cytosolic factor 1 (NCF1/p47-phox), which further interacts with the small G protein RAC1 and translocates to the membrane upon cell stimulation. This complex then activates flavocytochrome b, the membrane-integrated catalytic core of the enzyme system. The PX domain of this protein can bind phospholipid products of the PI(3) kinase, which suggests its role in PI(3) kinase-mediated signaling events. The phosphorylation of this protein was found to negatively regulate the enzyme activity. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008].
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Featured NCF4 Categories
NCF4 Antibodies
High quality antibodies with extensive validation data.
NCF4 Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended NCF4 Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Mouse
Application
WB, IHC, IP, ICC
Validations
- (5)
Cat. No.
ABIN7442450
Quantity
100 μL
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, ELISA
Validations
- (4)
Cat. No.
ABIN190755
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IHC, IP
Validations
- (4)
Cat. No.
ABIN7268900
Quantity
100 μL
Datasheet
Datasheet
Recommended NCF4 Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124162
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312099
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1312101
Quantity
10 μg
Datasheet
Datasheet
Latest Publications for our NCF4 products
: "Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis. ..." in: Nature genetics, Vol. 39, Issue 5, pp. 596-604, (2007) (PubMed).Synonyms and alternative names related to NCF4
neutrophil cytosolic factor 4 (ncf4), neutrophil cytosolic factor 4 (Ncf4), neutrophil cytosolic factor 4 (NCF4), AI451400, NCF, p40phox, P40PHOX, SH3PXD4Protein level used designations for NCF4
- p40phox protein
- neutrophil cytosolic factor 4
- NADPH oxidase cytosolic protein p40phox
- NCF-4
- neutrophil NADPH oxidase factor 4
- neutrophil cytosol factor 4
- p40-phox
- SH3 and PX domain-containing protein 4
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