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Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. Additionally we are shipping Neutrophil Cytosolic Factor 4 Antibodies (4) and many more products for this protein.
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p40phox deficiency leads to upregulation of chemokine receptor 1 (show CMKLR1 Proteins) and downregulation of fucosyltransferases and sialyltransferases involved in glycan modifications during experimental intestinal inflammation.
cooperation of p40(phox) with p47(phox) for Nox2 (show CYBB Proteins)-based NADPH oxidase (show NOX1 Proteins) activation during Fcgamma receptor (FcgammaR)-mediated phagocytosis
The defect in Reactive Oxygen Species production and killing of s aureus by p40(phox-/-) neutrophils defines p40(phox) as an essential component in bacterial killing.
p40 (show LANCL1 Proteins)(phoxR58A/R58A) embryos do not develop normally but p40 (show LANCL1 Proteins)(phoxR58A/-) mice are viable and neutrophils from these animals exhibit significantly reduced oxidase responses compared to those from their p40(phox+/-) siblings.
Class III PI3K Vps34 (show PIK3C3 Proteins) is responsible for the synthesis of PtdIns(3)P on phagosomes containing either S aureus or E coli. PtdIns(3)P binding to p40(phox) is important for CD18 (show ITGB2 Proteins)-dependent activation oxidase activation in response to S aureus and E coli
p40(phox) is prephosphorylated in resting endothelial cells and can compensate p47(phox) in keeping basal ROS (show ROS1 Proteins) production.
Component of the NADPH-oxidase, a multicomponent enzyme system responsible for the oxidative burst in which electrons are transported from NADPH to molecular oxygen, generating reactive oxidant intermediates. It may be important for the assembly and/or activation of the NADPH-oxidase complex.
, neutrophil NADPH oxidase factor 4
, neutrophil cytosol factor 4