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Nicotinamide Nucleotide Transhydrogenase Proteins (NNT)

NNT encodes an integral protein of the inner mitochondrial membrane. Additionally we are shipping NNT Antibodies (41) and NNT Kits (1) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NNT 23530 Q13423
NNT 18115  
Rat NNT NNT 310378  
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Top NNT Proteins at antibodies-online.com

Showing 5 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 69 to 74 Days
$12,906.52
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 69 to 74 Days
$9,050.32
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details

NNT Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
,

More Proteins for Nicotinamide Nucleotide Transhydrogenase (NNT) Interaction Partners

Caenorhabditis elegans (C. elegans) Nicotinamide Nucleotide Transhydrogenase (NNT) interaction partners

  1. nnt-1 is important in the defense against mitochondrial oxidative stress

Human Nicotinamide Nucleotide Transhydrogenase (NNT) interaction partners

  1. This report of a novel NNT mutation, p.G200S, expands the phenotype of NNT mutations to include mineralocorticoid deficiency. It provides the first evidence that NNT mutations can cause oxidative stress and mitochondrial defects.

  2. Data suggest mutations in nicotinamide nucleotide transhydrogenase (NNT) as contributory to left ventricular noncompaction (LVNC).

  3. NNT mRNA expression is significantly higher in visceral fat of obese patients and correlates with body weight, BMI, % body fat, visceral and sc fat area, waist and hip circumference, and fasting plasma insulin (show INS Proteins).

  4. Results suggest that NNT may have a role in ROS (show ROS1 Proteins) detoxification in human adrenal glands.

  5. In the failing heart a partial loss of Nnt activity adversely impacts NADPH (show NQO1 Proteins)-dependent enzymes and the capacity to maintain membrane potential, thus contributing to a decline in bioenergetic capacity, redox regulation and antioxidant defense.

Mouse (Murine) Nicotinamide Nucleotide Transhydrogenase (NNT) interaction partners

  1. Pathologic workload reverses Nnt to deplete NADPH (show FDXR Proteins) and antioxidative capacity. Reverse Nnt induces mitochondrial oxidative stress and necrosis.

  2. In mitochondria, genetic or pharmacological disruptions in the PDHC-NNT redox circuit negate counterbalance changes in energy expenditure

  3. Data conclude that Herpud1 (show HERPUD1 Proteins) regulates insulin (show INS Proteins) secretion via control of Nnt expression.

  4. our data suggest that NNT functions as a high-capacity source of mitochondrial NADPH (show FDXR Proteins) and that its functional loss due to the Nnt mutation results in mitochondrial redox abnormalities

  5. the role of NNT in regulating central carbon metabolism via redox balance, calling for other mechanisms that coordinate substrate preference to maintain a functional TCA cycle.

  6. Our results demonstrate a novel role for NNT as a regulator of macrophage-mediated inflammatory responses

  7. A normal Nnt allele can help with better cardiac function in MnSOD (show SOD2 Proteins)-deficient mice during fetal development.

  8. The presence of a truncated Nnt did not affect insulin (show INS Proteins) secretion or glucose tolerance on the C57BL/6 background.

  9. Nnt was identified as a novel candidate gene for contribution to glucose intolerance through reduced beta cell activity.

  10. Mutations/deletion uncouple pancreatic beta cell mitochondrial metabolism leading to less ATP production, enhanced KATP channel activity, and consequently impaired insulin (show INS Proteins) secretion.

NNT Protein Profile

Protein Summary

This gene encodes an integral protein of the inner mitochondrial membrane. The enzyme couples hydride transfer between NAD(H) and NADP(+) to proton translocation across the inner mitochondrial membrane. Under most physiological conditions, the enzyme uses energy from the mitochondrial proton gradient to produce high concentrations of NADPH. The resulting NADPH is used for biosynthesis and in free radical detoxification. Two alternatively spliced variants, encoding the same protein, have been found for this gene.

Gene names and symbols associated with NNT

  • Nicotinamide Nucleotide Transhydrogenase (nnt-1)
  • nicotinamide nucleotide transhydrogenase (AFUA_5G02780)
  • nicotinamide nucleotide transhydrogenase (nnt)
  • nicotinamide nucleotide transhydrogenase (NNT)
  • nicotinamide nucleotide transhydrogenase (Nnt)
  • 4930423F13Rik protein
  • Afu5g02780 protein
  • AI323702 protein
  • BB168308 protein
  • GCCD4 protein
  • wu:fa20d10 protein
  • wu:fc86a04 protein
  • zgc:76979 protein

Protein level used designations for NNT

Nicotinamide Nucleotide Transhydrogenase family member (nnt-1) , nicotinamide nucleotide transhydrogenase , NAD(P) transhydrogenase, mitochondrial , pyridine nucleotide transhydrogenase , Nicotinamide nucleotide transhydrogenase (NAD(P)+ transhydrogenase)

GENE ID SPECIES
180884 Caenorhabditis elegans
3505502 Aspergillus fumigatus Af293
100158572 Xenopus (Silurana) tropicalis
23530 Homo sapiens
18115 Mus musculus
310378 Rattus norvegicus
406619 Danio rerio
447528 Xenopus laevis
427196 Gallus gallus
280878 Bos taurus
479342 Canis lupus familiaris
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