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anti-Niemann-Pick Disease, Type C1 (NPC1) Antibodies

NPC1 encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. Additionally we are shipping Niemann-Pick Disease, Type C1 Proteins (10) and Niemann-Pick Disease, Type C1 Kits (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
NPC1 18145 O35604
NPC1 4864 O15118
NPC1 266732  
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Top anti-Niemann-Pick Disease, Type C1 Antibodies at antibodies-online.com

Showing 10 out of 70 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Mouse Un-conjugated IHC, ELISA, WB 0.1 mg Log in to see 3 to 4 Days
$430.10
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged NPC1 is approximately 0.03 ... 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Human Rabbit Un-conjugated IF, IHC (p), WB NPC1 Antibody (Center)  western blot analysis in NCI-H460 cell line ly... Confocal immunofluorescent analysis of NPC1 Antibody (Center)  with 29... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of NPC1 in mouse kidney tissue with this product ... Western blot analysis of NPC1 in human kidney tissue lysate with this ... 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Mouse PE FACS 100 Tests Log in to see 10 to 12 Days
$282.64
Details
Human Rabbit Un-conjugated ELISA, IHC (p), WB Anti-NPC1 antibody IHC staining of human adrenal. Immunohistochemistry... Anti-NPC1 antibody IHC staining of human brain, cortex. Immunohistoche... 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Goat Un-conjugated ELISA, WB   0.1 mg Log in to see 2 to 3 Days
$433.13
Details
Human Mouse Un-conjugated IF, IHC (p), IP, WB Human Colon (formalin-fixed, paraffin-embedded) stained with NPC1 anti... Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with N... 50 μg Log in to see 8 to 10 Days
$595.83
Details
Human Rabbit Alkaline Phosphatase (AP) ICC, IHC, ELISA, WB   200 μL Log in to see 8 to 10 Days
$969.83
Details
Human Rabbit Un-conjugated WB   100 μL Log in to see 8 to 10 Days
$383.17
Details

NPC1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Mouse (Murine) , , , ,
,
Human , , , ,
, ,
Rat (Rattus) , , , ,

Top referenced anti-Niemann-Pick Disease, Type C1 Antibodies

  1. Human Monoclonal NPC1 Primary Antibody for FACS - ABIN2663864 : Robertson, Gip, Schaffer: Neural stem cell engineering: directed differentiation of adult and embryonic stem cells into neurons. in Frontiers in bioscience : a journal and virtual library 2007 (PubMed)
    Show all 3 references for ABIN2663864

  2. Human Monoclonal NPC1 Primary Antibody for IHC, ELISA - ABIN1724876 : Morales, Amigo, Balboa, Acuña, Castro, Molina, Miquel, Nervi, Rigotti, Zanlungo: Deficiency of Niemann-Pick C1 protein protects against diet-induced gallstone formation in mice. in Liver international : official journal of the International Association for the Study of the Liver 2010 (PubMed)
    Show all 2 references for ABIN1724876

  3. Human Monoclonal NPC1 Primary Antibody for ELISA, WB - ABIN396466 : Maetzel, Sarkar, Wang, Abi-Mosleh, Xu, Cheng, Gao, Mitalipova, Jaenisch: Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann-Pick Type C patient-specific iPS cells. in Stem cell reports 2014 (PubMed)

More Antibodies against Niemann-Pick Disease, Type C1 Interaction Partners

Zebrafish Niemann-Pick Disease, Type C1 (NPC1) interaction partners

  1. this is the first report, showing a role of NPC1 in platelet function and formation but further studies are needed to define how cholesterol storage interferes with these processes

  2. npc1 is required early for proper cell movement and cholesterol localization and later for cell survival

Rabbit Niemann-Pick Disease, Type C1 (NPC1) interaction partners

  1. Availability of assays to measure NPC1 binding to membrne proteins may further the understanding of ways in which oxysterols regulate intracellular lipid transport.

Mouse (Murine) Niemann-Pick Disease, Type C1 (NPC1) interaction partners

  1. Our data show that: i) HDAC2 (show HDAC2 Antibodies) levels and activity are increased in NPC neuronal models and in Npc1(-/-) mice; ii) inhibition of c-Abl (show ABL1 Antibodies) or c-Abl (show ABL1 Antibodies) deficiency prevents the increase of HDAC2 (show HDAC2 Antibodies) protein levels and activity in NPC neuronal models

  2. This study showed that deleting the Npc1 gene is accompanied by an increase in germ cell apoptosis and compensatory imbalances in the expression of cholesterol enzymatic and transporter factors.

  3. These results show that NPC1 is critical for ebolavirus replication and pathogenesis in animals.

  4. abnormal neuronal expression of matrix metalloproteinase-12 (show MMP12 Antibodies) may contribute to axonal degeneration in Niemann-Pick type C disease

  5. There was a transient increase in biliary cholesterol concentration in Npc1(-/-) mice.

  6. data suggest that aberrant expression of Pcdhs is a pathological process accompanied by neurodegeneration in Npc1 mutant mice

  7. This study deministrated that lack of NPC1 in either neurons or glial cells did not affect the excitability of Purkinje cells, the formation of dendrites or their excitatory synaptic activity.

  8. Hearing loss is an early consequence of Npc1 gene deletion in the mouse model of Niemann-Pick disease, type C.

  9. These data show that cholesterol homeostasis through NPC1 plays a crucial role in maintaining insulin (show INS Antibodies) action at multiple levels in adipocytes.

  10. Data suggest that axonal pathologies in Npc1 mutant spinal cord are strongly correlated with the increase of activated glial cells, which produce IL-1beta (show IL1B Antibodies) and ApoE (show APOE Antibodies), resulting in activation of p38-MAPK (show MAPK14 Antibodies) signaling pathway and enhanced phosphorylated tau protein

Human Niemann-Pick Disease, Type C1 (NPC1) interaction partners

  1. these results clearly demonstrated that the over-expression of NPC1 with a defective function in an imatinib-resistant Ph+ acute lymphoblastic leukemia cell line

  2. Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 (show NPC2 Antibodies) and Ebola virus interactions

  3. Study determined the crystal structure of the primed GP (GPcl) of Ebola virus bound to domain C of NPC1 (NPC1-C); NPC1-C utilizes two protruding loops to engage a hydrophobic cavity on head of GPcl. Upon enzymatic cleavage and NPC1-C binding, conformational change in the GPcl further affects the state of the internal fusion loop, triggering membrane fusion.

  4. Here, using live cell imaging, the authors obtained evidence that in contrast to the new model, ebolavirus enters cells through endolysosomes that contain both NPC1 and TPC2 (show TPCN2 Antibodies).

  5. These experiments support a model in which NPC1 protein functions to transfer cholesterol past a lysosomal glycocalyx.

  6. An isobaric labeling-based quantitative analysis of proteome of NPC1(I1061T) primary fibroblasts when compared with wild-type cells identified 281 differentially expressed proteins based on stringent data analysis criteria, is reported.

  7. NPC1 gene sequencing revealed that he was a compound heterozygote for the p.S954L and p.N1156S mutations.

  8. results uncover Akt (show AKT1 Antibodies) as a key regulator of NPC1 degradation and link NPC1 to cancer cell proliferation and migration.

  9. heterozygous mutations in the NPC1/2 gene might be a risk factor for Alzheimer's disease

  10. In a transgenic mouse model, human NPC1 disease was faithfully recapitulated in a NPC1 I1061T mutation knock-in model.

Niemann-Pick Disease, Type C1 (NPC1) Antigen Profile

Protein Summary

This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.

Gene names and symbols associated with NPC1

  • Niemann-Pick disease, type C1 (NPC1) antibody
  • Niemann-Pick disease, type C1 (npc1) antibody
  • Niemann Pick type C1 (Npc1) antibody
  • Niemann-Pick disease, type C1 (Npc1) antibody
  • A430089E03Rik antibody
  • C85354 antibody
  • Cdig2 antibody
  • D18Ertd139e antibody
  • D18Ertd723e antibody
  • im:7149020 antibody
  • lcsd antibody
  • nmf164 antibody
  • NPC antibody
  • spm antibody
  • wu:fb53a12 antibody
  • wu:fc29a12 antibody

Protein level used designations for NPC1

Niemann-Pick C1 protein , Niemann-Pick type C1 disease protein , Nasopharyngeal carcinoma 1 , Niemann-Pick C1 , Niemann-Pick disease, type C1 , sphingomyelinosis , Niemann-Pick C disease protein

GENE ID SPECIES
403698 Canis lupus familiaris
455338 Pan troglodytes
493693 Felis catus
553330 Danio rerio
579887 Strongylocentrotus purpuratus
100008746 Oryctolagus cuniculus
18145 Mus musculus
4864 Homo sapiens
397591 Sus scrofa
421076 Gallus gallus
266732 Rattus norvegicus
100718604 Cavia porcellus
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