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NID2 encodes a member of the nidogen family of basement membrane proteins. Additionally we are shipping Nidogen 2 Antibodies (57) and Nidogen 2 Kits (21) and many more products for this protein.
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Nidogen-2, a protein shown to be expressed intracellularly and for secretion by pre-adipocytes, was shown to interact, through its globular G3 domain, with TRAP 5a in vitro.
show that loss of nidogen 2, but not of nidogen 1 (show NID1 Proteins), promotes lung metastasis of melanoma cells. Histological and ultrastructural analysis of nidogen 1 (show NID1 Proteins)- and 2-deficient lungs did not reveal differences in morphology and ultrastructure of basement membrane
Basement membrane deposition of nidogen 1 but not nidogen 2 requires the nidogen binding module of the laminin gamma1 chain.
These findings revealed extensive coregulation of nidogen-1 (show NID1 Proteins) and -2 expression and much more complementary functions of the two nidogens than previously recognized.
Nid2 is essential for late stages of lung development and for maintenance and/or integrity of cardiac tissue
nidogen-2 is equivalent to nidogen-1 (show NID1 Proteins) in skin-organotypic coculture, and both can promote the development of a functional basement membrane zone
nidogen-1 (show NID1 Proteins) and -2 have roles in development of the ectodermal basement membrane of the limb bud
decreased expression of the entactin-2 gene after treatment of the cells with ent-2 (show SLC29A2 Proteins)-specific siRNA preparation led to reduced expression of the cell cycle inhibitor p21
The lack of nidogen-1 (show NID1 Proteins), nidogen-2, or both nidogens, plays no crucial role in the occurrence and localization of laminin-111, collagen type IV (show COL4 Proteins), and perlecan (show HSPG2 Proteins) in murine tubular renal basement membranes.
In capillaries, basement membrane formation is severely impaired in the absence of nidogen-1 (show NID1 Proteins) and -2, showing an irregular, patchy distribution and a dramatically reduced deposition of collagen IV (show COL4 Proteins), perlecan (show HSPG2 Proteins), and particularly laminin-411.
Knockdown of nidogen-2 reduced SOX9 (show SOX9 Proteins) expression, whereas it up-regulated RUNX2 (show RUNX2 Proteins) expression
The cleavage of nidogen-1 (show NID1 Proteins) and -2 is partially inhibited in human tumor samples.
combined methylation analysis of Twist homolog 1 (show TWIST1 Proteins) and nidogen-2 genes may be a simple, noninvasive, sensitive, and specific method for detecting cancer cells in urine.
Decreased nidogen-2 expression is associated with hepatocellular carcinoma
NID2 promoter hypermethylation is associated with oral cavity squamous cell carcinoma.
Nidogen-2 is a new biomarker for ovarian cancer which correlates closely with CA125 (show MUC16 Proteins).
short arm region of laminin-5 gamma2 chain: structure, mechanism of processing and binding to heparin, nidogen-1 (show NID1 Proteins), fibulin-1 (show FBLN1 Proteins) and fibulin-2 (show FBLN2 Proteins)
Nidogen-2 compensation hypothesis to explain limited phenotype observed following elimination of nidogen-1 (show NID1 Proteins) gene.
CpG islands of both NID1 (show NID1 Proteins) and NID2 genes are aberrantly methylated in human cancer samples and cancer cell lines.
This gene encodes a member of the nidogen family of basement membrane proteins. This protein is a cell-adhesion protein that binds collagens I and IV and laminin and may be involved in maintaining the structure of the basement membrane.