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N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. Additionally we are shipping NNMT Antibodies (111) and NNMT Kits (16) and many more products for this protein.
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These findings indicate that the repression of NNMT may underlie nickel-induced H3K9 dimethylation by altering the cellular SAM (show TTN Proteins)/SAH (show ACSM3 Proteins) ratio.
NNMT expression is significantly upregulated in human masticatory mucosa during wound healing
The results show that a SNP (rs1941404) in NNMT is significantly associated with hyperlipidemia, and the influence of rs1941404 variation on the resting energy expenditure may be the possible mechanism for rs1941404 variation to induce hyperlipidemia.
NNMT gene rs694539 variant is a genetic risk factor for migraine in women.
There were no associations between MTHFR (show MTHFR Proteins) C677T, NNMT rs694539 AG/AA polymorphisms and conotruncal heart disease.
Data show that nicotinamide N-methyltransferase (NNMT) and the metabolic state regulate pluripotency in embryonic stem cells (hESCs).
results further reinforce a central role for NNMT in the regulation of energy homeostasis and provide further mechanistic insight into the consequences of enhanced NNMT expression
White adipose tissue NNMT expression is regulated in human insulin (show INS Proteins) resistance and type 2 diabetes and that plasma MNA correlates with increased tissue NNMT expression and the degree of insulin (show INS Proteins) resistance.
The downregulation of NNMT significantly reduced in vitro tumorigenicity of A549 cells.
increasing Nnmt expression or MNAM levels stabilizes sirtuin 1 (show SIRT1 Proteins) protein, an effect that is required for their metabolic benefits
Crystal structures of monkey and mouse nicotinamide N-methyltransferase (NNMT) bound with end product, 1-methyl nicotinamide have been presented.
NNMT is a novel regulator of histone methylation, polyamine flux and NAD(+)-dependent SIRT1 (show SIRT1 Proteins) signalling, and is a unique and attractive target for treating obesity and type 2 diabetes
Brain NNMT expression was not altered in hyperhomocysteinemia.
Adipose tissue is a source of nicotinamide N-methyltransferase and homocysteine.
the progression of vascular inflammation and atherosclerosis was associated with the upregulation of hepatic nicotinamide N-methyltransferase activity and subsequent increase in endogenous MNA plasma levels
N-methylation is one method by which drug and other xenobiotic compounds are metabolized by the liver. This gene encodes the protein responsible for this enzymatic activity which uses S-adenosyl methionine as the methyl donor.
, nicotinamide n-methyltransferase
, Nicotinamide N-methyltransferase